Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive
Nature Cell Biology 19, 164 (2017). doi:10.1038/ncb3471 Authors: Nai Yang Fu, Anne C. Rios, Bhupinder Pal, Charity W. Law, Paul Jamieson, Ruijie Liu, François Vaillant, Felicity Jackling, Kevin He Liu, Gordon K. Smyth, Geoffrey J. Lindeman, Matthew E. Ritchie & Jane E. Visvader (Source: Nature Cell Biology)
Source: Nature Cell Biology - February 12, 2017 Category: Cytology Authors: Nai Yang Fu Anne C. Rios Bhupinder Pal Charity W. Law Paul Jamieson Ruijie Liu Fran çois Vaillant Felicity Jackling Kevin He Liu Gordon K. Smyth Geoffrey J. Lindeman Matthew  E. Ritchie Jane E. Visvader Tags: Article Source Type: research

Insulin-like signalling to the maternal germline controls progeny response to osmotic stress
We report that the nematode Caenorhabditis elegans can protect itself from osmotic stress by entering a state of arrested development and can protect its progeny from osmotic stress by increasing the expression of the glycerol biosynthetic enzyme GPDH-2 in progeny. Both of these protective mechanisms are regulated by insulin-like signalling: insulin-like signalling to the intestine regulates developmental arrest, while insulin-like signalling to the maternal germline regulates glycerol metabolism in progeny. Thus, there is a heritable link between insulin-like signalling to the maternal germline and progeny metabolism and ...
Source: Nature Cell Biology - February 5, 2017 Category: Cytology Authors: Nicholas O. Burton Tokiko Furuta Amy K. Webster Rebecca E. W. Kaplan L. Ryan Baugh Swathi Arur H. Robert Horvitz Tags: Letter Source Type: research

Corrigendum: Mitotic internalization of planar cell polarity proteins preserves tissue polarity
Nature Cell Biology 19, 143 (2017). doi:10.1038/ncb3469 Author: Danelle Devenport, Daniel Oristian, Evan Heller & Elaine Fuchs (Source: Nature Cell Biology)
Source: Nature Cell Biology - January 30, 2017 Category: Cytology Authors: Danelle Devenport Daniel Oristian Evan Heller Elaine Fuchs Tags: Corrigendum Source Type: research

Corrigendum: Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development
Nature Cell Biology 19, 142 (2017). doi:10.1038/ncb3462 Author: Jonathan Henninger, Buyung Santoso, Stefan Hans, Ellen Durand, Jessica Moore, Christian Mosimann, Michael Brand, David Traver & Leonard Zon (Source: Nature Cell Biology)
Source: Nature Cell Biology - January 30, 2017 Category: Cytology Authors: Jonathan Henninger Buyung Santoso Stefan Hans Ellen Durand Jessica Moore Christian Mosimann Michael Brand David Traver Leonard Zon Tags: Corrigendum Source Type: research

Lnc-ing ROR1 –HER3 and Hippo signalling in metastasis
Nature Cell Biology 19, 81 (2017). doi:10.1038/ncb3467 Authors: Wei Zhuo & Yibin Kang Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1–HER3 and Hippo–YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis. (Source: Nature Cell Biology)
Source: Nature Cell Biology - January 30, 2017 Category: Cytology Authors: Wei Zhuo Yibin Kang Tags: News and Views Source Type: research

CPEB4 links the clock and the UPR to protect the liver
Nature Cell Biology 19, 79 (2017). doi:10.1038/ncb3460 Authors: Paul C. Moore & Scott A. Oakes Under misfolded protein stress, the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis, or commits the cell to apoptosis. A study now uncovers how the UPR is governed by the circadian clock to adjust ER protein-folding capacity to metabolic demand and protect against liver damage. (Source: Nature Cell Biology)
Source: Nature Cell Biology - January 30, 2017 Category: Cytology Authors: Paul C. Moore Scott A. Oakes Tags: News and Views Source Type: research

Growing, splitting and stacking myosin II filaments
Nature Cell Biology 19, 77 (2017). doi:10.1038/ncb3468 Author: Margaret A. Titus Spectacular images of the process of myosin II filament formation and organization in migrating cells are unveiled by super-resolution imaging. A combination of short- and long-range interactions with actin filaments is seen to play a critical role in filament partitioning and alignment into contractile actin arcs and stress fibres. (Source: Nature Cell Biology)
Source: Nature Cell Biology - January 30, 2017 Category: Cytology Authors: Margaret A. Titus Tags: News and Views Source Type: research

Long-range self-organization of cytoskeletal myosin II filament stacks
Nature Cell Biology 19, 133 (2017). doi:10.1038/ncb3466 Authors: Shiqiong Hu, Kinjal Dasbiswas, Zhenhuan Guo, Yee-Han Tee, Visalatchi Thiagarajan, Pascal Hersen, Teng-Leong Chew, Samuel A. Safran, Ronen Zaidel-Bar & Alexander D. Bershadsky Although myosin II filaments are known to exist in non-muscle cells, their dynamics and organization are incompletely understood. Here, we combined structured illumination microscopy with pharmacological and genetic perturbations, to study the process of actomyosin cytoskeleton self-organization into arcs and stress fibres. A striking feature of the myosin II filament organi...
Source: Nature Cell Biology - January 22, 2017 Category: Cytology Authors: Shiqiong Hu Kinjal Dasbiswas Zhenhuan Guo Yee-Han Tee Visalatchi Thiagarajan Pascal Hersen Teng-Leong Chew Samuel A. Safran Ronen Zaidel-Bar Alexander D. Bershadsky Tags: Letter Source Type: research

A ROR1 –HER3–lncRNA signalling axis modulates the Hippo–YAP pathway to regulate bone metastasis
Nature Cell Biology 19, 106 (2017). doi:10.1038/ncb3464 Authors: Chunlai Li, Shouyu Wang, Zhen Xing, Aifu Lin, Ke Liang, Jian Song, Qingsong Hu, Jun Yao, Zhongyuan Chen, Peter K. Park, David H. Hawke, Jianwei Zhou, Yan Zhou, Shuxing Zhang, Han Liang, Mien-Chie Hung, Gary E. Gallick, Leng Han, Chunru Lin & Liuqing Yang (Source: Nature Cell Biology)
Source: Nature Cell Biology - January 22, 2017 Category: Cytology Authors: Chunlai Li Shouyu Wang Zhen Xing Aifu Lin Ke Liang Jian Song Qingsong Hu Jun Yao Zhongyuan Chen Peter  K. Park David  H. Hawke Jianwei Zhou Yan Zhou Shuxing Zhang Han Liang Mien-Chie Hung Gary  E. Gallick Leng Han Chunru Lin Liuqing Yang Tags: Article Source Type: research

Actin dynamics and competition for myosin monomer govern the sequential amplification of myosin filaments
Nature Cell Biology 19, 85 (2017). doi:10.1038/ncb3463 Authors: Jordan R. Beach, Kyle S. Bruun, Lin Shao, Dong Li, Zac Swider, Kirsten Remmert, Yingfan Zhang, Mary A. Conti, Robert S. Adelstein, Nasser M. Rusan, Eric Betzig & John A. Hammer (Source: Nature Cell Biology)
Source: Nature Cell Biology - January 22, 2017 Category: Cytology Authors: Jordan R. Beach Kyle S. Bruun Lin Shao Dong Li Zac Swider Kirsten Remmert Yingfan Zhang Mary A. Conti Robert S. Adelstein Nasser M. Rusan Eric Betzig John A. Hammer Tags: Article Source Type: research

Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress
Nature Cell Biology 19, 94 (2017). doi:10.1038/ncb3461 Authors: Carlos Maillo, Judit Martín, David Sebastián, Maribel Hernández-Alvarez, Mar García-Rocha, Oscar Reina, Antonio Zorzano, Mercedes Fernandez & Raúl Méndez (Source: Nature Cell Biology)
Source: Nature Cell Biology - January 15, 2017 Category: Cytology Authors: Carlos Maillo Judit Mart ín David Sebasti án Maribel Hern ández-Alvarez Mar Garc ía-Rocha Oscar Reina Antonio Zorzano Mercedes Fernandez Ra úl Méndez Tags: Article Source Type: research

Retraction: G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/ β-catenin pathway
Nature Cell Biology 19, 76 (2017). doi:10.1038/ncb3455 Author: Shih-Ting Cha, Ching-Ting Tan, Cheng-Chi Chang, Chia-Yu Chu, Wei-Jiunn Lee, Been-Zen Lin, Ming-Tsan Lin & Min-Liang Kuo (Source: Nature Cell Biology)
Source: Nature Cell Biology - December 22, 2016 Category: Cytology Authors: Shih-Ting Cha Ching-Ting Tan Cheng-Chi Chang Chia-Yu Chu Wei-Jiunn Lee Been-Zen Lin Ming-Tsan Lin Min-Liang Kuo Tags: Retraction Source Type: research

Resolving the cadherin –F-actin connection
Nature Cell Biology 19, 14 (2017). doi:10.1038/ncb3457 Authors: Mitchell K. L. Han & Johan de Rooij Cadherin adhesion complexes have recently emerged as sensors of tissue tension that regulate key developmental processes. Super-resolution microscopy experiments now unravel the spatial organization of the interface between cadherins and the actin cytoskeleton and reveal how vinculin, a central component in cadherin mechanotransduction, is regulated by mechanical and biochemical signals. (Source: Nature Cell Biology)
Source: Nature Cell Biology - December 22, 2016 Category: Cytology Authors: Mitchell K. L. Han Johan de Rooij Tags: News and Views Source Type: research

Y chromothripsis?
Nature Cell Biology 19, 12 (2017). doi:10.1038/ncb3458 Author: Emily M. Hatch Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process, including a role for non-homologous end joining. (Source: Nature Cell Biology)
Source: Nature Cell Biology - December 22, 2016 Category: Cytology Authors: Emily M. Hatch Tags: News and Views Source Type: research

Haematopoietic stem cells show their true colours
Nature Cell Biology 19, 10 (2017). doi:10.1038/ncb3459 Authors: Trista E. North & Wolfram Goessling Delineating the behaviour of haematopoietic stem cells (HSCs) in vivo has thus far proven challenging. Two studies in zebrafish and mouse models now track HSCs in vivo using fate mapping with multicolour approaches to provide further insights into clonal events that regulate blood development, HSC function and differentiation during homeostasis and stress conditions. (Source: Nature Cell Biology)
Source: Nature Cell Biology - December 22, 2016 Category: Cytology Authors: Trista E. North Wolfram Goessling Tags: News and Views Source Type: research