TGF-beta1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells

Conclusions: Cdk5 and p35 are expressed in a murine odontoblast-enriched primary preparation of cells from teeth. Cdk5 is also functionally active in odontoblast-like MDPC-23 cells. TGF-beta1 sensitizes TRPV1 through Cdk5 signaling in MDPC-23 cells, suggesting the direct involvement of odontoblasts and Cdk5 in dental nociceptive pain transduction.
Source: Molecular Pain - Category: Molecular Biology Authors: Source Type: research