The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation
Nature Cell Biology 19, 384 (2017).
doi:10.1038/ncb3486
Authors: Justin Decarreau, Michael Wagenbach, Eric Lynch, Aaron R. Halpern, Joshua C. Vaughan, Justin Kollman & Linda Wordeman
Microtubules tether centrosomes together during interphase. How this is accomplished and what benefit it provides to the cell is not known. We have identified a bipolar, minus-end-directed kinesin, Kif25, that suppresses centrosome separation. Kif25 is required to prevent premature centrosome separation during interphase. We show that premature centrosome separation leads to microtubule-dependent nuclear translocation, culminating ...
Source: Nature Cell Biology - March 6, 2017 Category: Cytology Authors: Justin Decarreau Michael Wagenbach Eric Lynch Aaron R. Halpern Joshua C. Vaughan Justin Kollman Linda Wordeman Tags: Letter Source Type: research
SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras
Nature Cell Biology 19, 292 (2017).
doi:10.1038/ncb3487
Authors: Johanna Lilja, Thomas Zacharchenko, Maria Georgiadou, Guillaume Jacquemet, Nicola De Franceschi, Emilia Peuhu, Hellyeh Hamidi, Jeroen Pouwels, Victoria Martens, Fatemeh Hassani Nia, Malte Beifuss, Tobias Boeckers, Hans-Juergen Kreienkamp, Igor L. Barsukov & Johanna Ivaska (Source: Nature Cell Biology)
Source: Nature Cell Biology - March 6, 2017 Category: Cytology Authors: Johanna Lilja Thomas Zacharchenko Maria Georgiadou Guillaume Jacquemet Nicola De Franceschi Emilia Peuhu Hellyeh Hamidi Jeroen Pouwels Victoria Martens Fatemeh Hassani Nia Malte Beifuss Tobias Boeckers Hans-Juergen Kreienkamp Igor L. Barsukov Johann Tags: Article Source Type: research
Genomic instability during reprogramming by nuclear transfer is DNA replication dependent
Nature Cell Biology 19, 282 (2017).
doi:10.1038/ncb3485
Authors: Gloryn Chia, Judith Agudo, Nathan Treff, Mark V. Sauer, David Billing, Brian D. Brown, Richard Baer & Dieter Egli (Source: Nature Cell Biology)
Source: Nature Cell Biology - March 6, 2017 Category: Cytology Authors: Gloryn Chia Judith Agudo Nathan Treff Mark V. Sauer David Billing Brian D. Brown Richard Baer Dieter Egli Tags: Article Source Type: research
Erratum: Long-range self-organization of cytoskeletal myosin II filament stacks
Nature Cell Biology 19, 258 (2017).
doi:10.1038/ncb3479
Author: Shiqiong Hu, Kinjal Dasbiswas, Zhenhuan Guo, Yee-Han Tee, Visalatchi Thiagarajan, Pascal Hersen, Teng-Leong Chew, Samuel A. Safran, Ronen Zaidel-Bar & Alexander D. Bershadsky (Source: Nature Cell Biology)
Source: Nature Cell Biology - February 27, 2017 Category: Cytology Authors: Shiqiong Hu Kinjal Dasbiswas Zhenhuan Guo Yee-Han Tee Visalatchi Thiagarajan Pascal Hersen Teng-Leong Chew Samuel A. Safran Ronen Zaidel-Bar Alexander D. Bershadsky Tags: Erratum Source Type: research
Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice
Nature Cell Biology 19, 155 (2017).
doi:10.1038/ncb3472
Authors: Sangbum Park, David G. Gonzalez, Boris Guirao, Jonathan D. Boucher, Katie Cockburn, Edward D. Marsh, Kailin R. Mesa, Samara Brown, Panteleimon Rompolas, Ann M. Haberman, Yohanns Bellaïche & Valentina Greco (Source: Nature Cell Biology)
Source: Nature Cell Biology - February 27, 2017 Category: Cytology Authors: Sangbum Park David G. Gonzalez Boris Guirao Jonathan D. Boucher Katie Cockburn Edward D. Marsh Kailin R. Mesa Samara Brown Panteleimon Rompolas Ann M. Haberman Yohanns Bella ïche Valentina Greco Tags: Article Source Type: research
Twist of fate for skeletal muscle mesenchymal cells
Nature Cell Biology 19, 153 (2017).
doi:10.1038/ncb3482
Authors: Natalya A. Goloviznina & Michael Kyba
Skeletal muscles are composed of different types of fibres. Can these be thought of as distinct lineages with specific lineage-restricted progenitors? A provocative study now proposes that mesenchymal cells expressing the transcription factor Twist2 act as myogenic progenitors with selective type IIb fibre-differentiation potential. (Source: Nature Cell Biology)
Source: Nature Cell Biology - February 27, 2017 Category: Cytology Authors: Natalya A. Goloviznina Michael Kyba Tags: News and Views Source Type: research
Inheritance of protection from osmotic stress
Nature Cell Biology 19, 151 (2017).
doi:10.1038/ncb3483
Authors: Kiyomi R. Kaneshiro & Susan Strome
Exposure of mother worms to mild osmotic stress induces gene expression changes in offspring that protect them from strong osmotic stress. Inheritance of protection is now shown to depend on altered insulin-like signalling in the maternal germline, which confers protection through increased expression of zygotic gpdh-2, a rate-limiting enzyme in glycerol biosynthesis. (Source: Nature Cell Biology)
Source: Nature Cell Biology - February 27, 2017 Category: Cytology Authors: Kiyomi R. Kaneshiro Susan Strome Tags: News and Views Source Type: research
G1 cyclins protect pluripotency
Nature Cell Biology 19, 149 (2017).
doi:10.1038/ncb3480
Authors: Julia Arand & Julien Sage
G1 cyclins are considered essential for DNA replication and cell division. A recent report now shows that some cells can cycle in the absence of G1 cyclins. In embryonic stem cells and cancer cells, G1 cyclins are required to activate cyclin-dependent kinases to phosphorylate core pluripotency factors and maintain pluripotency. (Source: Nature Cell Biology)
Source: Nature Cell Biology - February 27, 2017 Category: Cytology Authors: Julia Arand Julien Sage Tags: News and Views Source Type: research
Pulling cells out of tumours
Nature Cell Biology 19, 147 (2017).
doi:10.1038/ncb3484
Author: Andrew J. Ewald
Tumours are highly complex and contain multiple cell types. Cancer-associated fibroblasts are now shown to have a critical role in directly leading cancer cell invasion. This intercellular interaction relies on a mechanically active cadherin-based junction, and CAF-led invasion is demonstrated to require E-cadherin in the cancer cell. (Source: Nature Cell Biology)
Source: Nature Cell Biology - February 27, 2017 Category: Cytology Authors: Andrew J. Ewald Tags: News and Views Source Type: research
The scientist citizen: time to become political
Nature Cell Biology 19, 145 (2017).
doi:10.1038/ncb3489
Shifting political landscapes in the United States and European Union have seeded uncertainty in the scientific community. Intellectual freedom, funding and scientist mobility must be protected to secure the future of biological research. (Source: Nature Cell Biology)
Source: Nature Cell Biology - February 27, 2017 Category: Cytology Tags: Editorial Source Type: research
Tubulin acetylation protects long-lived microtubules against mechanical ageing
Nature Cell Biology 19, 391 (2017).
doi:10.1038/ncb3481
Authors: Didier Portran, Laura Schaedel, Zhenjie Xu, Manuel Théry & Maxence V. Nachury
Long-lived microtubules endow the eukaryotic cell with long-range transport abilities. While long-lived microtubules are acetylated on Lys40 of α-tubulin (αK40), acetylation takes place after stabilization and does not protect against depolymerization. Instead, αK40 acetylation has been proposed to mechanically stabilize microtubules. Yet how modification of αK40, a residue exposed to the microtubule lumen and inaccessible to microtubule-ass...
Source: Nature Cell Biology - February 27, 2017 Category: Cytology Authors: Didier Portran Laura Schaedel Zhenjie Xu Manuel Th éry Maxence V. Nachury Tags: Letter Source Type: research
A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion
Nature Cell Biology 19, 224 (2017).
doi:10.1038/ncb3478
Authors: Anna Labernadie, Takuya Kato, Agustí Brugués, Xavier Serra-Picamal, Stefanie Derzsi, Esther Arwert, Anne Weston, Victor González-Tarragó, Alberto Elosegui-Artola, Lorenzo Albertazzi, Jordi Alcaraz, Pere Roca-Cusachs, Erik Sahai & Xavier Trepat (Source: Nature Cell Biology)
Source: Nature Cell Biology - February 19, 2017 Category: Cytology Authors: Anna Labernadie Takuya Kato Agust í Brugués Xavier Serra-Picamal Stefanie Derzsi Esther Arwert Anne Weston Victor Gonz ález-Tarragó Alberto Elosegui-Artola Lorenzo Albertazzi Jordi Alcaraz Pere Roca-Cusachs Erik Sahai Xavier Trepat Tags: Article Source Type: research
Differential cytokine contributions of perivascular haematopoietic stem cell niches
Nature Cell Biology 19, 214 (2017).
doi:10.1038/ncb3475
Authors: Noboru Asada, Yuya Kunisaki, Halley Pierce, Zichen Wang, Nicolas F. Fernandez, Alexander Birbrair, Avi Ma’ayan & Paul S. Frenette (Source: Nature Cell Biology)
Source: Nature Cell Biology - February 19, 2017 Category: Cytology Authors: Noboru Asada Yuya Kunisaki Halley Pierce Zichen Wang Nicolas F. Fernandez Alexander Birbrair Avi Ma ’ayan Paul S. Frenette Tags: Article Source Type: research
A Twist2-dependent progenitor cell contributes to adult skeletal muscle
Nature Cell Biology 19, 202 (2017).
doi:10.1038/ncb3477
Authors: Ning Liu, Glynnis A. Garry, Stephen Li, Svetlana Bezprozvannaya, Efrain Sanchez-Ortiz, Beibei Chen, John M. Shelton, Priscilla Jaichander, Rhonda Bassel-Duby & Eric N. Olson (Source: Nature Cell Biology)
Source: Nature Cell Biology - February 19, 2017 Category: Cytology Authors: Ning Liu Glynnis A. Garry Stephen Li Svetlana Bezprozvannaya Efrain Sanchez-Ortiz Beibei Chen John M. Shelton Priscilla Jaichander Rhonda Bassel-Duby Eric N. Olson Tags: Article Source Type: research
Cell –matrix signals specify bone endothelial cells during developmental osteogenesis
Nature Cell Biology 19, 189 (2017).
doi:10.1038/ncb3476
Authors: Urs H. Langen, Mara E. Pitulescu, Jung Mo Kim, Rocio Enriquez-Gasca, Kishor K. Sivaraj, Anjali P. Kusumbe, Amit Singh, Jacopo Di Russo, M. Gabriele Bixel, Bin Zhou, Lydia Sorokin, Juan M. Vaquerizas & Ralf H. Adams (Source: Nature Cell Biology)
Source: Nature Cell Biology - February 19, 2017 Category: Cytology Authors: Urs H. Langen Mara E. Pitulescu Jung Mo Kim Rocio Enriquez-Gasca Kishor K. Sivaraj Anjali P. Kusumbe Amit Singh Jacopo Di Russo M. Gabriele Bixel Bin Zhou Lydia Sorokin Juan M. Vaquerizas Ralf H. Adams Tags: Article Source Type: research
