Addendum: A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression
Nature Cell Biology 19, 1443 (2017).
doi:10.1038/ncb3647
Author: Simon Grelet, Laura A. Link, Breege Howley, Clémence Obellianne, Viswanathan Palanisamy, Vamsi K. Gangaraju, J. Alan Diehl & Philip H. Howe (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 29, 2017 Category: Cytology Authors: Simon Grelet Laura A. Link Breege Howley Cl é mence Obellianne Viswanathan Palanisamy Vamsi K. Gangaraju J. Alan Diehl Philip H. Howe Tags: Addendum Source Type: research
Erratum: PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Nature Cell Biology 19, 1442 (2017).
doi:10.1038/ncb3648
Author: Fabao Liu, Fengfei Ma, Yuyuan Wang, Ling Hao, Hao Zeng, Chenxi Jia, Yidan Wang, Peng Liu, Irene M. Ong, Baobin Li, Guojun Chen, Jiaoyang Jiang, Shaoqin Gong, Lingjun Li & Wei Xu (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 29, 2017 Category: Cytology Authors: Fabao Liu Fengfei Ma Yuyuan Wang Ling Hao Hao Zeng Chenxi Jia Yidan Wang Peng Liu Irene M. Ong Baobin Li Guojun Chen Jiaoyang Jiang Shaoqin Gong Lingjun Li Wei Xu Tags: Erratum Source Type: research
Erratum: EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity
Nature Cell Biology 19, 1442 (2017).
doi:10.1038/ncb3646
Author: Zarah M. Löf-Öhlin, Pia Nyeng, Matthew E. Bechard, Katja Hess, Eric Bankaitis, Thomas U. Greiner, Jacqueline Ameri, Christopher V. Wright & Henrik Semb (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 29, 2017 Category: Cytology Authors: Zarah M. L ö f- Ö hlin Pia Nyeng Matthew E. Bechard Katja Hess Eric Bankaitis Thomas U. Greiner Jacqueline Ameri Christopher V. Wright Henrik Semb Tags: Erratum Source Type: research
Corrigendum: Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation
Nature Cell Biology 19, 1441 (2017).
doi:10.1038/ncb3651
Author: Yong-Jian Wang, Yan Bian, Jie Luo, Ming Lu, Ying Xiong, Shu-Yuan Guo, Hui Yong, Xu Lin, Qin Li, Catherine C. Y. Chang, Ta-Yuan Chang, Bo-Liang Li & Bao-Liang Song (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 29, 2017 Category: Cytology Authors: Yong-Jian Wang Yan Bian Jie Luo Ming Lu Ying Xiong Shu-Yuan Guo Hui Yong Xu Lin Qin Li Catherine C. Y. Chang Ta-Yuan Chang Bo-Liang Li Bao-Liang Song Tags: Corrigendum Source Type: research
Erratum: DNA sensing in senescence
Nature Cell Biology 19, 1441 (2017).
doi:10.1038/ncb3644
Author: Marina Ruiz de Galarreta & Amaia Lujambio (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 29, 2017 Category: Cytology Authors: Marina Ruiz de Galarreta Amaia Lujambio Tags: Erratum Source Type: research
F-actin organizes the nucleus
Nature Cell Biology 19, 1386 (2017).
doi:10.1038/ncb3650
Authors: Henna M. Moore & Maria K. Vartiainen
After mitosis, the nucleus must be rebuilt and chromatin decondensed to permit interphase genomic functions, but decondensation mechanisms are poorly understood. Now, the traditional cytoskeletal protein actin is shown to form transient nuclear filaments that are required for chromatin decondensation and nuclear expansion at mitotic exit. (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 29, 2017 Category: Cytology Authors: Henna M. Moore Maria K. Vartiainen Tags: News and Views Source Type: research
Capturing endosomal vesicles at the Golgi
Nature Cell Biology 19, 1384 (2017).
doi:10.1038/ncb3649
Authors: J. Christopher Fromme & Mary Munson
Membrane trafficking specificity between distinct compartments ensures that cargo proteins and lipids are delivered to their target organelle. However, accurate recognition of cargo carriers by tethering factors on target membranes is poorly understood. TBC1D23 is now identified as an adaptor that links endosome-derived vesicles with golgins at the trans-Golgi. (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 29, 2017 Category: Cytology Authors: J. Christopher Fromme Mary Munson Tags: News and Views Source Type: research
RNA takes over control of DNA break repair
Nature Cell Biology 19, 1382 (2017).
doi:10.1038/ncb3645
Authors: Francesca Storici & Ailone E. Tichon
Small RNAs generated at DNA break sites are implicated in mammalian DNA repair. Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions. (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 29, 2017 Category: Cytology Authors: Francesca Storici Ailone E. Tichon Tags: News and Views Source Type: research
Of stem cells and ethics
Nature Cell Biology 19, 1381 (2017).
doi:10.1038/ncb3652
Advances in stem cell research offer unprecedented insights into human biology and opportunities for clinical translation. They also raise many questions with social and ethical implications. (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 29, 2017 Category: Cytology Tags: Editorial Source Type: research
Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks
Nature Cell Biology 19, 1400 (2017).
doi:10.1038/ncb3643
Authors: Flavia Michelini, Sethuramasundaram Pitchiaya, Valerio Vitelli, Sheetal Sharma, Ubaldo Gioia, Fabio Pessina, Matteo Cabrini, Yejun Wang, Ilaria Capozzo, Fabio Iannelli, Valentina Matti, Sofia Francia, G. V. Shivashankar, Nils G. Walter & Fabrizio d’Adda di Fagagna (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 27, 2017 Category: Cytology Authors: Flavia Michelini Sethuramasundaram Pitchiaya Valerio Vitelli Sheetal Sharma Ubaldo Gioia Fabio Pessina Matteo Cabrini Yejun Wang Ilaria Capozzo Fabio Iannelli Valentina Matti Sofia Francia G. V. Shivashankar Nils G. Walter Fabrizio d ’ Adda di Fagagna Tags: Article Source Type: research
A transient pool of nuclear F-actin at mitotic exit controls chromatin organization
Nature Cell Biology 19, 1389 (2017).
doi:10.1038/ncb3641
Authors: Christian Baarlink, Matthias Plessner, Alice Sherrard, Kohtaro Morita, Shinji Misu, David Virant, Eva-Maria Kleinschnitz, Robert Harniman, Dominic Alibhai, Stefan Baumeister, Kei Miyamoto, Ulrike Endesfelder, Abderrahmane Kaidi & Robert Grosse (Source: Nature Cell Biology)
Source: Nature Cell Biology - November 13, 2017 Category: Cytology Authors: Christian Baarlink Matthias Plessner Alice Sherrard Kohtaro Morita Shinji Misu David Virant Eva-Maria Kleinschnitz Robert Harniman Dominic Alibhai Stefan Baumeister Kei Miyamoto Ulrike Endesfelder Abderrahmane Kaidi Robert Grosse Tags: Article Source Type: research
Erratum: Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome
Nature Cell Biology 19, 1379 (2017).
doi:10.1038/ncb3622
Author: Xiaoyu Shi, Galo Garcia, Julie C. Van De Weghe, Ryan McGorty, Gregory J. Pazour, Dan Doherty, Bo Huang & Jeremy F. Reiter (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 31, 2017 Category: Cytology Authors: Xiaoyu Shi Galo Garcia Julie C. Van De Weghe Ryan McGorty Gregory J. Pazour Dan Doherty Bo Huang Jeremy F. Reiter Tags: Erratum Source Type: research
TYRP1 mRNA goes fishing for miRNAs in melanoma
Nature Cell Biology 19, 1311 (2017).
doi:10.1038/ncb3637
Authors: Maria S. Soengas & Eva Hernando
A variety of non-coding RNAs have been reported as endogenous sponges for cancer-modulating miRNAs. However, miRNA trapping by transcripts with protein-coding functions is less understood. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16 on non-canonical miRNA response elements in melanoma, thereby promoting malignant growth. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 31, 2017 Category: Cytology Authors: Maria S. Soengas Eva Hernando Tags: News and Views Source Type: research
PARPi focus the spotlight on replication fork protection in cancer
Nature Cell Biology 19, 1309 (2017).
doi:10.1038/ncb3638
Author: Katharina Schlacher
PARP inhibitors (PARPi) kill BRCA1/2-mutated cancers, which become resistant when DNA repair functions are restored. Now, MUS81 nuclease inhibition due to EZH2 downregulation is found to restore DNA replication fork protection but not repair, leading to PARPi-resistance in mutant BRCA2 cells and patients. This challenges the DNA repair dominance in synthetic lethality. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 31, 2017 Category: Cytology Authors: Katharina Schlacher Tags: News and Views Source Type: research
Implantable synthetic organoid matrices for intestinal regeneration
Nature Cell Biology 19, 1307 (2017).
doi:10.1038/ncb3635
Authors: Jeffrey W. Brown & Jason C. Mills
Organoids are a powerful tool to study both physiological and disease processes. A completely synthetic matrix assembled from exchangeable modular parts has been developed and not only supports proliferation of human intestinal organoids derived from pluripotent embryonic stem cells, but also augments subsequent ad vivo implantation into injured murine colon. (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 31, 2017 Category: Cytology Authors: Jeffrey W. Brown Jason C. Mills Tags: News and Views Source Type: research
