Rho/ROCK acts downstream of lysophosphatidic acid receptor 1 in modulating P2X3 receptor-mediated bone cancer pain in rats
Conclusions
Lysophosphatidic acid and its receptor LPAR1, acting through the Rho-ROCK pathway, regulate P2X3 receptor in the development of both mechanical and spontaneous pain in bone cancer. (Source: Molecular Pain)
Source: Molecular Pain - April 17, 2016 Category: Molecular Biology Authors: Wu, J.-x., Yuan, X.-m., Wang, Q., Wei, W., Xu, M.-y. Tags: Research Article Source Type: research
Interferon-gamma potentiates NMDA receptor signaling in spinal dorsal horn neurons via microglia-neuron interaction
Conclusion
Our findings suggest that IFN enhance the amplitude of NMDA-induced inward currents in substantia gelatinosa neurons via microglial IFN receptors and CCL2/CCR2 signaling. This mechanism might be partially responsible for the development of persistent neuropathic pain. (Source: Molecular Pain)
Source: Molecular Pain - April 17, 2016 Category: Molecular Biology Authors: Sonekatsu, M., Taniguchi, W., Yamanaka, M., Nishio, N., Tsutsui, S., Yamada, H., Yoshida, M., Nakatsuka, T. Tags: Research Article Source Type: research
Effects of Src-kinase inhibition in cancer-induced bone pain
Conclusions
This is the first demonstration that Src plays a role in the development of cancer-induced bone pain and that Src inhibition represents a possible new analgesic strategy for patients with bone metastases. (Source: Molecular Pain)
Source: Molecular Pain - April 17, 2016 Category: Molecular Biology Authors: De Felice, M., Lambert, D., Holen, I., Escott, K. J., Andrew, D. Tags: Research Article Source Type: research
Epigenetic regulation of spinal cord gene expression contributes to enhanced postoperative pain and analgesic tolerance subsequent to continuous opioid exposure
Conclusions
Spinal epigenetic changes involving Bdnf and Pdyn may contribute to the enhanced postoperative nociceptive sensitization and analgesic tolerance observed after continuous opioid exposure. Treatments blocking the epigenetically mediated up-regulation of these genes or administration of TrkB or -opioid receptor antagonists may improve the clinical utility of opioids, particularly after surgery. (Source: Molecular Pain)
Source: Molecular Pain - April 17, 2016 Category: Molecular Biology Authors: Sahbaie, P., Liang, D.-Y., Shi, X.-Y., Sun, Y., Clark, J. D. Tags: Research Article Source Type: research
Critical evaluation of the expression of gastrin-releasing peptide in dorsal root ganglia and spinal cord
There are substantial disagreements about the expression of gastrin-releasing peptide (GRP) in sensory neurons and whether GRP antibody cross-reacts with substance P (SP). These concerns necessitate a critical revaluation of GRP expression using additional approaches. Here, we show that a widely used GRP antibody specifically recognizes GRP but not SP. In the spinal cord of mice lacking SP (Tac1 KO), the expression of not only GRP but also other peptides, notably neuropeptide Y (NPY), is significantly diminished. We detected Grp mRNA in dorsal root ganglias using reverse transcription polymerase chain reaction, in situ hyb...
Source: Molecular Pain - April 10, 2016 Category: Molecular Biology Authors: Barry, D. M., Li, H., Liu, X.-Y., Shen, K.-F., Liu, X.-T., Wu, Z.-Y., Munanairi, A., Chen, X.-J., Yin, J., Sun, Y.-G., Li, Y.-Q., Chen, Z.-F. Tags: Research Article Source Type: research
Resveratrol attenuates inflammation-induced hyperexcitability of trigeminal spinal nucleus caudalis neurons associated with hyperalgesia in rats
Conclusion
These results suggest that chronic administration of resveratrol attenuates inflammation-induced mechanical inflammatory hyperalgesia and that this effect is due primarily to the suppression of spinal trigeminal nucleus caudalis wide dynamic range neuron hyperexcitability via inhibition of both peripheral and central cyclooxygenase-2 cascade signaling pathways. These findings support the idea of resveratrol as a potential complementary and alternative medicine for the treatment of trigeminal inflammatory hyperalgesia without side effects. (Source: Molecular Pain)
Source: Molecular Pain - April 10, 2016 Category: Molecular Biology Authors: Sekiguchi, K., Takehana, S., Shibuya, E., Matsuzawa, N., Hidaka, S., Kanai, Y., Inoue, M., Kubota, Y., Shimazu, Y., Takeda, M. Tags: Research Article Source Type: research
Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain
Conclusions
We provide evidence for modulation of nociceptive processing in a chronic knee osteoarthritis pain model with stronger brain activation and alteration of brain networks induced by the pro-nociceptive stimulus. We also report a shift to a medial pain activation pattern following stimulation of the hyperalgesic hindpaw. Taken together, our data support altered neural pain processing as a result of peripheral and central pain sensitization in this model. (Source: Molecular Pain)
Source: Molecular Pain - April 10, 2016 Category: Molecular Biology Authors: Abaei, M., Sagar, D. R., Stockley, E. G., Spicer, C. H., Prior, M., Chapman, V., Auer, D. P. Tags: Research Article Source Type: research
CREB-regulated transcription coactivator 1 enhances CREB-dependent gene expression in spinal cord to maintain the bone cancer pain in mice
Conclusions
Upregulation of CRTC1 enhancing CREB-dependent gene transcription in spinal cord may play an important role in bone cancer pain. Inhibition of spinal CRTC1 expression reduced bone cancer pain. Interruption to the positive feedback circuit between CREB/CRTC1 and its targets may contribute to the analgesic effects. These findings may provide further insight into the mechanisms and treatment of bone cancer pain. (Source: Molecular Pain)
Source: Molecular Pain - April 7, 2016 Category: Molecular Biology Authors: Liang, Y., Liu, Y., Hou, B., Zhang, W., Liu, M., Sun, Y.-E., Ma, Z., Gu, X. Tags: Research Article Source Type: research
Synthesis and characterization of a disubstituted piperazine derivative with T-type channel blocking action and analgesic properties
Conclusions
Altogether, our data identify a novel T-type calcium channel blocker with tight structure activity relationship (SAR) and relevant in vivo efficacy in inflammatory pain conditions. (Source: Molecular Pain)
Source: Molecular Pain - April 5, 2016 Category: Molecular Biology Authors: Pudukulatham, Z., Zhang, F.-X., Gadotti, V. M., MDahoma, S., Swami, P., Tamboli, Y., Zamponi, G. W. Tags: Research Article Source Type: research
Stable, synthetic analogs of diadenosine tetraphosphate inhibit rat and human P2X3 receptors and inflammatory pain
Conclusions
Stable, synthetic Ap4A analogs (AppNHppA and AppCH2ppA) being weak partial agonist provoke potent high-affinity desensitization-mediated inhibition of homomeric P2X3Rs at low concentrations. Therefore, both analogs demonstrate clear potential as potent analgesic agents for use in the management of chronic pain associated with heightened P2X3R activation. (Source: Molecular Pain)
Source: Molecular Pain - March 28, 2016 Category: Molecular Biology Authors: Viatchenko-Karpinski, V., Novosolova, N., Ishchenko, Y., Azhar, M. A., Wright, M., Tsintsadze, V., Kamal, A., Burnashev, N., Miller, A. D., Voitenko, N., Giniatullin, R., Lozovaya, N. Tags: Original Article Source Type: research
The antiallodynic action of pregabalin in neuropathic pain is independent from the opioid system
Conclusions
We demonstrate that neither acute nor long-term antiallodynic effect of pregabalin in a context of neuropathic pain is mediated by the endogenous opioid system, which differs from opioid treatment of pain and antidepressant treatment of neuropathic pain. Our data are also supportive of an impact of gabapentinoid treatment on the neuroimmune aspect of neuropathic pain. (Source: Molecular Pain)
Source: Molecular Pain - March 28, 2016 Category: Molecular Biology Authors: Kremer, M., Yalcin, I., Nexon, L., Wurtz, X., Ceredig, R. A., Daniel, D., Hawkes, R. A., Salvat, E., Barrot, M. Tags: Research Article Source Type: research
Characterization of cutaneous and articular sensory neurons
Conclusion
This work makes a detailed characterization of cutaneous and articular sensory neurons and highlights the importance of making recordings from identified neuronal populations: sensory neurons innervating different tissues have subtly different properties, possibly reflecting different functions. (Source: Molecular Pain)
Source: Molecular Pain - March 14, 2016 Category: Molecular Biology Authors: da Silva Serra, I., Husson, Z., Bartlett, J. D., Smith, E. S. J. Tags: Research Article Source Type: research
Dorsal root ganglion transcriptome analysis following peripheral nerve injury in mice
Conclusion
Our findings suggest that next generation RNA sequencing can be used as a promising approach to analyze the changes of whole transcriptomes in dorsal root ganglia following nerve injury and to possibly identify new targets for prevention and treatment of neuropathic pain. (Source: Molecular Pain)
Source: Molecular Pain - March 10, 2016 Category: Molecular Biology Authors: Wu, S., Marie Lutz, B., Miao, X., Liang, L., Mo, K., Chang, Y.-J., Du, P., Soteropoulos, P., Tian, B., Kaufman, A. G., Bekker, A., Hu, Y., Tao, Y.-X. Tags: Original Article Source Type: research
Involvement of NIPSNAP1, a neuropeptide nocistatin-interacting protein, in inflammatory pain
Conclusions
These results suggest that changes in NIPSNAP1 expression may contribute to the pathogenesis of inflammatory pain. (Source: Molecular Pain)
Source: Molecular Pain - March 9, 2016 Category: Molecular Biology Authors: Okamoto, K., Ohashi, M., Ohno, K., Takeuchi, A., Matsuoka, E., Fujisato, K., Minami, T., Ito, S., Okuda-Ashitaka, E. Tags: Original Article Source Type: research
Dietary linoleic acid-induced alterations in pro- and anti-nociceptive lipid autacoids: Implications for idiopathic pain syndromes?
Conclusions
The present findings provide biochemical support for the hypothesis that the high linoleic acid content of modern industrialized diets may create a biochemical susceptibility to develop chronic pain. Dietary linoleic acid lowering should be further investigated as part of an integrative strategy for the prevention and management of idiopathic pain syndromes. (Source: Molecular Pain)
Source: Molecular Pain - March 9, 2016 Category: Molecular Biology Authors: Ramsden, C. E., Ringel, A., Majchrzak-Hong, S. F., Yang, J., Blanchard, H., Zamora, D., Loewke, J. D., Rapoport, S. I., Hibbeln, J. R., Davis, J. M., Hammock, B. D., Taha, A. Y. Tags: Research Article Source Type: research
