When siblings matter: Commentary on Golub and Sobin's ‘Statistical modeling of litter as a random effect in mixed models to manage “intralitter likeness”’

Publication date: Available online 11 December 2019Source: Neurotoxicology and TeratologyAuthor(s): Lori L. DriscollAbstractResponsible data practices include acknowledging and properly dealing with data structures in which the assumption of independence of observations is violated. Golub and Sobin uncover a common statistical faux pas in neurodevelopmental research – inconsistent and inadequate handling of the clustered variability associated with the use of multiple littermates – and propose a simple mixed model solution in which litter is included as a random factor.
Source: Neurotoxicology and Teratology - Category: Toxicology Source Type: research