Reversing stratification during wound healing
Nature Cell Biology 19, 595 (2017).
doi:10.1038/ncb3545
Author: Denis Headon
The involvement of proliferation and migration in epidermal healing has long been recognized, but three studies now reveal how a variety of individual cell behaviours achieve a collective epithelial response, and how diverse repair routes are taken by cells of different origins. (Source: Nature Cell Biology)
Source: Nature Cell Biology - May 31, 2017 Category: Cytology Authors: Denis Headon Tags: News and Views Source Type: research
Endoglin moves and shapes endothelial cells
Nature Cell Biology 19, 593 (2017).
doi:10.1038/ncb3543
Author: Victoria L. Bautch
Vascular malformations result from improper blood vessel responses to molecular and mechanical signals. Two studies now show that endothelial cell migration and cell shape changes are perturbed in mutants lacking the TGFβ/BMP co-receptor endoglin, leading to arteriovenous shunts. Endoglin coordinates endothelial cell responses to ligand–receptor signalling and flow-mediated mechanical cues. (Source: Nature Cell Biology)
Source: Nature Cell Biology - May 31, 2017 Category: Cytology Authors: Victoria L. Bautch Tags: News and Views Source Type: research
Cell forces meet cell metabolism
Nature Cell Biology 19, 591 (2017).
doi:10.1038/ncb3542
Authors: Tadamoto Isogai, Jin Suk Park & Gaudenz Danuser
Epithelial cells form energetically costly cell–cell adhesions in response to mechanical forces. How cells obtain their energy during this event is unclear. Activity of a key regulator of cell metabolism, the AMP-activated protein kinase (AMPK), is now shown to be mechanoresponsive, and thus can bridge adhesion mechanotransduction and energy homeostasis. (Source: Nature Cell Biology)
Source: Nature Cell Biology - May 31, 2017 Category: Cytology Authors: Tadamoto Isogai Jin Suk Park Gaudenz Danuser Tags: News and Views Source Type: research
Mitochondria link metabolism and epigenetics in haematopoiesis
Nature Cell Biology 19, 589 (2017).
doi:10.1038/ncb3540
Authors: John C. Schell & Jared Rutter
Due to their varied metabolic and signalling roles, mitochondria are important in mediating cell behaviour. By altering mitochondrial function, two studies now identify metabolite-induced epigenetic changes that have profound effects on haematopoietic stem cell fate and function. (Source: Nature Cell Biology)
Source: Nature Cell Biology - May 31, 2017 Category: Cytology Authors: John C. Schell Jared Rutter Tags: News and Views Source Type: research
Multiscale force sensing in development
Nature Cell Biology 19, 581 (2017).
doi:10.1038/ncb3524
Authors: Nicoletta I. Petridou, Zoltán Spiró & Carl-Philipp Heisenberg (Source: Nature Cell Biology)
Source: Nature Cell Biology - May 31, 2017 Category: Cytology Authors: Nicoletta I. Petridou Zolt á n Spir ó Carl-Philipp Heisenberg Tags: Review Source Type: research
Championing authorship attribution
Nature Cell Biology 19, 579 (2017).
doi:10.1038/ncb3553
Nature Cell Biology is among the Springer Nature journals taking part in a recently launched trial that mandates the provision of ORCID identifiers for the corresponding authors of our papers. (Source: Nature Cell Biology)
Source: Nature Cell Biology - May 31, 2017 Category: Cytology Tags: Editorial Source Type: research
Forces in cell biology
Nature Cell Biology 19, 579 (2017).
doi:10.1038/ncb3552
Mechanobiology — the study of how physical forces control the behaviour of cells and tissues — is a rapidly growing field. In this issue, we launch a Series of specially commissioned Review articles that discuss exciting recent developments in this area. (Source: Nature Cell Biology)
Source: Nature Cell Biology - May 31, 2017 Category: Cytology Tags: Editorial Source Type: research
The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing PXN expression through the alternative splicing of lncRNA-PXN-AS1
Nature Cell Biology 19, 820 (2017).
doi:10.1038/ncb3538
Authors: Ji-hang Yuan, Xiao-ning Liu, Tian-tian Wang, Wei Pan, Qi-fei Tao, Wei-ping Zhou, Fang Wang & Shu-han Sun (Source: Nature Cell Biology)
Source: Nature Cell Biology - May 29, 2017 Category: Cytology Authors: Ji-hang Yuan Xiao-ning Liu Tian-tian Wang Wei Pan Qi-fei Tao Wei-ping Zhou Fang Wang Shu-han Sun Tags: Article Source Type: research
Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK
Nature Cell Biology 19, 724 (2017).
doi:10.1038/ncb3537
Authors: Jennifer L. Bays, Hannah K. Campbell, Christy Heidema, Michael Sebbagh & Kris A. DeMali
The response of cells to mechanical force is a major determinant of cell behaviour and is an energetically costly event. How cells derive energy to resist mechanical force is unknown. Here, we show that application of force to E-cadherin stimulates liver kinase B1 (LKB1) to activate AMP-activated protein kinase (AMPK), a master regulator of energy homeostasis. LKB1 recruits AMPK to the E-cadherin mechanotransduction complex, thereby stimulating actomyosin contr...
Source: Nature Cell Biology - May 29, 2017 Category: Cytology Authors: Jennifer L. Bays Hannah K. Campbell Christy Heidema Michael Sebbagh Kris A. DeMali Tags: Letter Source Type: research
Stem cell plasticity enables hair regeneration following Lgr5+ cell loss
Nature Cell Biology 19, 666 (2017).
doi:10.1038/ncb3535
Authors: Joerg D. Hoeck, Brian Biehs, Antonina V. Kurtova, Noelyn M. Kljavin, Felipe de Sousa e Melo, Bruno Alicke, Hartmut Koeppen, Zora Modrusan, Robert Piskol & Frederic J. de Sauvage (Source: Nature Cell Biology)
Source: Nature Cell Biology - May 29, 2017 Category: Cytology Authors: Joerg D. Hoeck Brian Biehs Antonina V. Kurtova Noelyn M. Kljavin Felipe de Sousa e Melo Bruno Alicke Hartmut Koeppen Zora Modrusan Robert Piskol Frederic J. de Sauvage Tags: Article Source Type: research
Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a – LCOR axis
Nature Cell Biology 19, 711 (2017).
doi:10.1038/ncb3533
Authors: Toni Celià-Terrassa, Daniel D. Liu, Abrar Choudhury, Xiang Hang, Yong Wei, Jose Zamalloa, Raymundo Alfaro-Aco, Rumela Chakrabarti, Yi-Zhou Jiang, Bong Ihn Koh, Heath A. Smith, Christina DeCoste, Jun-Jing Li, Zhi-Ming Shao & Yibin Kang (Source: Nature Cell Biology)
Source: Nature Cell Biology - May 22, 2017 Category: Cytology Authors: Toni Celi à -Terrassa Daniel D. Liu Abrar Choudhury Xiang Hang Yong Wei Jose Zamalloa Raymundo Alfaro-Aco Rumela Chakrabarti Yi-Zhou Jiang Bong Ihn Koh Heath A. Smith Christina DeCoste Jun-Jing Li Zhi-Ming Shao Yibin Kang Tags: Article Source Type: research
Actin cortex architecture regulates cell surface tension
Nature Cell Biology 19, 689 (2017).
doi:10.1038/ncb3525
Authors: Priyamvada Chugh, Andrew G. Clark, Matthew B. Smith, Davide A. D. Cassani, Kai Dierkes, Anan Ragab, Philippe P. Roux, Guillaume Charras, Guillaume Salbreux & Ewa K. Paluch (Source: Nature Cell Biology)
Source: Nature Cell Biology - May 22, 2017 Category: Cytology Authors: Priyamvada Chugh Andrew G. Clark Matthew B. Smith Davide A. D. Cassani Kai Dierkes Anan Ragab Philippe P. Roux Guillaume Charras Guillaume Salbreux Ewa K. Paluch Tags: Article Source Type: research
Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues
Nature Cell Biology 19, 653 (2017).
doi:10.1038/ncb3528
Authors: Wade W. Sugden, Robert Meissner, Tinri Aegerter-Wilmsen, Roman Tsaryk, Elvin V. Leonard, Jeroen Bussmann, Mailin J. Hamm, Wiebke Herzog, Yi Jin, Lars Jakobsson, Cornelia Denz & Arndt F. Siekmann (Source: Nature Cell Biology)
Source: Nature Cell Biology - May 22, 2017 Category: Cytology Authors: Wade W. Sugden Robert Meissner Tinri Aegerter-Wilmsen Roman Tsaryk Elvin V. Leonard Jeroen Bussmann Mailin J. Hamm Wiebke Herzog Yi Jin Lars Jakobsson Cornelia Denz Arndt F. Siekmann Tags: Article Source Type: research
Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling
Nature Cell Biology 19, 639 (2017).
doi:10.1038/ncb3534
Authors: Yi Jin, Lars Muhl, Mikhail Burmakin, Yixin Wang, Anne-Claire Duchez, Christer Betsholtz, Helen M. Arthur & Lars Jakobsson (Source: Nature Cell Biology)
Source: Nature Cell Biology - May 22, 2017 Category: Cytology Authors: Yi Jin Lars Muhl Mikhail Burmakin Yixin Wang Anne-Claire Duchez Christer Betsholtz Helen M. Arthur Lars Jakobsson Tags: Article Source Type: research
Receptor oligomerization guides pathway choice between proteasomal and autophagic degradation
Nature Cell Biology 19, 732 (2017).
doi:10.1038/ncb3531
Authors: Kefeng Lu, Fabian den Brave & Stefan Jentsch
Abnormal or aggregated proteins have a strong cytotoxic potential and are causative for human disorders such as Alzheimer’s, Parkinson’s, Huntington’s disease and amyotrophic lateral sclerosis. If not restored by molecular chaperones, abnormal proteins are typically degraded by proteasomes or eliminated by selective autophagy. The discovery that both pathways are initiated by substrate ubiquitylation but utilize different ubiquitin receptors incited a debate over how pathway choice is ...
Source: Nature Cell Biology - May 15, 2017 Category: Cytology Authors: Kefeng Lu Fabian den Brave Stefan Jentsch Tags: Letter Source Type: research
