The control of DNA repair by the cell cycle
Nature Cell Biology 19, 1 (2017).
doi:10.1038/ncb3452
Authors: Nicole Hustedt & Daniel Durocher (Source: Nature Cell Biology)
Source: Nature Cell Biology - December 22, 2016 Category: Cytology Authors: Nicole Hustedt Daniel Durocher Tags: Review Source Type: research
LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency
Nature Cell Biology 19, 60 (2017).
doi:10.1038/ncb3453
Authors: Kaloyan M. Tsanov, Daniel S. Pearson, Zhaoting Wu, Areum Han, Robinson Triboulet, Marc T. Seligson, John T. Powers, Jihan K. Osborne, Susan Kane, Steven P. Gygi, Richard I. Gregory & George Q. Daley
Signalling and post-transcriptional gene control are both critical for the regulation of pluripotency, yet how they are integrated to influence cell identity remains poorly understood. LIN28 (also known as LIN28A), a highly conserved RNA-binding protein, has emerged as a central post-transcriptional regulator of c...
Source: Nature Cell Biology - December 18, 2016 Category: Cytology Authors: Kaloyan M. Tsanov Daniel S. Pearson Zhaoting Wu Areum Han Robinson Triboulet Marc T. Seligson John T. Powers Jihan K. Osborne Susan Kane Steven P. Gygi Richard I. Gregory George Q. Daley Tags: Letter Source Type: research
Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis
Nature Cell Biology 19, 52 (2017).
doi:10.1038/ncb3454
Authors: Martin Resnik-Docampo, Christopher L. Koehler, Rebecca I. Clark, Joseph M. Schinaman, Vivien Sauer, Daniel M. Wong, Sophia Lewis, Cecilia D’Alterio, David W. Walker & D. Leanne Jones
Ageing results in loss of tissue homeostasis across taxa. In the intestine of Drosophila melanogaster, ageing is correlated with an increase in intestinal stem cell (ISC) proliferation, a block in terminal differentiation of progenitor cells, activation of inflammatory pathways, and increased intestinal permeability. However, causal relationships between these ph...
Source: Nature Cell Biology - December 18, 2016 Category: Cytology Authors: Martin Resnik-Docampo Christopher L. Koehler Rebecca I. Clark Joseph M. Schinaman Vivien Sauer Daniel M. Wong Sophia Lewis Cecilia D ’Alterio David W. Walker D. Leanne Jones Tags: Letter Source Type: research
Nanoscale architecture of cadherin-based cell adhesions
Nature Cell Biology 19, 28 (2017).
doi:10.1038/ncb3456
Authors: Cristina Bertocchi, Yilin Wang, Andrea Ravasio, Yusuke Hara, Yao Wu, Talgat Sailov, Michelle A. Baird, Michael W. Davidson, Ronen Zaidel-Bar, Yusuke Toyama, Benoit Ladoux, Rene-Marc Mege & Pakorn Kanchanawong (Source: Nature Cell Biology)
Source: Nature Cell Biology - December 18, 2016 Category: Cytology Authors: Cristina Bertocchi Yilin Wang Andrea Ravasio Yusuke Hara Yao Wu Talgat Sailov Michelle A. Baird Michael W. Davidson Ronen Zaidel-Bar Yusuke Toyama Benoit Ladoux Rene-Marc Mege Pakorn Kanchanawong Tags: Article Source Type: research
Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining
Nature Cell Biology 19, 68 (2017).
doi:10.1038/ncb3450
Authors: Peter Ly, Levi S. Teitz, Dong H. Kim, Ofer Shoshani, Helen Skaletsky, Daniele Fachinetti, David C. Page & Don W. Cleveland
Chromosome missegregation into a micronucleus can cause complex and localized genomic rearrangements known as chromothripsis, but the underlying mechanisms remain unresolved. Here we developed an inducible Y centromere-selective inactivation strategy by exploiting a CENP-A/histone H3 chimaera to directly examine the fate of missegregated chromosomes in otherwise diploid human cells. Using this approach, we identified a temporal...
Source: Nature Cell Biology - December 4, 2016 Category: Cytology Authors: Peter Ly Levi S. Teitz Dong H. Kim Ofer Shoshani Helen Skaletsky Daniele Fachinetti David C. Page Don W. Cleveland Tags: Letter Source Type: research
A hypoxia-responsive TRAF6 –ATM–H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis
Nature Cell Biology 19, 38 (2017).
doi:10.1038/ncb3445
Authors: Abdol-Hossein Rezaeian, Chien-Feng Li, Ching-Yuan Wu, Xian Zhang, Jorge Delacerda, M. James You, Fei Han, Zhen Cai, Yun Seong Jeong, Guoxiang Jin, Liem Phan, Ping-Chieh Chou, Mong-Hong Lee, Mien-Chie Hung, Dos Sarbassov & Hui-Kuan Lin (Source: Nature Cell Biology)
Source: Nature Cell Biology - December 4, 2016 Category: Cytology Authors: Abdol-Hossein Rezaeian Chien-Feng Li Ching-Yuan Wu Xian Zhang Jorge Delacerda M. James You Fei Han Zhen Cai Yun Seong Jeong Guoxiang Jin Liem Phan Ping-Chieh Chou Mong-Hong Lee Mien-Chie Hung Dos Sarbassov Hui-Kuan Lin Tags: Article Source Type: research
Getting a grip on collective cell migration
Nature Cell Biology 18, 1265 (2016).
doi:10.1038/ncb3447
Authors: Tamal Das & Joachim P. Spatz
Many cell types in our body move in a collective manner, which requires individual cells to align their movements relative to that of their neighbours. A mechanism is now described in which cadherin-rich protrusions are extended from leading migrating cells and engulfed by follower cells to guide collective migration. (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 29, 2016 Category: Cytology Authors: Tamal Das Joachim P. Spatz Tags: News and Views Source Type: research
Erratum: Activating ATR, the devil's in the dETAA1l
Nature Cell Biology 18, 1367 (2016).
doi:10.1038/ncb3448
Author: Wojciech Niedzwiedz (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 28, 2016 Category: Cytology Authors: Wojciech Niedzwiedz Tags: Erratum Source Type: research
Remodelling germ cells by intercellular cannibalism
Nature Cell Biology 18, 1267 (2016).
doi:10.1038/ncb3449
Authors: Jennifer K. Heppert & Bob Goldstein
Work from the early 1980s reported strange lobes protruding from Caenorhabditis elegans germ cell precursors. However, the fate and potential significance of these lobes remained unexplored for decades. Now, neighbouring endodermal cells are shown to sever and digest these lobes, in an unexpected process of 'intercellular cannibalism', which could play an important part in regulating primordial germ cells. (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 28, 2016 Category: Cytology Authors: Jennifer K. Heppert Bob Goldstein Tags: News and Views Source Type: research
IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3
Nature Cell Biology 18, 1263 (2016).
doi:10.1038/ncb3440
Authors: Lucia E. Rameh & Ashley M. Mackey
Despite being one of the most studied signalling pathways, precisely how phospholipid synthesis is regulated in the phosphoinositide signalling cascade remains unclear. The scaffold protein IQGAP1 is now shown to orchestrate the assembly of a multi-enzyme complex that streamlines PtdIns(3,4,5)P3 synthesis to facilitate Akt activation in response to extracellular stimuli. (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 28, 2016 Category: Cytology Authors: Lucia E. Rameh Ashley M. Mackey Tags: News and Views Source Type: research
Andrzej K. Tarkowski 1933 –2016
Nature Cell Biology 18, 1261 (2016).
doi:10.1038/ncb3446
Author: Magdalena Zernicka-Goetz (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 28, 2016 Category: Cytology Authors: Magdalena Zernicka-Goetz Tags: Obituary Source Type: research
Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development
Nature Cell Biology 19, 17 (2017).
doi:10.1038/ncb3444
Authors: Jonathan Henninger, Buyung Santoso, Stefan Hans, Ellen Durand, Jessica Moore, Christian Mosimann, Michael Brand, David Traver & Leonard Zon (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 20, 2016 Category: Cytology Authors: Jonathan Henninger Buyung Santoso Stefan Hans Ellen Durand Jessica Moore Christian Mosimann Michael Brand David Traver Leonard Zon Tags: Article Source Type: research
Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases
Nature Cell Biology 18, 1324 (2016).
doi:10.1038/ncb3441
Authors: Suyong Choi, Andrew C. Hedman, Samar Sayedyahossein, Narendra Thapa, David B. Sacks & Richard A. Anderson (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 20, 2016 Category: Cytology Authors: Suyong Choi Andrew C. Hedman Samar Sayedyahossein Narendra Thapa David B. Sacks Richard A. Anderson Tags: Article Source Type: research
Asymmetric division coordinates collective cell migration in angiogenesis
Nature Cell Biology 18, 1292 (2016).
doi:10.1038/ncb3443
Authors: Guilherme Costa, Kyle I. Harrington, Holly E. Lovegrove, Donna J. Page, Shilpa Chakravartula, Katie Bentley & Shane P. Herbert (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 20, 2016 Category: Cytology Authors: Guilherme Costa Kyle I. Harrington Holly E. Lovegrove Donna J. Page Shilpa Chakravartula Katie Bentley Shane P. Herbert Tags: Article Source Type: research
Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation
Nature Cell Biology 18, 1281 (2016).
doi:10.1038/ncb3442
Authors: Nitya Ramkumar, Tatiana Omelchenko, Nancy F. Silva-Gagliardi, C. Jane McGlade, Jan Wijnholds & Kathryn V. Anderson (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 20, 2016 Category: Cytology Authors: Nitya Ramkumar Tatiana Omelchenko Nancy F. Silva-Gagliardi C. Jane McGlade Jan Wijnholds Kathryn V. Anderson Tags: Article Source Type: research
