Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells
Nature Cell Biology 18, 1311 (2016).
doi:10.1038/ncb3438
Authors: Arnold Hayer, Lin Shao, Mingyu Chung, Lydia-Marie Joubert, Hee Won Yang, Feng-Chiao Tsai, Anjali Bisaria, Eric Betzig & Tobias Meyer (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 13, 2016 Category: Cytology Authors: Arnold Hayer Lin Shao Mingyu Chung Lydia-Marie Joubert Hee Won Yang Feng-Chiao Tsai Anjali Bisaria Eric Betzig Tobias Meyer Tags: Article Source Type: research
Developmentally programmed germ cell remodelling by endodermal cell cannibalism
Nature Cell Biology 18, 1302 (2016).
doi:10.1038/ncb3439
Authors: Yusuff Abdu, Chelsea Maniscalco, John M. Heddleston, Teng-Leong Chew & Jeremy Nance (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 13, 2016 Category: Cytology Authors: Yusuff Abdu Chelsea Maniscalco John M. Heddleston Teng-Leong Chew Jeremy Nance Tags: Article Source Type: research
Tissue mechanics promote IDH1-dependent HIF1 α–tenascin C feedback to regulate glioblastoma aggression
Nature Cell Biology 18, 1336 (2016).
doi:10.1038/ncb3429
Authors: Yekaterina A. Miroshnikova, Janna K. Mouw, J. Matthew Barnes, Michael W. Pickup, Johnathan N. Lakins, Youngmi Kim, Khadjia Lobo, Anders I. Persson, Gerald F. Reis, Tracy R. McKnight, Eric C. Holland, Joanna J. Phillips & Valerie M. Weaver (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 6, 2016 Category: Cytology Authors: Yekaterina A. Miroshnikova Janna K. Mouw J. Matthew Barnes Michael W. Pickup Johnathan N. Lakins Youngmi Kim Khadjia Lobo Anders I. Persson Gerald F. Reis Tracy R. McKnight Eric C. Holland Joanna J. Phillips Valerie M. Weaver Tags: Article Source Type: research
Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors
Nature Cell Biology 18, 1269 (2016).
doi:10.1038/ncb3437
Authors: Michael M. Kaminski, Jelena Tosic, Catena Kresbach, Hannes Engel, Jonas Klockenbusch, Anna-Lena Müller, Roman Pichler, Florian Grahammer, Oliver Kretz, Tobias B. Huber, Gerd Walz, Sebastian J. Arnold & Soeren S. Lienkamp (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 6, 2016 Category: Cytology Authors: Michael M. Kaminski Jelena Tosic Catena Kresbach Hannes Engel Jonas Klockenbusch Anna-Lena M üller Roman Pichler Florian Grahammer Oliver Kretz Tobias B. Huber Gerd Walz Sebastian J. Arnold Soeren S. Lienkamp Tags: Article Source Type: research
Erratum: Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow
Nature Cell Biology 18, 1260 (2016).
doi:10.1038/ncb3433
Author: Rachelle W. Johnson, Elizabeth C. Finger, Monica M. Olcina, Marta Vilalta, Todd Aguilera, Yu Miao, Alyssa R. Merkel, Joshua R. Johnson, Julie A. Sterling, Joy Y. Wu & Amato J. Giaccia (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 26, 2016 Category: Cytology Authors: Rachelle W. Johnson Elizabeth C. Finger Monica M. Olcina Marta Vilalta Todd Aguilera Yu Miao Alyssa R. Merkel Joshua R. Johnson Julie A. Sterling Joy Y. Wu Amato J. Giaccia Tags: Erratum Source Type: research
A new bookmark of the mitotic genome in embryonic stem cells
Nature Cell Biology 18, 1124 (2016).
doi:10.1038/ncb3432
Authors: Chris C.-S. Hsiung & Gerd A. Blobel
Embryonic stem cells maintain pluripotency through countless mitoses. A recent report shows that the transcription factor Esrrb remains bound to chromatin during mitosis, including at regulatory regions that support pluripotency. Mitotic chromatin occupancy by Esrrb might stabilize the defining transcriptional programmes of embryonic stem cells through cell division. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 26, 2016 Category: Cytology Authors: Chris C.-S. Hsiung Gerd A. Blobel Tags: News and Views Source Type: research
Targeting mutant p53 through the mevalonate pathway
Nature Cell Biology 18, 1122 (2016).
doi:10.1038/ncb3435
Authors: William Freed-Pastor & Carol Prives
It is well established that mutant forms of the p53 tumour suppressor acquire pro-oncogenic activities. Inhibition of the mevalonate pathway is now shown to promote degradation of select oncogenic mutant p53 proteins, indicating that destabilization of mutant p53 could be a promising therapeutic strategy. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 26, 2016 Category: Cytology Authors: William Freed-Pastor Carol Prives Tags: News and Views Source Type: research
Activating ATR, the devil's in the dETAA1l
Nature Cell Biology 18, 1120 (2016).
doi:10.1038/ncb3431
Author: Wojciech Niedzwiedz
Two studies now show that Ewing's tumour-associated antigen 1 (ETAA1) is recruited to sites of DNA replication stress through its interaction with replication protein A, where it stimulates the ATR kinase to promote efficient genome duplication. These findings provide exciting insight into the already very complex regulatory mechanism of the ATR activation cascade. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 26, 2016 Category: Cytology Authors: Wojciech Niedzwiedz Tags: News and Views Source Type: research
On keeping the right ER size
Nature Cell Biology 18, 1118 (2016).
doi:10.1038/ncb3430
Author: Sebastian Schuck
The endoplasmic reticulum (ER) is the largest membrane-bound organelle in cells, and its size needs to be carefully controlled. Downsizing the ER by autophagy is now shown to involve Sec62, a protein that also helps to build up the organelle. This link suggests a molecular switch for ER size control. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 26, 2016 Category: Cytology Authors: Sebastian Schuck Tags: News and Views Source Type: research
DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway
Nature Cell Biology 18, 1233 (2016).
doi:10.1038/ncb3427
Authors: Alejandro Parrales, Atul Ranjan, Swathi V. Iyer, Subhash Padhye, Scott J. Weir, Anuradha Roy & Tomoo Iwakuma (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 23, 2016 Category: Cytology Authors: Alejandro Parrales Atul Ranjan Swathi V. Iyer Subhash Padhye Scott J. Weir Anuradha Roy Tomoo Iwakuma Tags: Article Source Type: research
Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer
Nature Cell Biology 18, 1221 (2016).
doi:10.1038/ncb3425
Authors: Ting Ni, Xiao-Yan Li, Na Lu, Teng An, Zhi-Ping Liu, Rong Fu, Wen-Cong Lv, Yi-Wei Zhang, Xiao-Jun Xu, R. Grant Rowe, Yong-Shun Lin, Amanda Scherer, Tamar Feinberg, Xiao-Qi Zheng, Bao-An Chen, X. Shirley Liu, Qing-Long Guo, Zhao-Qiu Wu & Stephen J. Weiss (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 16, 2016 Category: Cytology Authors: Ting Ni Xiao-Yan Li Na Lu Teng An Zhi-Ping Liu Rong Fu Wen-Cong Lv Yi-Wei Zhang Xiao-Jun Xu R. Grant Rowe Yong-Shun Lin Amanda Scherer Tamar Feinberg Xiao-Qi Zheng Bao-An Chen X. Shirley Liu Qing-Long Guo Zhao-Qiu Wu Stephen J. Weiss Tags: Article Source Type: research
Amnioserosa cell constriction but not epidermal actin cable tension autonomously drives dorsal closure
Nature Cell Biology 18, 1161 (2016).
doi:10.1038/ncb3420
Authors: Laurynas Pasakarnis, Erich Frei, Emmanuel Caussinus, Markus Affolter & Damian Brunner (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 16, 2016 Category: Cytology Authors: Laurynas Pasakarnis Erich Frei Emmanuel Caussinus Markus Affolter Damian Brunner Tags: Article Source Type: research
The actin cable is dispensable in directing dorsal closure dynamics but neutralizes mechanical stress to prevent scarring in the Drosophila embryo
Nature Cell Biology 18, 1149 (2016).
doi:10.1038/ncb3421
Authors: Antoine Ducuing & Stéphane Vincent (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 16, 2016 Category: Cytology Authors: Antoine Ducuing St éphane Vincent Tags: Article Source Type: research
Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a
Nature Cell Biology 18, 1127 (2016).
doi:10.1038/ncb3424
Authors: Alexandros Strikoudis, Charalampos Lazaris, Thomas Trimarchi, Antonio L. Galvao Neto, Yan Yang, Panagiotis Ntziachristos, Scott Rothbart, Shannon Buckley, Igor Dolgalev, Matthias Stadtfeld, Brian D. Strahl, Brian D. Dynlacht, Aristotelis Tsirigos & Iannis Aifantis (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 16, 2016 Category: Cytology Authors: Alexandros Strikoudis Charalampos Lazaris Thomas Trimarchi Antonio L. Galvao Neto Yan Yang Panagiotis Ntziachristos Scott Rothbart Shannon Buckley Igor Dolgalev Matthias Stadtfeld Brian D. Strahl Brian D. Dynlacht Aristotelis Tsirigos Iannis Aifantis Tags: Article Source Type: research
Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice
Nature Cell Biology 18, 1208 (2016).
doi:10.1038/ncb3417
Authors: Marcello Stanzione, Marek Baumann, Frantzeskos Papanikos, Ihsan Dereli, Julian Lange, Angelique Ramlal, Daniel Tränkner, Hiroki Shibuya, Bernard de Massy, Yoshinori Watanabe, Maria Jasin, Scott Keeney & Attila Tóth (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 9, 2016 Category: Cytology Authors: Marcello Stanzione Marek Baumann Frantzeskos Papanikos Ihsan Dereli Julian Lange Angelique Ramlal Daniel Tr änkner Hiroki Shibuya Bernard de Massy Yoshinori Watanabe Maria Jasin Scott Keeney Attila T óth Tags: Article Source Type: research
