Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain

Conclusion This study demonstrates the crosstalk between astrocytic CXCL12 and microglial CXCR4 in the pathogenesis of neuropathic pain using pSNL and CPIP models. Our results offer insights for the future research on CXCL12/CXCR4 axis and neuropathic pain therapy.

http://mpx.sagepub.com/cgi/content/abstract/12/0/1744806916636385?rss=1

Source: Molecular Pain - March 7, 2016 Category: Molecular Biology Authors: Luo, X., Tai, W. L., Sun, L., Pan, Z., Xia, Z., Chung, S. K., Cheung, C. W. Tags: Original Article Source Type: research