Functional and structural characterization of axonal opioid receptors as targets for analgesia

Conclusion MOPs are present and functional in the axonal membrane from naïve animals. Hypertonic saline acutely decreases ligand-induced internalization of MOP and thereby might improve MOP function. Further studies should explore potential clinical applications of opioids together with enhancers for regional analgesia.

http://mpx.sagepub.com/cgi/content/abstract/12/0/1744806916628734?rss=1

Source: Molecular Pain - February 29, 2016 Category: Molecular Biology Authors: Mambretti, E. M., Kistner, K., Mayer, S., Massotte, D., Kieffer, B. L., Hoffmann, C., Reeh, P. W., Brack, A., Asan, E., Rittner, H. L. Tags: Original Article Source Type: research