Terminating the replication helicase
Nature Cell Biology 19, 410 (2017).
doi:10.1038/ncb3519
Authors: Vincent Gaggioli & Philip Zegerman
A feature of the cell cycle is that the events of one cycle must be reset before the next one begins. A study now shows that the replication machinery is removed from fully replicated DNA by a conserved ubiquitin- and CDC48 (also known as p97)-dependent pathway. This explains how eukaryotic chromosomes are returned to the unreplicated state. (Source: Nature Cell Biology)
Source: Nature Cell Biology - April 27, 2017 Category: Cytology Authors: Vincent Gaggioli Philip Zegerman Tags: News and Views Source Type: research
Science in the age of Trump
Nature Cell Biology 19, 409 (2017).
doi:10.1038/ncb3526
The steep cuts in science funding proposed in the 2018 US budget blueprint have raised alarm in scientific quarters, and signal the current administration's disregard for the significance of science and research in modern society. (Source: Nature Cell Biology)
Source: Nature Cell Biology - April 27, 2017 Category: Cytology Tags: Editorial Source Type: research
Microbial metabolites regulate host lipid metabolism through NR5A – Hedgehog signalling
Nature Cell Biology 19, 550 (2017).
doi:10.1038/ncb3515
Authors: Chih-Chun Janet Lin & Meng C. Wang
Microorganisms and their hosts share the same environment, and microbial metabolic molecules (metabolites) exert crucial effects on host physiology. Environmental factors not only shape the composition of the host’s resident microorganisms, but also modulate their metabolism. However, the exact molecular relationship among the environment, microbial metabolites and host metabolism remains largely unknown. Here, we discovered that environmental methionine tunes bacterial methyl metabolism to regulate host mi...
Source: Nature Cell Biology - April 24, 2017 Category: Cytology Authors: Chih-Chun Janet Lin Meng C. Wang Tags: Letter Source Type: research
A three-dimensional model of human lung development and disease from pluripotent stem cells
We report here the generation from hPSCs of lung bud organoids (LBOs) that contain mesoderm and pulmonary endoderm and develop into branching airway and early alveolar structures after xenotransplantation and in Matrigel 3D culture. Expression analysis and structural features indicated that the branching structures reached the second trimester of human gestation. Infection in vitro with respiratory syncytial virus, which causes small airway obstruction and bronchiolitis in infants, led to swelling, detachment and shedding of infected cells into the organoid lumens, similar to what has been observed in human lungs. Introduc...
Source: Nature Cell Biology - April 24, 2017 Category: Cytology Authors: Ya-Wen Chen Sarah Xuelian Huang Ana Luisa Rodrigues Toste de Carvalho Siu-Hong Ho Mohammad Naimul Islam Stefano Volpi Luigi D. Notarangelo Michael Ciancanelli Jean-Laurent Casanova Jahar Bhattacharya Alice F. Liang Laura M. Palermo Matteo Porotto Anne Mos Tags: Letter Source Type: research
SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis
Nature Cell Biology 19, 504 (2017).
doi:10.1038/ncb3514
Authors: Yanhui Zhang, Litao Xie, Susheel K. Gunasekar, Dan Tong, Anil Mishra, William J. Gibson, Chuansong Wang, Trevor Fidler, Brodie Marthaler, Aloysius Klingelhutz, E. Dale Abel, Isaac Samuel, Jessica K. Smith, Lei Cao & Rajan Sah (Source: Nature Cell Biology)
Source: Nature Cell Biology - April 24, 2017 Category: Cytology Authors: Yanhui Zhang Litao Xie Susheel K. Gunasekar Dan Tong Anil Mishra William J. Gibson Chuansong Wang Trevor Fidler Brodie Marthaler Aloysius Klingelhutz E. Dale Abel Isaac Samuel Jessica K. Smith Lei Cao Rajan Sah Tags: Article Source Type: research
Microtubule minus-end regulation at spindle poles by an ASPM – katanin complex
Nature Cell Biology 19, 480 (2017).
doi:10.1038/ncb3511
Authors: Kai Jiang, Lenka Rezabkova, Shasha Hua, Qingyang Liu, Guido Capitani, A. F. Maarten Altelaar, Albert J. R. Heck, Richard A. Kammerer, Michel O. Steinmetz & Anna Akhmanova (Source: Nature Cell Biology)
Source: Nature Cell Biology - April 24, 2017 Category: Cytology Authors: Kai Jiang Lenka Rezabkova Shasha Hua Qingyang Liu Guido Capitani A. F. Maarten Altelaar Albert J. R. Heck Richard A. Kammerer Michel O. Steinmetz Anna Akhmanova Tags: Article Source Type: research
Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c – SIRT2 axis
Nature Cell Biology 19, 445 (2017).
doi:10.1038/ncb3517
Authors: Young Cha, Min-Joon Han, Hyuk-Jin Cha, Janet Zoldan, Alison Burkart, Jin Hyuk Jung, Yongwoo Jang, Chun-Hyung Kim, Ho-Chang Jeong, Byung-Gyu Kim, Robert Langer, C. Ronald Kahn, Leonard Guarente & Kwang-Soo Kim (Source: Nature Cell Biology)
Source: Nature Cell Biology - April 24, 2017 Category: Cytology Authors: Young Cha Min-Joon Han Hyuk-Jin Cha Janet Zoldan Alison Burkart Jin Hyuk Jung Yongwoo Jang Chun-Hyung Kim Ho-Chang Jeong Byung-Gyu Kim Robert Langer C. Ronald Kahn Leonard Guarente Kwang-Soo Kim Tags: Article Source Type: research
Microbial metabolites regulate host lipid metabolism through NR5A –Hedgehog signalling
Nature Cell Biology 19, 550 (2017).
doi:10.1038/ncb3515
Authors: Chih-Chun Janet Lin & Meng C. Wang
Microorganisms and their hosts share the same environment, and microbial metabolic molecules (metabolites) exert crucial effects on host physiology. Environmental factors not only shape the composition of the host’s resident microorganisms, but also modulate their metabolism. However, the exact molecular relationship among the environment, microbial metabolites and host metabolism remains largely unknown. Here, we discovered that environmental methionine tunes bacterial methyl metabolism to regulate host mi...
Source: Nature Cell Biology - April 24, 2017 Category: Cytology Authors: Chih-Chun Janet Lin Meng C. Wang Tags: Letter Source Type: research
A three-dimensional model of human lung development and disease from pluripotent stem cells
We report here the generation from hPSCs of lung bud organoids (LBOs) that contain mesoderm and pulmonary endoderm and develop into branching airway and early alveolar structures after xenotransplantation and in Matrigel 3D culture. Expression analysis and structural features indicated that the branching structures reached the second trimester of human gestation. Infection in vitro with respiratory syncytial virus, which causes small airway obstruction and bronchiolitis in infants, led to swelling, detachment and shedding of infected cells into the organoid lumens, similar to what has been observed in human lungs. Introduc...
Source: Nature Cell Biology - April 24, 2017 Category: Cytology Authors: Ya-Wen Chen Sarah Xuelian Huang Ana Luisa Rodrigues Toste de Carvalho Siu-Hong Ho Mohammad Naimul Islam Stefano Volpi Luigi D. Notarangelo Michael Ciancanelli Jean-Laurent Casanova Jahar Bhattacharya Alice F. Liang Laura M. Palermo Matteo Porotto Anne Mos Tags: Letter Source Type: research
SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis
Nature Cell Biology 19, 504 (2017).
doi:10.1038/ncb3514
Authors: Yanhui Zhang, Litao Xie, Susheel K. Gunasekar, Dan Tong, Anil Mishra, William J. Gibson, Chuansong Wang, Trevor Fidler, Brodie Marthaler, Aloysius Klingelhutz, E. Dale Abel, Isaac Samuel, Jessica K. Smith, Lei Cao & Rajan Sah (Source: Nature Cell Biology)
Source: Nature Cell Biology - April 24, 2017 Category: Cytology Authors: Yanhui Zhang Litao Xie Susheel K. Gunasekar Dan Tong Anil Mishra William J. Gibson Chuansong Wang Trevor Fidler Brodie Marthaler Aloysius Klingelhutz E. Dale Abel Isaac Samuel Jessica K. Smith Lei Cao Rajan Sah Tags: Article Source Type: research
Microtubule minus-end regulation at spindle poles by an ASPM –katanin complex
Nature Cell Biology 19, 480 (2017).
doi:10.1038/ncb3511
Authors: Kai Jiang, Lenka Rezabkova, Shasha Hua, Qingyang Liu, Guido Capitani, A. F. Maarten Altelaar, Albert J. R. Heck, Richard A. Kammerer, Michel O. Steinmetz & Anna Akhmanova (Source: Nature Cell Biology)
Source: Nature Cell Biology - April 24, 2017 Category: Cytology Authors: Kai Jiang Lenka Rezabkova Shasha Hua Qingyang Liu Guido Capitani A. F. Maarten Altelaar Albert J. R. Heck Richard A. Kammerer Michel O. Steinmetz Anna Akhmanova Tags: Article Source Type: research
Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c –SIRT2 axis
Nature Cell Biology 19, 445 (2017).
doi:10.1038/ncb3517
Authors: Young Cha, Min-Joon Han, Hyuk-Jin Cha, Janet Zoldan, Alison Burkart, Jin Hyuk Jung, Yongwoo Jang, Chun-Hyung Kim, Ho-Chang Jeong, Byung-Gyu Kim, Robert Langer, C. Ronald Kahn, Leonard Guarente & Kwang-Soo Kim (Source: Nature Cell Biology)
Source: Nature Cell Biology - April 24, 2017 Category: Cytology Authors: Young Cha Min-Joon Han Hyuk-Jin Cha Janet Zoldan Alison Burkart Jin Hyuk Jung Yongwoo Jang Chun-Hyung Kim Ho-Chang Jeong Byung-Gyu Kim Robert Langer C. Ronald Kahn Leonard Guarente Kwang-Soo Kim Tags: Article Source Type: research
When cancer needs what's non-essential
Nature Cell Biology 19, 418 (2017).
doi:10.1038/ncb3523
Authors: Mark R. Sullivan & Matthew G. Vander Heiden
The non-essential amino acids serine and glycine are critical for proliferative metabolism. A study in Nature now finds that dietary serine and glycine deprivation inhibits growth of some tumours. Whether this dietary intervention is effective depends on both the oncogenic context and tumour tissue of origin. (Source: Nature Cell Biology)
Source: Nature Cell Biology - April 19, 2017 Category: Cytology Authors: Mark R. Sullivan Matthew G. Vander Heiden Tags: News and Views Source Type: research
High-resolution myogenic lineage mapping by single-cell mass cytometry
Nature Cell Biology 19, 558 (2017).
doi:10.1038/ncb3507
Authors: Ermelinda Porpiglia, Nikolay Samusik, Andrew Tri Van Ho, Benjamin D. Cosgrove, Thach Mai, Kara L. Davis, Astraea Jager, Garry P. Nolan, Sean C. Bendall, Wendy J. Fantl & Helen M. Blau (Source: Nature Cell Biology)
Source: Nature Cell Biology - April 17, 2017 Category: Cytology Authors: Ermelinda Porpiglia Nikolay Samusik Andrew Tri Van Ho Benjamin D. Cosgrove Thach Mai Kara L. Davis Astraea Jager Garry P. Nolan Sean C. Bendall Wendy J. Fantl Helen M. Blau Tags: Resource Source Type: research
