Epidural optogenetics for controlled analgesia
Conclusion
Epidural optogenetics provides a robust and powerful solution for activation of both excitatory and inhibitory opsins in sensory processing pathways. Our results demonstrate the potential of spinal optogenetics to modulate sensory behavior and produce analgesia in freely behaving animals. (Source: Molecular Pain)
Source: Molecular Pain - March 8, 2016 Category: Molecular Biology Authors: Bonin, R. P., Wang, F., Desrochers-Couture, M., Gasecka, A., Boulanger, M.-E., Cote, D. C., De Koninck, Y. Tags: Original Article Source Type: research
Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain
Conclusion
This study demonstrates the crosstalk between astrocytic CXCL12 and microglial CXCR4 in the pathogenesis of neuropathic pain using pSNL and CPIP models. Our results offer insights for the future research on CXCL12/CXCR4 axis and neuropathic pain therapy. (Source: Molecular Pain)
Source: Molecular Pain - March 7, 2016 Category: Molecular Biology Authors: Luo, X., Tai, W. L., Sun, L., Pan, Z., Xia, Z., Chung, S. K., Cheung, C. W. Tags: Original Article Source Type: research
Connexin 43 contributes to ectopic orofacial pain following inferior alveolar nerve injury
Conclusions
These findings indicate that the propagation of satellite glial cell activation throughout the trigeminal ganglion via gap junctions, which are composed of connexin 43, plays a pivotal role in ectopic mechanical hypersensitivity in whisker pad skin following inferior alveolar nerve injury. (Source: Molecular Pain)
Source: Molecular Pain - March 7, 2016 Category: Molecular Biology Authors: Kaji, K., Shinoda, M., Honda, K., Unno, S., Shimizu, N., Iwata, K. Tags: Research Article Source Type: research
Regulation of transient receptor potential vanilloid 1 expression in trigeminal ganglion neurons via methyl-CpG binding protein 2 signaling contributes tongue heat sensitivity and inflammatory hyperalgesia in mice
Conclusions
These findings indicate that tongue heat sensitivity and hypersensitivity are dependent on the expression of transient receptor potential vanilloid 1 which is regulated via MeCP2 signaling in trigeminal ganglion neurons innervating the tongue. (Source: Molecular Pain)
Source: Molecular Pain - March 7, 2016 Category: Molecular Biology Authors: Suzuki, A., Shinoda, M., Honda, K., Shirakawa, T., Iwata, K. Tags: Research Article Source Type: research
A quantitative study of neurochemically defined excitatory interneuron populations in laminae I-III of the mouse spinal cord
Conclusions
These results suggest that cells expressing neurotensin, NKB or GRP form largely non-overlapping sets that are likely to correspond to functional populations. In contrast, SST is widely expressed by excitatory interneurons that are likely to be functionally heterogeneous. (Source: Molecular Pain)
Source: Molecular Pain - March 7, 2016 Category: Molecular Biology Authors: Gutierrez-Mecinas, M., Furuta, T., Watanabe, M., Todd, A. J. Tags: Original Article Source Type: research
Functional characterization of a mouse model for central post-stroke pain
Conclusions
These results suggest that the evoked hypersensitivity observed in central post-stroke pain is causally linked to on-going neuronal activity in the lateral thalamus. (Source: Molecular Pain)
Source: Molecular Pain - March 7, 2016 Category: Molecular Biology Authors: Gritsch, S., Bali, K. K., Kuner, R., Vardeh, D. Tags: Original Article Source Type: research
Improvements in impaired GABA and GAD65/67 production in the spinal dorsal horn contribute to exercise-induced hypoalgesia in a mouse model of neuropathic pain
Conclusions
Treadmill running prevented PSL-induced reductions in GAD65/67 production, and, thus, GABA levels may be retained in interneurons and neuropils in the superficial dorsal horn. Therefore, improvements in impaired GABAergic inhibition may be involved in exercise-induced hypoalgesia. (Source: Molecular Pain)
Source: Molecular Pain - March 6, 2016 Category: Molecular Biology Authors: Kami, K., Taguchi, MS, S., Tajima, F., Senba, E. Tags: Original Article Source Type: research
Differences in electrophysiological properties of functionally identified nociceptive sensory neurons in an animal model of cancer-induced bone pain
Conclusions
This work represents a significant technical and conceptual advance in the study of peripheral nociceptor functions in the development of cancer-induced bone pain. This is the first study to report that changes in sensitivity and excitability of dorsal root ganglion primary afferents directly correspond to mechanical allodynia and hyperalgesia behaviours following prostate cancer cell injection into the femur of rats. Furthermore, our unique combination of techniques has allowed us to follow, in a single neuron, mechanical pain-related behaviours, electrophysiological changes in action potential properties, and...
Source: Molecular Pain - February 29, 2016 Category: Molecular Biology Authors: Zhu, Y. F., Ungard, R., Seidlitz, E., Zacal, N., Huizinga, J., Henry, J. L., Singh, G. Tags: Original Article Source Type: research
Spinal nociceptive transmission by mechanical stimulation of bone marrow
Conclusions
The results suggest that mechanical stimulation to bone marrow produces nociception, concomitantly producing its referred pain in the corresponding skin fields. These mechanisms might contribute to pain caused by skeletal diseases. (Source: Molecular Pain)
Source: Molecular Pain - February 29, 2016 Category: Molecular Biology Authors: Ishida, T., Tanaka, S., Sekiguchi, T., Sugiyama, D., Kawamata, M. Tags: Original Article Source Type: research
Functional and structural characterization of axonal opioid receptors as targets for analgesia
Conclusion
MOPs are present and functional in the axonal membrane from naïve animals. Hypertonic saline acutely decreases ligand-induced internalization of MOP and thereby might improve MOP function. Further studies should explore potential clinical applications of opioids together with enhancers for regional analgesia. (Source: Molecular Pain)
Source: Molecular Pain - February 29, 2016 Category: Molecular Biology Authors: Mambretti, E. M., Kistner, K., Mayer, S., Massotte, D., Kieffer, B. L., Hoffmann, C., Reeh, P. W., Brack, A., Asan, E., Rittner, H. L. Tags: Original Article Source Type: research
Impairments of the primary afferent nerves in a rat model of diabetic visceral hyposensitivity
Conclusions:
These observations revealed the distinctive feature of colonic neuropathy in short-term diabetic rats that is characterized by a diminished sensory innervation and a blunted mechanosensitivity of the remnant sensory nerves. (Source: Molecular Pain)
Source: Molecular Pain - December 10, 2015 Category: Molecular Biology Authors: Li DongXizi LiangBiying SunXiaowei DingHongxiu HanWeifang RongGuohua Zhang Source Type: research
Short-term pre- and post-operative stress prolongs incision-induced pain hypersensitivity without changing basal pain perception
Conclusion:
Our results indicate that short-term stress during the pre- or post-operative period delays postoperative pain recovery although it does not affect basal pain perception. Prevention of short-term stress may facilitate patients’ recovery from postoperative pain. (Source: Molecular Pain)
Source: Molecular Pain - December 2, 2015 Category: Molecular Biology Authors: Jing CaoPo-Kai WangVinod TiwariLingli LiangBrianna LutzKun-Ruey ShiehWei-Dong ZangAndrew KaufmanAlex BekkerXiao-Qun GaoYuan-Xiang Tao Source Type: research
The role of Na v 1.9 channel in the development of neuropathic orofacial pain associated with trigeminal neuralgia
Conclusions:
These results demonstrate that Na
v
1.9 channels play a critical role in the development of orofacial neuropathic pain. New routes for the treatment of orofacial neuropathic pain focussing on regulation of the voltage-gated Na
v
1.9 sodium channel activity should be investigated. (Source: Molecular Pain)
Source: Molecular Pain - November 25, 2015 Category: Molecular Biology Authors: Ana LuizOlga KopachSonia Santana-VarelaJohn Wood Source Type: research
The effect of kinin B1 receptor on chronic itching sensitization
Conclusion:
Our data provide evidence that B1R facilitates the chronic itching sensation related to keratinocytes in a DCP-treated chronic inflammation experimental model. (Source: Molecular Pain)
Source: Molecular Pain - November 14, 2015 Category: Molecular Biology Authors: Yuying LiuJianhua LiuMengran LiSailin DaiJiexian LiangWenjin Ji Source Type: research
Brain natriuretic peptide constitutively downregulates P2X3 receptors by controlling their phosphorylation state and membrane localization
Conclusions:
We demonstrated that in mouse trigeminal neurons endogenous BNP acts on NPR-A receptors to determine constitutive depression of P2X3 receptor function. Tonic inhibition of P2X3 receptor activity by BNP/NPR-A/PKG pathways occurs via two distinct mechanisms: P2X3 serine phosphorylation and receptor redistribution to non-raft membrane compartments. This novel mechanism of receptor control might be a target for future studies aiming at decreasing dysregulated P2X3 receptor activity in chronic pain. (Source: Molecular Pain)
Source: Molecular Pain - November 14, 2015 Category: Molecular Biology Authors: Anna MarchenkovaSandra VilottiElsa FabbrettiAndrea Nistri Source Type: research
