Phospholipase C-related but catalytically inactive protein modulates pain behavior in a neuropathic pain model in mice

Conclusions:
Suppressed expression of PRIPs induces an elevated expression of KCC2 in the spinal cord, resulting in inhibition of nociception and amelioration of neuropathic pain in DKO mice.

Source: Molecular Pain - May 2, 2013 Category: Molecular Biology Authors: Tomoya KitayamaKatsuya MoritaRizia SultanaNami KikushigeKeisuke MgitaShinya UenoMasato HirataTakashi Kanematsu Source Type: research