Preserving protein function through reversible aggregation
Nature Cell Biology 19, 1142 (2017).
doi:10.1038/ncb3620
Author: Jörg Höhfeld
It is generally accepted that protein function depends on a defined 3D structure, with unfolding and aggregation dealing a final blow to functionality. A study now shows that the regulated exposure of an unstructured region in yeast pyruvate kinase triggers reversible aggregation to preserve protein function under stress. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 29, 2017 Category: Cytology Authors: J ö rg H ö hfeld Tags: News and Views Source Type: research
A long and winding sTORy
Nature Cell Biology 19, 1131 (2017).
doi:10.1038/ncb3624 (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 28, 2017 Category: Cytology Tags: Editorial Source Type: research
Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor
Nature Cell Biology 19, 1226 (2017).
doi:10.1038/ncb3616
Authors: Xiaofeng Wu, Li-shu Zhang, Jason Toombs, Yi-Chun Kuo, John Tyler Piazza, Rubina Tuladhar, Quinn Barrett, Chih-wei Fan, Xuewu Zhang, Loren D. Walensky, Marcel Kool, Steven Y. Cheng, Rolf Brekken, Joseph T. Opferman, Douglas R. Green, Tudor Moldoveanu & Lawrence Lum (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 25, 2017 Category: Cytology Authors: Xiaofeng Wu Li-shu Zhang Jason Toombs Yi-Chun Kuo John Tyler Piazza Rubina Tuladhar Quinn Barrett Chih-wei Fan Xuewu Zhang Loren D. Walensky Marcel Kool Steven Y. Cheng Rolf Brekken Joseph T. Opferman Douglas R. Green Tudor Moldoveanu Lawrence Lum Tags: Article Source Type: research
Insulin fine-tunes self-renewal pathways governing naive pluripotency and extra-embryonic endoderm
Nature Cell Biology 19, 1164 (2017).
doi:10.1038/ncb3617
Authors: Kathryn G. V. Anderson, William B. Hamilton, Fabian V. Roske, Ajuna Azad, Teresa E. Knudsen, Maurice A. Canham, Lesley M. Forrester & Joshua M. Brickman (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 25, 2017 Category: Cytology Authors: Kathryn G. V. Anderson William B. Hamilton Fabian V. Roske Ajuna Azad Teresa E. Knudsen Maurice A. Canham Lesley M. Forrester Joshua M. Brickman Tags: Article Source Type: research
Cell plasticity in epithelial homeostasis and tumorigenesis
Nature Cell Biology 19, 1133 (2017).
doi:10.1038/ncb3611
Authors: Julia Varga & Florian R. Greten (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 25, 2017 Category: Cytology Authors: Julia Varga Florian R. Greten Tags: Review Source Type: research
miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS
Nature Cell Biology 19, 1286 (2017).
doi:10.1038/ncb3615
Authors: Min-Zu Wu, Wei-Chung Cheng, Su-Feng Chen, Shin Nieh, Carolyn O’Connor, Chia-Lin Liu, Wen-Wei Tsai, Cheng-Jang Wu, Lorena Martin, Yaoh-Shiang Lin, Kou-Juey Wu, Li-Fan Lu & Juan Carlos Izpisua Belmonte (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 18, 2017 Category: Cytology Authors: Min-Zu Wu Wei-Chung Cheng Su-Feng Chen Shin Nieh Carolyn O ’ Connor Chia-Lin Liu Wen-Wei Tsai Cheng-Jang Wu Lorena Martin Yaoh-Shiang Lin Kou-Juey Wu Li-Fan Lu Juan Carlos Izpisua Belmonte Tags: Article Source Type: research
p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection
Nature Cell Biology 19, 1248 (2017).
doi:10.1038/ncb3614
Authors: Manoj B. Menon, Julia Gropengießer, Jessica Fischer, Lena Novikova, Anne Deuretzbacher, Juri Lafera, Hanna Schimmeck, Nicole Czymmeck, Natalia Ronkina, Alexey Kotlyarov, Martin Aepfelbacher, Matthias Gaestel & Klaus Ruckdeschel (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 18, 2017 Category: Cytology Authors: Manoj B. Menon Julia Gropengie ß er Jessica Fischer Lena Novikova Anne Deuretzbacher Juri Lafera Hanna Schimmeck Nicole Czymmeck Natalia Ronkina Alexey Kotlyarov Martin Aepfelbacher Matthias Gaestel Klaus Ruckdeschel Tags: Article Source Type: research
MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death
Nature Cell Biology 19, 1237 (2017).
doi:10.1038/ncb3608
Authors: Yves Dondelinger, Tom Delanghe, Diego Rojas-Rivera, Dario Priem, Tinneke Delvaeye, Inge Bruggeman, Franky Van Herreweghe, Peter Vandenabeele & Mathieu J. M. Bertrand (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 18, 2017 Category: Cytology Authors: Yves Dondelinger Tom Delanghe Diego Rojas-Rivera Dario Priem Tinneke Delvaeye Inge Bruggeman Franky Van Herreweghe Peter Vandenabeele Mathieu J. M. Bertrand Tags: Article Source Type: research
Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny
Nature Cell Biology 19, 1153 (2017).
doi:10.1038/ncb3607
Authors: Miguel Ganuza, Trent Hall, David Finkelstein, Ashley Chabot, Guolian Kang & Shannon McKinney-Freeman (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 18, 2017 Category: Cytology Authors: Miguel Ganuza Trent Hall David Finkelstein Ashley Chabot Guolian Kang Shannon McKinney-Freeman Tags: Article Source Type: research
Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1
Nature Cell Biology 19, 1274 (2017).
doi:10.1038/ncb3613
Authors: Xueqian Zhuang, Hao Zhang, Xiaoyan Li, Xiaoxun Li, Min Cong, Fangli Peng, Jingyi Yu, Xue Zhang, Qifeng Yang & Guohong Hu (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 11, 2017 Category: Cytology Authors: Xueqian Zhuang Hao Zhang Xiaoyan Li Xiaoxun Li Min Cong Fangli Peng Jingyi Yu Xue Zhang Qifeng Yang Guohong Hu Tags: Article Source Type: research
A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1
Nature Cell Biology 19, 1260 (2017).
doi:10.1038/ncb3609
Authors: Ji-Hyung Lee, Su Myung Jung, Kyung-Min Yang, Eunjin Bae, Sung Gwe Ahn, Jin Seok Park, Dongyeob Seo, Minbeom Kim, Jihoon Ha, Jaewon Lee, Jun-Hyeong Kim, Jun Hwan Kim, Akira Ooshima, Jinah Park, Donghyuk Shin, Youn Sook Lee, Sangho Lee, Geert van Loo, Joon Jeong, Seong-Jin Kim & Seok Hee Park (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 11, 2017 Category: Cytology Authors: Ji-Hyung Lee Su Myung Jung Kyung-Min Yang Eunjin Bae Sung Gwe Ahn Jin Seok Park Dongyeob Seo Minbeom Kim Jihoon Ha Jaewon Lee Jun-Hyeong Kim Jun Hwan Kim Akira Ooshima Jinah Park Donghyuk Shin Youn Sook Lee Sangho Lee Geert van Loo Joon Jeong Seong-Jin Ki Tags: Article Source Type: research
Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling
Nature Cell Biology 19, 1214 (2017).
doi:10.1038/ncb3610
Authors: Kerrie E. McNally, Rebecca Faulkner, Florian Steinberg, Matthew Gallon, Rajesh Ghai, David Pim, Paul Langton, Neil Pearson, Chris M. Danson, Heike Nägele, Lindsey L. Morris, Amika Singla, Brittany L. Overlee, Kate J. Heesom, Richard Sessions, Lawrence Banks, Brett M. Collins, Imre Berger, Daniel D. Billadeau, Ezra Burstein & Peter J. Cullen (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 11, 2017 Category: Cytology Authors: Kerrie E. McNally Rebecca Faulkner Florian Steinberg Matthew Gallon Rajesh Ghai David Pim Paul Langton Neil Pearson Chris M. Danson Heike N ä gele Lindsey L. Morris Amika Singla Brittany L. Overlee Kate J. Heesom Richard Sessions Lawrence Banks Brett Tags: Article Source Type: research
Myofibril contraction and crosslinking drive nuclear movement to the periphery of skeletal muscle
Nature Cell Biology 19, 1189 (2017).
doi:10.1038/ncb3605
Authors: William Roman, João P. Martins, Filomena A. Carvalho, Raphael Voituriez, Jasmine V. G. Abella, Nuno C. Santos, Bruno Cadot, Michael Way & Edgar R. Gomes (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 11, 2017 Category: Cytology Authors: William Roman Jo ã o P. Martins Filomena A. Carvalho Raphael Voituriez Jasmine V. G. Abella Nuno C. Santos Bruno Cadot Michael Way Edgar R. Gomes Tags: Article Source Type: research
A caspase-independent way to kill cancer cells
Nature Cell Biology 19, 1014 (2017).
doi:10.1038/ncb3604
Authors: Brent E. Fitzwalter & Andrew Thorburn
Cancer treatments often focus on killing tumour cells through apoptosis, which is thought to typically require mitochondrial outer membrane permeabilization (MOMP) and subsequent caspase activation. A study now shows that MOMP can trigger TNF-dependent, but caspase-independent cell death, suggesting a different approach to improve cancer therapy. (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 31, 2017 Category: Cytology Authors: Brent E. Fitzwalter Andrew Thorburn Tags: News and Views Source Type: research
A fruitful liaison of ZSCAN10 and ROS on the road to rejuvenation
Nature Cell Biology 19, 1012 (2017).
doi:10.1038/ncb3602
Authors: Clea Bárcena & Carlos López-Otín
Induced pluripotent stem cells derived from aged donors (A-iPSCs) usually show genomic instability that affects their utility and raises concerns about their safety. Now, a study highlights the importance of ZSCAN10-dependent recovery of glutathione–ROS homeostasis in counteracting the genomic defects in A-iPSCs. (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 31, 2017 Category: Cytology Authors: Clea B á rcena Carlos L ó pez-Ot í n Tags: News and Views Source Type: research
