IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3

Nature Cell Biology 18, 1263 (2016). doi:10.1038/ncb3440 Authors: Lucia E. Rameh & Ashley M. Mackey Despite being one of the most studied signalling pathways, precisely how phospholipid synthesis is regulated in the phosphoinositide signalling cascade remains unclear. The scaffold protein IQGAP1 is now shown to orchestrate the assembly of a multi-enzyme complex that streamlines PtdIns(3,4,5)P3 synthesis to facilitate Akt activation in response to extracellular stimuli.

http://feeds.nature.com/~r/ncb/rss/current/~3/fxIB2NlJt-4/ncb3440

Source: Nature Cell Biology - November 28, 2016 Category: Cytology Authors: Lucia E. Rameh Ashley M. Mackey Tags: News and Views Source Type: research

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