MeCP2 plays an analgesic role in pain transmission through regulating CREB / miR-132 pathway
Conclusions:
Our study shows that MeCP2 plays an analgesic role in both acute pain transduction and chronic pain formation through regulating CREB-miR-132 pathway. This work provides a potential therapeutic target for neural pathologic pain, and also sheds new lights on the abnormal sensory mechanisms associated with autism spectrum orders. (Source: Molecular Pain)
Source: Molecular Pain - April 12, 2015 Category: Molecular Biology Authors: Ran ZhangMin HuangZhijuan CaoJieyu QiZilong QiuLi-Yang Chiang Source Type: research
Lack of evidence for ectopic sprouting of genetically labeled Aβ touch afferents in inflammatory and neuropathic trigeminal pain
Conclusions:
CreER-based labeling prior to injury precluded the issue of phenotypic changes of neurons after injury. Our results suggest that touch allodynia in chronic orofacial pain is unlikely caused by ectopic sprouting of Aβ trigeminal afferents. (Source: Molecular Pain)
Source: Molecular Pain - April 10, 2015 Category: Molecular Biology Authors: Yi ZhangYong ChenWolfgang LiedtkeFan Wang Source Type: research
Properties of sodium currents in neonatal and young adult mouse superficial dorsal horn neurons
Conclusions:
Our study suggests sodium channel expression changes markedly during early postnatal development in mouse SDH neurons. The methods employed in this study can now be applied to future investigations of spinal cord sodium channel plasticity in murine pain models. (Source: Molecular Pain)
Source: Molecular Pain - March 28, 2015 Category: Molecular Biology Authors: Melissa TadrosKristen FarrellBrett GrahamAlan BrichtaRobert Callister Source Type: research
Anxiolytic-like effects of translocator protein (TSPO) ligand ZBD-2 in an animal model of chronic pain
The activation of Translocator protein (18 kDa) (TSPO) has been demonstrated to mediate rapid anxiolytic efficacy in stress response and stress-related disorders. This protein is involved in the synthesis of endogenous neurosteroids that promote γ-aminobutyric acid (GABA)-mediated neurotransmission in the central neural system. However, little is known about the functions and the underlying mechanisms of TSPO in chronic pain-induced anxiety-like behaviors. The novel TSPO ligand N-benzyl-N-ethyl-2-(7,8-dihydro-7-benzyl-8-oxo-2-phenyl-9H-purin-9-yl) acetamide (ZBD-2) was used in the present study. We found that ZBD-2 (0.15...
Source: Molecular Pain - March 26, 2015 Category: Molecular Biology Authors: Dong-sheng WangZhen TianYan-yan GuoHong-liang GuoWen-bo KangShuo LiYa-ting DenXu-bo LiBing FengDan FengJian-ning ZhaoGang LiuMing-gao Zhao Source Type: research
N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans
Conclusions:
Our findings show for the first time that NAC inhibits nociceptive transmission in humans, and does the same in mice by activating mGlu2/3 receptors. These data lay the groundwork for investigating the therapeutic potential of NAC in patients with chronic pain. (Source: Molecular Pain)
Source: Molecular Pain - March 20, 2015 Category: Molecular Biology Authors: Andrea TruiniSerena PirosoErica PasqualeSerena NotartomasoGiulia Di StefanoRoberta LattanziGiuseppe BattagliaFerdinando NicolettiGiorgio Cruccu Source Type: research
Sensitization of P2X3 receptors by cystathionine β-synthetase mediates persistent pain hypersensitivity in a rat model of lumbar disc herniation
Lumbar disc herniation (LDH) is a major cause of discogenic low back pain and sciatica, but the underlying mechanisms remain largely unknown. Hydrogen sulfide (H2S) is becoming recognized for its involvement in a wide variety of processes including inflammation and nociception. The present study was designed to investigate the roles of the H2S signaling pathway in the regulation of expression and function of purinergic receptors (P2XRs) in dorsal root ganglion (DRG) neurons from rats with LDH. LDH was induced by implantation of autologous nucleus pulposus (NP), harvested from rat tail, in lumbar 5 and 6 spinal nerve roots....
Source: Molecular Pain - March 20, 2015 Category: Molecular Biology Authors: Qianliang WangHongyan ZhuKang ZouBo YuanYou-Lang ZhouXinghong JiangJun YanGuang-Yin Xu Source Type: research
Protease-activated receptors in the Achilles tendon–a potential explanation for the excessive pain signalling in tendinopathy
Conclusions:
This study describes the expression patterns of PARs in the mid-portion of the Achilles tendon, which can help explain the tissue changes and increased pain signalling seen in tendinopathies. These findings also show that in-vitro studies of the effects of these receptors are plausible and that PARs are a possible therapeutic target in the future treatment strategies of tendinopathy. (Source: Molecular Pain)
Source: Molecular Pain - March 17, 2015 Category: Molecular Biology Authors: Jens ChristensenHåkan AlfredsonGustav Andersson Source Type: research
Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain
Conclusions:
Overall, our findings provide proof of concept for a new class of analgesics that target T-type channel deubiquitination. (Source: Molecular Pain)
Source: Molecular Pain - March 14, 2015 Category: Molecular Biology Authors: Vinicius GadottiAgustin CaballeroN BergerClare GladdingLina ChenTom PfeiferGerald Zamponi Source Type: research
The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury
Conclusions:
Our data suggest that LTB4-BLT1 axis contributes not only to the peripheral inflammation but also to the neuronal activation in the spinal cord induced by intraplantar formalin injections. Thus, LTB4-BLT1 signaling is a potential target for therapeutic intervention of acute and persistent pain induced by tissue injury. (Source: Molecular Pain)
Source: Molecular Pain - March 12, 2015 Category: Molecular Biology Authors: Miho AsaharaNobuko ItoTakehiko YokomizoMotonao NakamuraTakao ShimizuYoshitsugu Yamada Source Type: research
The absence of the leukotriene B 4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury
Conclusions:
Our data suggest that LTB4-BLT1 axis contributes not only to the peripheral inflammation but also to the neuronal activation in the spinal cord induced by intraplantar formalin injections. Thus, LTB4-BLT1 signaling is a potential target for therapeutic intervention of acute and persistent pain induced by tissue injury. (Source: Molecular Pain)
Source: Molecular Pain - March 12, 2015 Category: Molecular Biology Authors: Miho AsaharaNobuko ItoTakehiko YokomizoMotonao NakamuraTakao ShimizuYoshitsugu Yamada Source Type: research
Paclitaxel induces acute pain via directly activating toll like receptor 4
In this study, we found that paclitaxel causes acute pain in rodents in a dose-dependent manner. The paclitaxel-induced acute pain occurs within 2 hrs after a single intravenous injection of paclitaxel. This is accompanied by low levels of paclitaxel penetrating into the cerebral spinal fluid and spinal dorsal horn. We demonstrated that a intrathecal injection of paclitaxel induces mechanical allodynia in a dose-dependent manner. Paclitaxel causes activation of toll like receptor 4 (TLR4) in the spinal dorsal horn and dorsal root ganglions. Through activating TLR4, paclitaxel increases glutamatergic synaptic activities an...
Source: Molecular Pain - March 11, 2015 Category: Molecular Biology Authors: Xisheng YanDylan MaixnerRuchi YadavMei GaoPei LiMichael BartlettHan-Rong Weng Source Type: research
Peripherally increased artemin is a key regulator of TRPA1/V1 expression in primary afferent neurons
Conclusions:
These data indicate the important roles of peripherally-derived artemin on the regulation of TRPV1/A1 in DRG neurons in pathological conditions such as inflammatory and neuropathic pain. (Source: Molecular Pain)
Source: Molecular Pain - March 8, 2015 Category: Molecular Biology Authors: Yasuko Ikeda-MiyagawaKimiko KobayashiHiroki YamanakaMasamichi OkuboShenglan WangYi DaiHideshi YagiMunetaka HiroseKoichi Noguchi Source Type: research
A [ 14 C]iodoantipyrine study of inter-regional correlations of neural substrates following central post-stroke pain in rats
Conclusions:
These results corroborate previous findings that the STT and thalamocingulate pathway are involved in the pathophysiological mechanisms of CPSP symptoms. The mPFC, amygdala, and periaqueductal gray emerged as having important correlations in pain processing in CPSP. The present data provide a basis for a neural correlation hypothesis of CPSP, with implications for CPSP treatment. (Source: Molecular Pain)
Source: Molecular Pain - March 8, 2015 Category: Molecular Biology Authors: Hsiang-Chin LuWei-Jen ChangYung-Hui KuanAndrew HuangBai Shyu Source Type: research
Alleviation of neuropathic pain by regulating T-type calcium channels in rat anterior cingulate cortex
Conclusions:
TCCs in the ACC may be contributing to the maintenance of neuropathic pain, and the neuropathic pain can be alleviated by inhibiting the neuronal activity of ACC through modulating the TCCs. (Source: Molecular Pain)
Source: Molecular Pain - March 6, 2015 Category: Molecular Biology Authors: Feng-Yan ShenZhi-Yu ChenWei ZhongLi-Qing MaChong ChenZhou-Jing YangWei-Lin XieYing-Wei Wang Source Type: research
Types of skin afferent fibers and spinal opioid receptors that contribute to touch-induced inhibition of heart rate changes evoked by noxious cutaneous heat stimulation
Conclusions:
Microcone touch induced greater responses of low-threshold mechanoreceptive A? and C afferent units than control touch. The antinociceptive effect of microcone touch was abolished by intrathecal injection of ?-opioid receptor antagonist. These results suggest that excitation of low-threshold mechanoreceptive A? and C afferents produces the release of endogenous ?-opioid ligands in the spinal cord, resulting in the inhibition of nociceptive transmission that contributes to somatocardiac reflexes. (Source: Molecular Pain)
Source: Molecular Pain - February 12, 2015 Category: Molecular Biology Authors: Nobuhiro WatanabeMathieu PichéHarumi Hotta Source Type: research
