Analgesic effects of adenylyl cyclase inhibitor NB001 on bone cancer pain in a mouse model
Conclusions
NB001 may serve as a novel analgesic to treat bone cancer pain. Its analgesic effect is at least partially due to the inhibition of AC1 in anterior cingulate cortex. (Source: Molecular Pain)
Source: Molecular Pain - September 8, 2016 Category: Molecular Biology Authors: Kang, W.-b., Yang, Q., Guo, Y.-y., Wang, L., Wang, D.-s., Cheng, Q., Li, X.-m., Tang, J., Zhao, J.-n., Liu, G., Zhuo, M., Zhao, M.-g. Tags: Research Article Source Type: research
Downregulation of miR-219 enhances brain-derived neurotrophic factor production in mouse dorsal root ganglia to mediate morphine analgesic tolerance by upregulating CaMKII{gamma}
Conclusions
These results demonstrate that miR-219 contributes to the development of chronic tolerance to morphine analgesia in mouse dorsal root ganglia by targeting CaMKII and enhancing CaMKII-dependent brain-derived neurotrophic factor expression. (Source: Molecular Pain)
Source: Molecular Pain - September 4, 2016 Category: Molecular Biology Authors: Hu, X.-M., Cao, S.-B., Zhang, H.-L., Lyu, D.-M., Chen, L.-P., Xu, H., Pan, Z.-Q., Shen, W. Tags: Research Article Source Type: research
Repeated activation of delta opioid receptors counteracts nerve injury-induced TNF-{alpha} up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opioid receptors-mediated antiallodinic effect
Despite mu opioid receptor agonists are the cornerstones of moderate-to-severe acute pain treatment, their effectiveness in chronic pain conditions is controversial. In contrast to mu opioid receptor agonists, a number of studies have reported the effectiveness of delta opioid receptor agonists on neuropathic pain strengthening the idea that delta opioid receptors gain importance when chronic pain develops. Among other effects, it has been shown that delta opioid receptor activation in optic nerve astrocytes inhibits tumor necrosis factor-α-mediated inflammation in response to severe hypoxia. Considering the involvem...
Source: Molecular Pain - September 1, 2016 Category: Molecular Biology Authors: Vicario, N., Parenti, R., Arico, G., Turnaturi, R., Scoto, G. M., Chiechio, S., Parenti, C. Tags: Short Report Source Type: research
BDNF signaling contributes to oral cancer pain in a preclinical orthotopic rodent model
The majority of patients with oral cancer report intense pain that is only partially managed by current analgesics. Thus, there is a strong need to study mechanisms as well as develop novel analgesics for oral cancer pain. Current study employed an orthotopic tongue cancer model with molecular and non-reflexive behavioral assays to determine possible mechanisms of oral cancer pain. Human oral squamous cell carcinoma cells line, HSC2, was injected into the tongue of male athymic mice and tumor growth was observed by day 6. Immunohistological analyses revealed a well-differentiated tumor with a localized immune response and ...
Source: Molecular Pain - September 1, 2016 Category: Molecular Biology Authors: Chodroff, L., Bendele, M., Valenzuela, V., Henry, M., Ruparel, S. Tags: Research Article Source Type: research
Repeated activation of delta opiod receptors counteracts nerve injury-induced TNF-{alpha} up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opiod receptors-mediated antiallodinic effect
(Source: Molecular Pain)
Source: Molecular Pain - September 1, 2016 Category: Molecular Biology Authors: Vicario, N., Parenti, R., Arico', G., Turnaturi, R., Scoto, G. M., Chiechio, S., Parenti, C. Tags: Articles Source Type: research
EXPRESS: BDNF Signaling Contributes to Oral Cancer Pain in a Preclinical Orthotopic Rodent Model
(Source: Molecular Pain)
Source: Molecular Pain - September 1, 2016 Category: Molecular Biology Authors: Chodroff, L., Bendele, M., Valenzuela, V., Henry, M., Ruparel, S. Tags: Articles Source Type: research
Ganglioside GM3 synthase depletion reverses neuropathic pain and small fiber neuropathy in diet-induced diabetic mice
Conclusions
These studies establish ganglioside GM3 as a new candidate responsible for neuropathic pain and small fiber neuropathy in diabetes. Moreover, these observations indicate that systemic or topically applied interventions aimed at depleting GM3 may improve both the painful neuropathy and the wound healing impairment in diabetes by protecting against nerve end terminal degeneration, providing a disease-modifying approach to this common, currently intractable medical issue. (Source: Molecular Pain)
Source: Molecular Pain - September 1, 2016 Category: Molecular Biology Authors: Menichella, D. M., Jayaraj, N. D., Wilson, H. M., Ren, D., Flood, K., Wang, X.-Q., Shum, A., Miller, R. J., Paller, A. S. Tags: Research Article Source Type: research
A SCN10A SNP biases human pain sensitivity
Conclusions:
At the association and mechanistic levels, the SCN10A single nucleotide polymorphism rs6795970 biases human pain sensitivity. (Source: Molecular Pain)
Source: Molecular Pain - September 1, 2016 Category: Molecular Biology Authors: Duan, G., Han, C., Wang, Q., Guo, S., Zhang, Y., Ying, Y., Huang, P., Zhang, L., Macala, L., Shah, P., Zhang, M., Li, N., Dib-Hajj, S. D., Waxman, S. G., Zhang, X. Tags: Research Article Source Type: research
Changes in synaptic transmission of substantia gelatinosa neurons after spinal cord hemisection revealed by analysis using in vivo patch-clamp recording
Conclusions
These suggest that substantia gelatinosa neurons receive tonic inhibition by spinal inhibitory interneurons which generate persistent action potentials. Spinal hemisection results in hyperexcitation of substantia gelatinosa neurons at least in part by eliminating the tonic descending control of spinal inhibitory interneurons from supraspinal levels. (Source: Molecular Pain)
Source: Molecular Pain - August 27, 2016 Category: Molecular Biology Authors: Kozuka, Y., Kawamata, M., Furue, H., Ishida, T., Tanaka, S., Namiki, A., Yamakage, M. Tags: Research Article Source Type: research
Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target
Burn injury is a cause of significant mortality and morbidity worldwide and is frequently associated with severe and long-lasting pain that remains difficult to manage throughout recovery. We characterised a mouse model of burn-induced pain using pharmacological and transcriptomic approaches. Mechanical allodynia elicited by burn injury was partially reversed by meloxicam (5 mg/kg), gabapentin (100 mg/kg) and oxycodone (3 and 10 mg/kg), while thermal allodynia and gait abnormalities were only significantly improved by amitriptyline (3 mg/kg) and oxycodone (10 mg/kg). The need for relatively high opioid doses to elicit anal...
Source: Molecular Pain - August 27, 2016 Category: Molecular Biology Authors: Yin, K., Deuis, J. R., Lewis, R. J., Vetter, I. Tags: Research Article Source Type: research
Dopaminergic inhibition by G9a/Glp complex on tyrosine hydroxylase in nerve injury-induced hypersensitivity
The neural balance between facilitation and inhibition determines the final tendency of central sensitization. Nerve injury-induced hypersensitivity was considered as the results from the enhanced ascending facilitation and the diminished descending inhibition. The role of dopaminergic transmission in the descending inhibition has been well documented, but its underlying molecular mechanisms are unclear. Previous studies demonstrated that the lysine dimethyltransferase G9a/G9a-like protein (Glp) complex plays a critical role in cocaine-induced central plasticity, and given cocaine’s role in the nerve system is relied...
Source: Molecular Pain - August 23, 2016 Category: Molecular Biology Authors: Wang, N., Shen, X., Bao, S., Feng, S.-W., Wang, W., Liu, Y., Wang, Y., Wang, X., Guo, X., Shen, R., Wu, H., Lei, L., Xu, S., Wang, F. Tags: Research Article Source Type: research
The stress protein heat shock cognate 70 (Hsc70) inhibits the Transient Receptor Potential Vanilloid type 1 (TRPV1) channel
Conclusions
Our work identified Hsc70 and its ATPase activity as a central cofactor of TRPV1 channel function and points to the role of this stress protein in pain associated with neurodegenerative and/or metabolic disorders, including aging. (Source: Molecular Pain)
Source: Molecular Pain - August 23, 2016 Category: Molecular Biology Authors: Iftinca, M., Flynn, R., Basso, L., Melo, H., Aboushousha, R., Taylor, L., Altier, C. Tags: Research Article Source Type: research
Increased expression of Trpv1 in peripheral terminals mediates thermal nociception in Fabry disease mouse model
Fabry disease is a X-linked lysosomal storage disorder caused by deficient function of the alpha-galactosidase A (α-GalA) enzyme. α-GalA deficiency leads to multisystemic clinical manifestations caused by the preferential accumulation of globotriaosylceramide (Gb3) in the endothelium and vascular smooth muscles. A hallmark symptom of Fabry disease patients is neuropathic pain that appears in the early stage of the disease as a result of peripheral small fiber damage. The α-GalA gene null mouse model (α-GalA(–/0)) has provided molecular evidence for the molecular alterations in small type-C noc...
Source: Molecular Pain - August 15, 2016 Category: Molecular Biology Authors: Lakoma, J., Rimondini, R., Ferrer Montiel, A., Donadio, V., Liguori, R., Caprini, M. Tags: Research Article Source Type: research
High levels of endogenous lipid mediators (N-acylethanolamines) in women with chronic widespread pain during acute tissue trauma
Although chronic widespread musculoskeletal pain is a significant health problem, the molecular mechanisms involved in developing and maintaining chronic widespread musculoskeletal pain are poorly understood. Central sensitization mechanisms maintained by stimuli from peripheral tissues such as muscle have been suggested. Lipid mediators with anti-inflammatory characteristics such as endogenous ligands of peroxisome proliferator activating receptor-α, oleoylethanolamide, and palmitoylethanolamide are suggested to regulate nociceptive transmission from peripheral locations on route towards the central nervous system. ...
Source: Molecular Pain - August 15, 2016 Category: Molecular Biology Authors: Stensson, N., Ghafouri, B., Ghafouri, N., Gerdle, B. Tags: Research Article Source Type: research
Diminished supraspinal pain modulation in patients with mild traumatic brain injury
Conclusions
In short, the current study demonstrates that patients with mild traumatic brain injury and headaches appear to have an altered state of supraspinal modulatory and affective functions related to pain perception. (Source: Molecular Pain)
Source: Molecular Pain - August 15, 2016 Category: Molecular Biology Authors: Leung, A., Shukla, S., Yang, E., Canlas, B., Kadokana, M., Heald, J., Davani, A., Song, D., Lin, L., Polston, G., Tsai, A., Lee, R. Tags: Research Article Source Type: research
