42nd Annual Meeting of the Developmental Neurotoxicology Society: Held in conjunction with the 58th annual meeting of the Teratology Society, Hilton Clearwater Beach Resort Clearwater Beach, FL June 23–27, 2018
Publication date: May–June 2018Source: Neurotoxicology and Teratology, Volume 67Author(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - July 5, 2018 Category: Toxicology Source Type: research
Editorial Board
Publication date: May–June 2018Source: Neurotoxicology and Teratology, Volume 67Author(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - July 5, 2018 Category: Toxicology Source Type: research
Protective role of alpha-lipoic acid in impairments of social and stereotyped behaviors induced by early postnatal administration of thimerosal in male rat
Conclusionsthe results of this preclinical study, consistent with previous studies on mice and rats, reveals that neonatal dose-dependent exposure to Thimerosal mimicking the childhood vaccine schedule can induce abnormal social interactions and stereotyped behaviors similar to those observed in neurodevelopmental disorders such as autism, and, for the first time, revealed that these abnormalities may be ameliorated by ALA. This indicates that ALA may protect against mercurial-induced abnormal behaviors. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - July 5, 2018 Category: Toxicology Source Type: research
Exposure to mephedrone during gestation increases the risk of stillbirth and induces hippocampal neurotoxicity in mice offspring
In conclusion, the present study has shown that regular and repeated exposure to mephedrone during the gestational period increases the risk of low birth weight and stillbirth. Also, repeated use of mephedrone impairs learning and memory processes through hippocampal damage. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - July 5, 2018 Category: Toxicology Source Type: research
Positive parenting behaviors in women who spontaneously quit smoking during pregnancy: Clues to putative targets for preventive interventions
ConclusionsPutative protective characteristics in spontaneous quitters were captured in mother-child interactions at home, but not in lab-based and maternal report measures of responsiveness. Specification of these characteristics using prospective designs that oversample for spontaneous quitters is recommended to enable translation to preventive interventions. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - July 5, 2018 Category: Toxicology Source Type: research
Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae
Publication date: May–June 2018Source: Neurotoxicology and Teratology, Volume 67Author(s): Anthony N. Oliveri, Erica Ortiz, Edward D. LevinAbstractHuman exposure to organophosphate flame retardants (OPFRs) is widespread, including pregnant women and young children with whom developmental neurotoxic risk is a concern. Given similarities of OPFRs to organophosphate (OP) pesticides, research into the possible neurotoxic impacts of developmental OPFR exposure has been growing. Building upon research implicating exposure to OP pesticides in dopaminergic (DA) dysfunction, we exposed developing zebrafish to the OPFR tris(1,3-di...
Source: Neurotoxicology and Teratology - July 5, 2018 Category: Toxicology Source Type: research
Prenatal and postnatal cigarette and cannabis exposure: Effects on Secretory Immunoglobulin A in early childhood
ConclusionsPrenatal and postnatal exposure to cigarette and cannabis may be associated with hyperactivity of mucosal immunity in early childhood. Links between cigarette and cannabis exposure and health problems in early childhood may be partially explained by prenatal and postnatal exposure-related changes in mucosal immunity. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - July 5, 2018 Category: Toxicology Source Type: research
Acrylamide applied during pregnancy causes the neurotoxic effect by lowering BDNF levels in the fetal brain
ConclusionOur study indicated that acrylamide has toxic effects in the fetal brain and N-acetylcysteine prevents its toxic effect. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - July 5, 2018 Category: Toxicology Source Type: research
Developmental manganese, lead, and barren cage exposure have adverse long-term neurocognitive, behavioral and monoamine effects in Sprague-Dawley rats
Publication date: May–June 2018Source: Neurotoxicology and Teratology, Volume 67Author(s): Jenna L.N. Sprowles, Robyn M. Amos-Kroohs, Amanda A. Braun, Chiho Sugimoto, Charles V. Vorhees, Michael T. WilliamsAbstractDevelopmental stress, including low socioeconomic status (SES), can induce dysregulation of the hypothalamic-pituitary-adrenal axis and result in long-term changes in stress reactivity. Children in lower SES households experience more stress and are more likely to be exposed to environmental neurotoxins such as lead (Pb) and manganese (Mn) than children in higher SES households. Co-exposure to stress, Pb, and M...
Source: Neurotoxicology and Teratology - July 5, 2018 Category: Toxicology Source Type: research
Perfluorooctane sulfonate mediates secretion of IL-1β through PI3K/AKT NF-кB pathway in astrocytes
In this study, we showed that PFOS triggered reactive astrocytosis in time- and dose-dependent manners. The low-doses of PFOS increased the cell number and the expression of glial fibrillary acidic protein (GFAP), a well-known hallmark of reactive astrocytes, in C6 astrocyte cells. ELISA and RT-PCR analysis showed that PFOS promoted the expression and secretion of Interleukin-1 beta (IL-1β) in dose- and time-dependent manners. Furthermore, PFOS exposure could induce the phosphorylation and degradation of IκBα, and the translocation of NF-κB p65 from the cytoplasm to the nucleus in C6 glioma cell line. Thus, the NF-кB ...
Source: Neurotoxicology and Teratology - July 5, 2018 Category: Toxicology Source Type: research
Effect of repeated juvenile exposure to Δ9‑tetrahydrocannabinol on anxiety-related behavior and social interactions in adolescent rats
Publication date: Available online 21 June 2018Source: Neurotoxicology and TeratologyAuthor(s): Afzaal N. Mohammed, Navatha Alugubelly, Barbara L. Kaplan, Russell L. CarrAbstractThe gestational and adolescent periods are critically important for brain development and exposure to Δ9‑tetrahydrocannabinol (Δ9-THC) during these periods results in long term behavioral and biochemical abnormalities in laboratory animals. However, recent reports indicate a dramatic rise in oral Δ9-THC exposure in young children but the effects of this exposure scenario have not been adequately investigated. Using a model designed to mimic ch...
Source: Neurotoxicology and Teratology - July 5, 2018 Category: Toxicology Source Type: research
An examination of the association between prenatal cocaine exposure and brain activation measures of arousal and attention in young adults: An fMRI study using the Attention Network Task
This study used the theoretical model proposed by Posner and Peterson (1990), which posits three dissociable components of attention: alerting, orienting, and executive attention. Subjects completed a functional MRI (fMRI) scan while performing the Attention Network Task, a validated neuroimaging measure of the 3-network model of attention. Behavioral and fMRI data revealed no associations between PCE and task accuracy, speed of processing, or activation in key brain regions associated with each of the attention networks. The results of this study show that any subtle differences in brain function associated with PCE are n...
Source: Neurotoxicology and Teratology - July 5, 2018 Category: Toxicology Source Type: research
Prevalence and associated birth outcomes of co-use of Cannabis and tobacco cigarettes during pregnancy
Publication date: July–August 2018Source: Neurotoxicology and Teratology, Volume 68Author(s): Victoria H. Coleman-Cowger, Emmanuel A. Oga, Erica N. Peters, Katrina MarkAbstractUse of Cannabis and use of tobacco overlap, and co-use of Cannabis and tobacco has increased over the past decade among adults. The current study aims to document the prevalence and correlates of co-use of Cannabis and tobacco cigarettes among adult pregnant women utilizing secondary data from a larger study that compared and validated screeners for illicit and prescription drug use during pregnancy. Pregnant women (N = 500; 71% African America...
Source: Neurotoxicology and Teratology - July 5, 2018 Category: Toxicology Source Type: research
N-acetylcysteine inhibits Mancozeb-induced impairments to the normal development of zebrafish embryos
Publication date: July–August 2018Source: Neurotoxicology and Teratology, Volume 68Author(s): Dennis Guilherme da Costa-Silva, Luana Paganotto Leandro, Pratícia de Brum Vieira, Nelson Rodrigues de Carvalho, Andressa Rubim Lopes, Lucia Emanueli Schimith, Mauro Eugênio Medina Nunes, Renata Siqueira de Mello, Illana Kemmerich Martins, Adriano Alves de Paula, Andrés Delgado Cañedo, José Cláudio Fonseca Moreira, Thais Posser, Jeferson Luis FrancoAbstractMancozeb (MZ), a manganese/zinc-containing ethylene-bis-dithiocarbamate (EBCD) fungicide has been claimed to present low acute toxicity and short environmental persisten...
Source: Neurotoxicology and Teratology - July 5, 2018 Category: Toxicology Source Type: research
Neuroanatomical characteristics of youths with prenatal opioid and poly-drug exposure
Publication date: July–August 2018Source: Neurotoxicology and Teratology, Volume 68Author(s): Egil Nygaard, Kari Slinning, Vibeke Moe, Paulina Due-Tønnessen, Anders Fjell, Kristine B. WalhovdAbstractNeuroanatomical and cognitive differences have been documented during childhood between children with prenatal opioid- and poly-drug exposure and controls in small samples. We investigated whether these differences persisted in larger samples of youth at older ages. Quantitative MRI and cognitive data were compared between 38 youths in the risk group and 44 youths in the non-exposed group (aged 17 to 22 years) who had been...
Source: Neurotoxicology and Teratology - July 5, 2018 Category: Toxicology Source Type: research
