Activation of the ATR kinase by the RPA-binding protein ETAA1
Nature Cell Biology 18, 1196 (2016).
doi:10.1038/ncb3422
Authors: Peter Haahr, Saskia Hoffmann, Maxim A. X. Tollenaere, Teresa Ho, Luis Ignacio Toledo, Matthias Mann, Simon Bekker-Jensen, Markus Räschle & Niels Mailand (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 9, 2016 Category: Cytology Authors: Peter Haahr Saskia Hoffmann Maxim A. X. Tollenaere Teresa Ho Luis Ignacio Toledo Matthias Mann Simon Bekker-Jensen Markus R äschle Niels Mailand Tags: Article Source Type: research
ETAA1 acts at stalled replication forks to maintain genome integrity
Nature Cell Biology 18, 1185 (2016).
doi:10.1038/ncb3415
Authors: Thomas E. Bass, Jessica W. Luzwick, Gina Kavanaugh, Clinton Carroll, Huzefa Dungrawala, Gloria G. Glick, Michael D. Feldkamp, Reid Putney, Walter J. Chazin & David Cortez (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 9, 2016 Category: Cytology Authors: Thomas E. Bass Jessica W. Luzwick Gina Kavanaugh Clinton Carroll Huzefa Dungrawala Gloria G. Glick Michael D. Feldkamp Reid Putney Walter J. Chazin David Cortez Tags: Article Source Type: research
Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network
Nature Cell Biology 18, 1139 (2016).
doi:10.1038/ncb3418
Authors: Nicola Festuccia, Agnès Dubois, Sandrine Vandormael-Pournin, Elena Gallego Tejeda, Adrien Mouren, Sylvain Bessonnard, Florian Mueller, Caroline Proux, Michel Cohen-Tannoudji & Pablo Navarro (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 9, 2016 Category: Cytology Authors: Nicola Festuccia Agn ès Dubois Sandrine Vandormael-Pournin Elena Gallego Tejeda Adrien Mouren Sylvain Bessonnard Florian Mueller Caroline Proux Michel Cohen-Tannoudji Pablo Navarro Tags: Article Source Type: research
Progress towards generation of human haematopoietic stem cells
Nature Cell Biology 18, 1111 (2016).
doi:10.1038/ncb3419
Authors: Lara Wahlster & George Q. Daley (Source: Nature Cell Biology)
Source: Nature Cell Biology - October 9, 2016 Category: Cytology Authors: Lara Wahlster George Q. Daley Tags: Perspective Source Type: research
An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function
Nature Cell Biology 18, 1244 (2016).
doi:10.1038/ncb3413
Authors: Weiyue Zheng, Masataka Umitsu, Ishaan Jagan, Charles W. Tran, Noboru Ishiyama, Michael BeGora, Kiyomi Araki, Pamela S. Ohashi, Mitsuhiko Ikura & Senthil K. Muthuswamy
The polarity protein Scribble (SCRIB) regulates apical–basal polarity, directional migration and tumour suppression in Drosophila and mammals. Here we report that SCRIB is an important regulator of myeloid cell functions including bacterial infection and inflammation. SCRIB interacts directly with the NADPH oxidase (NOX) complex in a PSD95/Dlg/ZO-1 (PDZ)-domain-dependent manne...
Source: Nature Cell Biology - October 2, 2016 Category: Cytology Authors: Weiyue Zheng Masataka Umitsu Ishaan Jagan Charles W. Tran Noboru Ishiyama Michael BeGora Kiyomi Araki Pamela S. Ohashi Mitsuhiko Ikura Senthil K. Muthuswamy Tags: Letter Source Type: research
Erratum: Sex hormones establish a reserve pool of adult muscle stem cells
Nature Cell Biology 18, 1109 (2016).
doi:10.1038/ncb3416
Author: Ji-Hoon Kim, Gi-Chan Han, Ji-Yun Seo, Inkuk Park, Wookjin Park, Hyun-Woo Jeong, Su Hyeon Lee, Sung-hwan Bae, Jinwoo Seong, Min-Kyu Yum, Sang-Hyeon Hann, Young-Guen Kwon, Daekwan Seo, Man Ho Choi & Young-Yun Kong (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 27, 2016 Category: Cytology Authors: Ji-Hoon Kim Gi-Chan Han Ji-Yun Seo Inkuk Park Wookjin Park Hyun-Woo Jeong Su Hyeon Lee Sung-hwan Bae Jinwoo Seong Min-Kyu Yum Sang-Hyeon Hann Young-Guen Kwon Daekwan Seo Man Ho Choi Young-Yun Kong Tags: Erratum Source Type: research
Regional tumour glutamine supply affects chromatin and cell identity
Nature Cell Biology 18, 1027 (2016).
doi:10.1038/ncb3414
Authors: Jonas W. Højfeldt & Kristian Helin
Limited perfusion of solid tumours produces a nutrient-deprived tumour core microenvironment. Low glutamine levels in the tumour core are now shown to lead to reduced levels of α-ketoglutarate and decreased histone demethylase activity, thereby promoting a less differentiated and more therapy-resistant state of the tumour cells. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 27, 2016 Category: Cytology Authors: Jonas W. H øjfeldt Kristian Helin Tags: News and Views Source Type: research
Turn up the lysosome
Nature Cell Biology 18, 1025 (2016).
doi:10.1038/ncb3409
Authors: Paul Saftig & Albert Haas
Lysosomes are digestive organelles of the endocytic and autophagic pathways. Increasing lysosome enzyme activities could help to clear pathological cellular waste. A recent study shows that lysosomal digestive functions can be promoted in isolated cells and mice by pharmacologically stimulating the autophagy- and lysosome-regulating transcription factors TFEB and ZKSCAN3 through previously unrecognized mTORC1-independent pathways acting via PKC. (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 27, 2016 Category: Cytology Authors: Paul Saftig Albert Haas Tags: News and Views Source Type: research
Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow
Nature Cell Biology 18, 1078 (2016).
doi:10.1038/ncb3408
Authors: Rachelle W. Johnson, Elizabeth C. Finger, Monica M. Olcina, Marta Vilalta, Todd Aguilera, Yu Miao, Alyssa R. Merkel, Joshua R. Johnson, Julie A. Sterling, Joy Y. Wu & Amato J. Giaccia (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 18, 2016 Category: Cytology Authors: Rachelle W. Johnson Elizabeth C. Finger Monica M. Olcina Marta Vilalta Todd Aguilera Yu Miao Alyssa R. Merkel Joshua R. Johnson Julie A. Sterling Joy Y. Wu Amato J. Giaccia Tags: Article Source Type: research
iPSC-derived cardiomyocytes reveal abnormal TGF- β signalling in left ventricular non-compaction cardiomyopathy
Nature Cell Biology 18, 1031 (2016).
doi:10.1038/ncb3411
Authors: Kazuki Kodo, Sang-Ging Ong, Fereshteh Jahanbani, Vittavat Termglinchan, Keiichi Hirono, Kolsoum InanlooRahatloo, Antje D. Ebert, Praveen Shukla, Oscar J. Abilez, Jared M. Churko, Ioannis Karakikes, Gwanghyun Jung, Fukiko Ichida, Sean M. Wu, Michael P. Snyder, Daniel Bernstein & Joseph C. Wu (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 18, 2016 Category: Cytology Authors: Kazuki Kodo Sang-Ging Ong Fereshteh Jahanbani Vittavat Termglinchan Keiichi Hirono Kolsoum InanlooRahatloo Antje D. Ebert Praveen Shukla Oscar J. Abilez Jared M. Churko Ioannis Karakikes Gwanghyun Jung Fukiko Ichida Sean M. Wu Michael P. Snyder Daniel Ber Tags: Article Source Type: research
EB1 interacts with outwardly curved and straight regions of the microtubule lattice
Nature Cell Biology 18, 1102 (2016).
doi:10.1038/ncb3412
Authors: Audrey Guesdon, Franck Bazile, Rubén M. Buey, Renu Mohan, Solange Monier, Ruddi Rodríguez García, Morgane Angevin, Claire Heichette, Ralph Wieneke, Robert Tampé, Laurence Duchesne, Anna Akhmanova, Michel O. Steinmetz & Denis Chrétien
EB1 is a microtubule plus-end tracking protein that recognizes GTP-tubulin dimers in microtubules and thus represents a unique probe to investigate the architecture of the GTP cap of growing microtubule ends. Here, we conjugated EB1 to gold nanoparticles (EB1-gold) and imaged by cryo-ele...
Source: Nature Cell Biology - September 11, 2016 Category: Cytology Authors: Audrey Guesdon Franck Bazile Rub én M. Buey Renu Mohan Solange Monier Ruddi Rodr íguez García Morgane Angevin Claire Heichette Ralph Wieneke Robert Tamp é Laurence Duchesne Anna Akhmanova Michel O. Steinmetz Denis Chr étien Tags: Letter Source Type: research
Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation
Nature Cell Biology 18, 1090 (2016).
doi:10.1038/ncb3410
Authors: Min Pan, Michael A. Reid, Xazmin H. Lowman, Rajan P. Kulkarni, Thai Q. Tran, Xiaojing Liu, Ying Yang, Jenny E. Hernandez-Davies, Kimberly K. Rosales, Haiqing Li, Willy Hugo, Chunying Song, Xiangdong Xu, Dustin E. Schones, David K. Ann, Viviana Gradinaru, Roger S. Lo, Jason W. Locasale & Mei Kong (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 11, 2016 Category: Cytology Authors: Min Pan Michael A. Reid Xazmin H. Lowman Rajan P. Kulkarni Thai Q. Tran Xiaojing Liu Ying Yang Jenny E. Hernandez-Davies Kimberly K. Rosales Haiqing Li Willy Hugo Chunying Song Xiangdong Xu Dustin E. Schones David K. Ann Viviana Gradinaru Roger S. Lo Jaso Tags: Article Source Type: research
Protein kinase C controls lysosome biogenesis independently of mTORC1
Nature Cell Biology 18, 1065 (2016).
doi:10.1038/ncb3407
Authors: Yang Li, Meng Xu, Xiao Ding, Chen Yan, Zhiqin Song, Lianwan Chen, Xiahe Huang, Xin Wang, Youli Jian, Guihua Tang, Changyong Tang, Yingtong Di, Shuzhen Mu, Xuezhao Liu, Kai Liu, Ting Li, Yingchun Wang, Long Miao, Weixiang Guo, Xiaojiang Hao & Chonglin Yang (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 11, 2016 Category: Cytology Authors: Yang Li Meng Xu Xiao Ding Chen Yan Zhiqin Song Lianwan Chen Xiahe Huang Xin Wang Youli Jian Guihua Tang Changyong Tang Yingtong Di Shuzhen Mu Xuezhao Liu Kai Liu Ting Li Yingchun Wang Long Miao Weixiang Guo Xiaojiang Hao Chonglin Yang Tags: Article Source Type: research
Self-repair promotes microtubule rescue
Nature Cell Biology 18, 1054 (2016).
doi:10.1038/ncb3406
Authors: Charlotte Aumeier, Laura Schaedel, Jérémie Gaillard, Karin John, Laurent Blanchoin & Manuel Théry (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 11, 2016 Category: Cytology Authors: Charlotte Aumeier Laura Schaedel J érémie Gaillard Karin John Laurent Blanchoin Manuel Th éry Tags: Article Source Type: research
Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling
Nature Cell Biology 18, 1043 (2016).
doi:10.1038/ncb3405
Authors: Sanguk Yun, Madhusudhan Budatha, James E. Dahlman, Brian G. Coon, Ryan T. Cameron, Robert Langer, Daniel G. Anderson, George Baillie & Martin A. Schwartz (Source: Nature Cell Biology)
Source: Nature Cell Biology - September 4, 2016 Category: Cytology Authors: Sanguk Yun Madhusudhan Budatha James E. Dahlman Brian G. Coon Ryan T. Cameron Robert Langer Daniel G. Anderson George Baillie Martin A. Schwartz Tags: Article Source Type: research
