Differential modulation of nociceptive versus non-nociceptive synapses by endocannabinoids
Conclusions:
These findings show that endocannabinoids can differentially modulate nociceptive vs. non-nociceptive synapses and that GABAergic regulation of these synapses plays an important role in determining whether endocannabinoids have a potentiating or depressing effect. (Source: Molecular Pain)
Source: Molecular Pain - June 1, 2013 Category: Molecular Biology Authors: Alexandra HigginsSharleen YuanYanqing WangBrian Burrell Source Type: research
Voluntary movements as a possible non-reflexive pain assay
Conclusions:
These results suggest that parameters of voluntary movement, such as, number of rearing and total distance moved, are effective indicators of pain intensity for many types of pain and that they can be used to evaluate degree of pain perception. (Source: Molecular Pain)
Source: Molecular Pain - May 20, 2013 Category: Molecular Biology Authors: Hawon ChoYongwoo JangByeongjun LeeHyeyoun ChunJooyoung JungSung KimSun HwangUhtaek Oh Source Type: research
TGF-ß1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells
Conclusions:
Cdk5 and p35 are expressed in a murine odontoblast-enriched primary preparation of cells from teeth. Cdk5 is also functionally active in odontoblast-like MDPC-23 cells. TGF-β1 sensitizes TRPV1 through Cdk5 signaling in MDPC-23 cells, suggesting the direct involvement of odontoblasts and Cdk5 in dental nociceptive pain transduction. (Source: Molecular Pain)
Source: Molecular Pain - May 13, 2013 Category: Molecular Biology Authors: Elias UtrerasMichaela ProchazkovaAnita TerseJacklyn GrossJason KellerMichael IadarolaAshok Kulkarni Source Type: research
TGF-beta1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells
Conclusions:
Cdk5 and p35 are expressed in a murine odontoblast-enriched primary preparation of cells from teeth. Cdk5 is also functionally active in odontoblast-like MDPC-23 cells. TGF-beta1 sensitizes TRPV1 through Cdk5 signaling in MDPC-23 cells, suggesting the direct involvement of odontoblasts and Cdk5 in dental nociceptive pain transduction. (Source: Molecular Pain)
Source: Molecular Pain - May 13, 2013 Category: Molecular Biology Authors: Elias UtrerasMichaela ProchazkovaAnita TerseJacklyn GrossJason KellerMichael IadarolaAshok Kulkarni Source Type: research
Phospholipase C-related but catalytically inactive protein modulates pain behavior in a neuropathic pain model in mice
Conclusions:
Suppressed expression of PRIPs induces an elevated expression of KCC2 in the spinal cord, resulting in inhibition of nociception and amelioration of neuropathic pain in DKO mice. (Source: Molecular Pain)
Source: Molecular Pain - May 2, 2013 Category: Molecular Biology Authors: Tomoya KitayamaKatsuya MoritaRizia SultanaNami KikushigeKeisuke MgitaShinya UenoMasato HirataTakashi Kanematsu Source Type: research
Sodium-calcium exchangers in rat trigeminal ganglion neurons
Conclusions:
Our results suggest that NCXs in TG neurons play an important role in regulating Ca2+-homeostasis and somatosensory information processing by functionally coupling with voltage-dependent Na+ channels. (Source: Molecular Pain)
Source: Molecular Pain - April 29, 2013 Category: Molecular Biology Authors: Hidetaka KurodaUbaidus SobhanMasaki SatoMaki TsumuraTatsuya IchinoheMasakazu TazakiYoshiyuki Shibukawa Source Type: research
Peripheral nerve injury is accompanied by chronic transcriptome-wide changes in the mouse prefrontal cortex
Conclusions:
This study used an unbiased approach to document long-term alterations in gene expression in the brain following peripheral nerve injury. We propose that these changes are maintained as a memory of an insult that is temporally and spatially distant from the initial injury. (Source: Molecular Pain)
Source: Molecular Pain - April 18, 2013 Category: Molecular Biology Authors: Sebastian AlvaradoMaral TajerianMagali MillecampsMathew SudermanLaura StoneMoshe Szyf Source Type: research
Gender, variation in opioid receptor genes and sensitivity to experimental pain
Conclusion:
This is a preliminary and hypothesis generating study due to the relatively small study size. However, significant association between the opioid receptor genes and experimental pain sensitivity supports the influence of genetic variability in pain perception. These findings may be used to generate hypotheses for testing in larger clinical trials of patients with painful conditions. (Source: Molecular Pain)
Source: Molecular Pain - April 9, 2013 Category: Molecular Biology Authors: Hiroe SatoJoanne DroneyJoy RossAnne OlesenCamilla StaahlTrine AndresenRuth BranfordJulia RileyLars Arendt-NielsenAsbjørn Drewes Source Type: research
Chronic pain after lower abdominal surgery: do catechol-O-methyl transferase/opioid receptor ¿-1 polymorphisms contribute?
Conclusions:
OPRM1 genotype influences CPP following lower abdominal surgery. COMT didn't affect CPP, suggesting its potential modality-specific effects on human pain. (Source: Molecular Pain)
Source: Molecular Pain - April 8, 2013 Category: Molecular Biology Authors: Yuri KolesnikovBoris GabovitsAriel LevinAndres VeskeLi QinFeng DaiInna Belfer Source Type: research
Electroacupuncture improves thermal and mechanical sensitivities in a rat model of postherpetic neuralgia
Conclusions:
EA treatment improves thermal perception by recovering TRPV1-positive sensory neurons and nerve terminals damaged by RTX. EA Also reduces RTX-induced tactile allodynia by attenuating the damage of myelinated afferent nerves and their abnormal sprouting into the spinal lamina II. Our study provides new information about the mechanisms of the therapeutic actions of EA in the treatment of PHN. (Source: Molecular Pain)
Source: Molecular Pain - April 3, 2013 Category: Molecular Biology Authors: Cai-hua WuZheng-tao LvYin ZhaoYan GaoJia-qing LiFang GaoXian-fang MengBo TianJing ShiHui-lin PanMan Li Source Type: research
Role of voltage gated Ca2+ channels in rat visceral hypersensitivity change induced by 2,4,6-trinitrobenzene sulfonic acid
Conclusion:
Cav1.2 and Cav2.3 in colonic primary sensory neurons play an important role in visceral inflammatory hyperalgesia, which maybe the potential therapeutic targets. (Source: Molecular Pain)
Source: Molecular Pain - March 28, 2013 Category: Molecular Biology Authors: Aihua QianDandan SongYong LiXinqiu LiuDong TangWeiyan YaoYaozong Yuan Source Type: research
Enhancement by interleukin-1beta of AMPA and NMDA receptor-mediated currents in adult rat spinal superficial dorsal horn neurons
Conclusions:
IL-1β enhances AMPA and NMDA responses in SG neurons through IL-1R activation; the former but not latter action is reversible and due to an increase in neuronal activity in a manner dependent on extracellular Ca2+ and minocycline. It is suggested that AMPA and NMDA receptors are positively modulated by IL-1β in a manner different from each other; the former but not latter is mediated by a neurotransmitter released as a result of an increase in neuronal activity. Since IL-1β contributes to nociceptive behavior induced by peripheral nerve or tissue injury, the present findings also reveal an important cellula...
Source: Molecular Pain - March 28, 2013 Category: Molecular Biology Authors: Tao LiuChang-Yu JiangTsugumi FujitaShi-Wen LuoEiichi Kumamoto Source Type: research
Preclinical studies of low back pain
Chronic low back pain is a major cause of disability and health care costs. Current treatments are inadequate for many patients. A number of preclinical models have been developed that attempt to mimic aspects of clinical conditions that contribute to low back pain. These involve application of nucleus pulposus material near the lumbar dorsal root ganglia (DRG), chronic compression of the DRG, or localized inflammation of the DRG. These models, which are primarily implemented in rats, have many common features including behavioral hypersensitivity of the hindpaw, enhanced excitability and spontaneous activity of sensory ne...
Source: Molecular Pain - March 28, 2013 Category: Molecular Biology Authors: Judith StrongWenrui XieFeguens BatailleJun-Ming Zhang Source Type: research
Proteomic and functional annotation analysis of injured peripheral nerves reveals ApoE as a protein upregulated by injury that is modulated by metformin treatment
Conclusions:
These proteomic findings support the hypothesis that PNI leads to a fundamental reorganization of gene expression within the injured nerve. Our data identify a key association of ApoE with PNI that is regulated by metformin treatment. We conclude from the known functions of ApoE in the nervous system that ApoE may be an intrinsic factor linked to nerve regeneration after PNI, an effect that is further enhanced by metformin treatment. (Source: Molecular Pain)
Source: Molecular Pain - March 26, 2013 Category: Molecular Biology Authors: Ohannes MelemedjianHussein YassineAdia ShyTheodore Price Source Type: research
Intervention of electroacupuncture on spinal p38 MAPK/ATF-2/VR-1 pathway in treating inflammatory pain induced by CFA in rats
Conclusions:
The present study indicates that inhibiting the activation of spinal p38 MAPK/ATF-2/VR-1 pathway may be one of the main mechanisms via central signal transduction pathway in the process of anti-inflammatory pain by EA in CFA rats. (Source: Molecular Pain)
Source: Molecular Pain - March 22, 2013 Category: Molecular Biology Authors: Jian-Qiao FangJun-Ying DuYi LiangJun-Fan Fang Source Type: research
