Potential frameworks to support evaluation of mechanistic data for developmental neurotoxicity outcomes: A symposium report

Publication date: Available online 14 February 2020Source: Neurotoxicology and TeratologyAuthor(s): Laura Carlson, Deborah A. Cory-Slechta, Frances A. Champagne, Laura Dishaw, Elaine Faustman, William Mundy, Deborah Segal, Christina Sobin, Carol Starkey, Michele Taylor, Susan L. Makris, Andrew KraftAbstractA key challenge in systematically incorporating mechanistic data into human health assessments is that, compared to studies of apical health endpoints, these data are both more abundant (mechanistic studies routinely outnumber other studies by several orders of magnitude) and more heterogeneous (e.g. different species, test system, tissue, cell type, exposure paradigm, or specific assays performed). A structured decision-making process for organizing, integrating, and weighing mechanistic DNT data for use in human health risk assessments will improve the consistency and efficiency of such evaluations. At the Developmental Neurotoxicology Society (DNTS) 2016 annual meeting, a symposium was held to address the application of existing organizing principles and frameworks for evaluation of mechanistic data relevant to interpreting neurotoxicology data. Speakers identified considerations with potential to advance the use of mechanistic DNT data in risk assessment, including considering the context of each exposure, since epigenetics, tissue type, sex, stress, nutrition and other factors can modify toxicity responses in organisms. It was also suggested that, because behavior is a...
Source: Neurotoxicology and Teratology - Category: Toxicology Source Type: research