Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing
Nature Cell Biology 18, 823 (2016). doi:10.1038/ncb3385 Authors: Navdeep S. Chandel, Heinrich Jasper, Theodore T. Ho & Emmanuelle Passegué (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 17, 2016 Category: Cytology Authors: Navdeep S. Chandel Heinrich Jasper Theodore T. Ho Emmanuelle Passegu é Tags: Review Source Type: research

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage  commitment
Nature Cell Biology 18, 864 (2016). doi:10.1038/ncb3387 Authors: Huy Quang Le, Sushmita Ghatak, Ching-Yan Chloé Yeung, Frederik Tellkamp, Christian Günschmann, Christoph Dieterich, Assa Yeroslaviz, Bianca Habermann, Ana Pombo, Carien M. Niessen & Sara A. Wickström (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 10, 2016 Category: Cytology Authors: Huy Quang Le Sushmita Ghatak Ching-Yan Chlo é Yeung Frederik Tellkamp Christian G ünschmann Christoph Dieterich Assa Yeroslaviz Bianca Habermann Ana Pombo Carien M. Niessen Sara A. Wickstr öm Tags: Article Source Type: research

Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF- β-induced autophagy
Nature Cell Biology 18, 851 (2016). doi:10.1038/ncb3388 Authors: Yong Jiang, Alec N. Woosley, Nageswaran Sivalingam, Sneha Natarajan & Philip H. Howe (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 10, 2016 Category: Cytology Authors: Yong Jiang Alec N. Woosley Nageswaran Sivalingam Sneha Natarajan Philip H. Howe Tags: Article Source Type: research

Autophagosome –lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL
Nature Cell Biology 18, 839 (2016). doi:10.1038/ncb3386 Authors: Maria Giovanna De Leo, Leopoldo Staiano, Mariella Vicinanza, Alessandro Luciani, Annamaria Carissimo, Margherita Mutarelli, Antonella Di Campli, Elena Polishchuk, Giuseppe Di Tullio, Valentina Morra, Elena Levtchenko, Francesca Oltrabella, Tobias Starborg, Michele Santoro, Diego di Bernardo, Olivier Devuyst, Martin Lowe, Diego L. Medina, Andrea Ballabio & Maria Antonietta De Matteis (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 10, 2016 Category: Cytology Authors: Maria Giovanna De Leo Leopoldo Staiano Mariella Vicinanza Alessandro Luciani Annamaria Carissimo Margherita Mutarelli Antonella Di Campli Elena Polishchuk Giuseppe Di Tullio Valentina Morra Elena Levtchenko Francesca Oltrabella Tobias Starborg Michele San Tags: Article Source Type: research

Erratum: Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation
Nature Cell Biology 18, 822 (2016). doi:10.1038/ncb3379 Author: Thomas Welte, Ik Sun Kim, Lin Tian, Xia Gao, Hai Wang, June Li, Xue B. Holdman, Jason I. Herschkowitz, Adam Pond, Guorui Xie, Sarah Kurley, Tuan Nguyen, Lan Liao, Lacey E. Dobrolecki, Lan Pang, Qianxing Mo, Dean P. Edwards, Shixia Huang, Li Xin, Jianming Xu, Yi Li, Michael T. Lewis, Tian Wang, Thomas F. Westbrook, Jeffrey M. Rosen & Xiang H.-F. Zhang (Source: Nature Cell Biology)
Source: Nature Cell Biology - June 27, 2016 Category: Cytology Authors: Thomas WelteIk Sun KimLin TianXia GaoHai WangJune LiXue B. HoldmanJason I. HerschkowitzAdam PondGuorui XieSarah KurleyTuan NguyenLan LiaoLacey E. DobroleckiLan PangQianxing MoDean P. EdwardsShixia HuangLi XinJianming XuYi LiMichael T. LewisTian WangThomas Tags: Erratum Source Type: research

Corrigendum: Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis
Nature Cell Biology 18, 822 (2016). doi:10.1038/ncb3377 Author: Sebastian R. Nielsen, Valeria Quaranta, Andrea Linford, Perpetua Emeagi, Carolyn Rainer, Almudena Santos, Lucy Ireland, Takao Sakai, Keiko Sakai, Yong-Sam Kim, Dannielle Engle, Fiona Campbell, Daniel Palmer, Jeong Heon Ko, David A. Tuveson, Emilio Hirsch, Ainhoa Mielgo & Michael C. Schmid (Source: Nature Cell Biology)
Source: Nature Cell Biology - June 27, 2016 Category: Cytology Authors: Sebastian R. NielsenValeria QuarantaAndrea LinfordPerpetua EmeagiCarolyn RainerAlmudena SantosLucy IrelandTakao SakaiKeiko SakaiYong-Sam KimDannielle EngleFiona CampbellDaniel PalmerJeong Heon KoDavid A. TuvesonEmilio HirschAinhoa MielgoMichael C. Schmid Tags: Corrigendum Source Type: research

New MAPS for misfolded proteins
Nature Cell Biology 18, 724 (2016). doi:10.1038/ncb3381 Authors: Norbert Volkmar, Emma Fenech & John C. Christianson Clearing misfolded proteins from the cytoplasm is essential to maintain cellular homeostasis. Now, a parallel clearance system is described that uses the deubiquitylase USP19 to enable secretion of misfolded cytoplasmic proteins when conventional proteasomal degradation is compromised. Misfolding-associated protein secretion (MAPS) has important implications for protein quality control and prion-like transmission. (Source: Nature Cell Biology)
Source: Nature Cell Biology - June 27, 2016 Category: Cytology Authors: Norbert VolkmarEmma FenechJohn C. Christianson Tags: News and Views Source Type: research

p21 shapes cancer evolution
Nature Cell Biology 18, 722 (2016). doi:10.1038/ncb3382 Authors: Vasily S. Romanov & K. Lenhard Rudolph Although known to induce cellular senescence, an important tumour suppressor mechanism, mutation of CDKN1A — the gene encoding p21 (also known as WAF1 or CIP1) — is rare in human cancers. Now, a study reports a previously unappreciated oncogenic effect of p21 overexpression that shapes cancer genome evolution through induction of replication stress. (Source: Nature Cell Biology)
Source: Nature Cell Biology - June 27, 2016 Category: Cytology Authors: Vasily S. RomanovK. Lenhard Rudolph Tags: News and Views Source Type: research

Mapping the molecular steps of secretory-lysosome-driven tracheal tube fusion
Nature Cell Biology 18, 720 (2016). doi:10.1038/ncb3383 Authors: Vahap Aydogan, Heinz-Georg Belting & Markus Affolter During development, tubular networks form through the joining of lumenized branches. Further insights into tracheal tube fusion in Drosophila melanogaster now reveal the molecular steps that promote the connection of two apical membrane compartments within a single cell through secretory lysosomes. (Source: Nature Cell Biology)
Source: Nature Cell Biology - June 27, 2016 Category: Cytology Authors: Vahap AydoganHeinz-Georg BeltingMarkus Affolter Tags: News and Views Source Type: research

Rewiring macrophages for anti-tumour immunity
Nature Cell Biology 18, 718 (2016). doi:10.1038/ncb3384 Authors: Yunqin Lee & Subhra K. Biswas Tumour-associated macrophages facilitate cancer progression, but whether they can be reprogrammed to elicit an anti-tumour response remains unclear. Deletion of the microRNA-processing enzyme Dicer is now shown to rewire macrophages to an anti-tumour mode, leading to an enhanced response to immunotherapy and inhibition of tumour progression. (Source: Nature Cell Biology)
Source: Nature Cell Biology - June 27, 2016 Category: Cytology Authors: Yunqin LeeSubhra K. Biswas Tags: News and Views Source Type: research

Cilium assembly and disassembly
Nature Cell Biology 18, 711 (2016). doi:10.1038/ncb3370 Authors: Irma Sánchez & Brian David Dynlacht (Source: Nature Cell Biology)
Source: Nature Cell Biology - June 27, 2016 Category: Cytology Authors: Irma SánchezBrian David Dynlacht Tags: Review Source Type: research

Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer
Nature Cell Biology 18, 897 (2016). doi:10.1038/ncb3380 Authors: Dawid Walerych, Kamil Lisek, Roberta Sommaggio, Silvano Piazza, Yari Ciani, Emiliano Dalla, Katarzyna Rajkowska, Katarzyna Gaweda-Walerych, Eleonora Ingallina, Claudia Tonelli, Marco J. Morelli, Angela Amato, Vincenzo Eterno, Alberto Zambelli, Antonio Rosato, Bruno Amati, Jacek R. Wiśniewski & Giannino Del Sal (Source: Nature Cell Biology)
Source: Nature Cell Biology - June 26, 2016 Category: Cytology Authors: Dawid Walerych Kamil Lisek Roberta Sommaggio Silvano Piazza Yari Ciani Emiliano Dalla Katarzyna Rajkowska Katarzyna Gaweda-Walerych Eleonora Ingallina Claudia Tonelli Marco J. Morelli Angela Amato Vincenzo Eterno Alberto Zambelli Antonio Rosato Bruno Amat Tags: Article Source Type: research

Staccato/Unc-13-4 controls secretory lysosome-mediated lumen fusion during epithelial tube  anastomosis
Nature Cell Biology 18, 727 (2016). doi:10.1038/ncb3374 Authors: Sara Caviglia, Marko Brankatschk, Elisabeth J. Fischer, Suzanne Eaton & Stefan Luschnig (Source: Nature Cell Biology)
Source: Nature Cell Biology - June 19, 2016 Category: Cytology Authors: Sara Caviglia Marko Brankatschk Elisabeth J. Fischer Suzanne Eaton Stefan Luschnig Tags: Article Source Type: research

PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia
Nature Cell Biology 18, 803 (2016). doi:10.1038/ncb3376 Authors: Robert S. Banh, Caterina Iorio, Richard Marcotte, Yang Xu, Dan Cojocari, Anas Abdel Rahman, Judy Pawling, Wei Zhang, Ankit Sinha, Christopher M. Rose, Marta Isasa, Shuang Zhang, Ronald Wu, Carl Virtanen, Toshiaki Hitomi, Toshiyuki Habu, Sachdev S. Sidhu, Akio Koizumi, Sarah E. Wilkins, Thomas Kislinger, Steven P. Gygi, Christopher J. Schofield, James W. Dennis, Bradly G. Wouters & Benjamin G. Neel (Source: Nature Cell Biology)
Source: Nature Cell Biology - June 19, 2016 Category: Cytology Authors: Robert S. BanhCaterina IorioRichard MarcotteYang XuDan CojocariAnas Abdel RahmanJudy PawlingWei ZhangAnkit SinhaChristopher M. RoseMarta IsasaShuang ZhangRonald WuCarl VirtanenToshiaki HitomiToshiyuki HabuSachdev S. SidhuAkio KoizumiSarah E. WilkinsThomas Tags: Article Source Type: research

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing
Nature Cell Biology 18, 777 (2016). doi:10.1038/ncb3378 Authors: Panagiotis Galanos, Konstantinos Vougas, David Walter, Alexander Polyzos, Apolinar Maya-Mendoza, Emma J. Haagensen, Antonis Kokkalis, Fani-Marlen Roumelioti, Sarantis Gagos, Maria Tzetis, Begoña Canovas, Ana Igea, Akshay K. Ahuja, Ralph Zellweger, Sofia Havaki, Emanuel Kanavakis, Dimitris Kletsas, Igor B. Roninson, Spiros D. Garbis, Massimo Lopes, Angel Nebreda, Dimitris Thanos, J. Julian Blow, Paul Townsend, Claus Storgaard Sørensen, Jiri Bartek & Vassilis G. Gorgoulis (Source: Nature Cell Biology)
Source: Nature Cell Biology - June 19, 2016 Category: Cytology Authors: Panagiotis GalanosKonstantinos VougasDavid WalterAlexander PolyzosApolinar Maya-MendozaEmma J. HaagensenAntonis KokkalisFani-Marlen RoumeliotiSarantis GagosMaria TzetisBegoña CanovasAna IgeaAkshay K. AhujaRalph ZellwegerSofia HavakiEmanuel KanavakisDimit Tags: Article Source Type: research