Protease-activated receptors in the Achilles tendon–a potential explanation for the excessive pain signalling in tendinopathy

Conclusions: This study describes the expression patterns of PARs in the mid-portion of the Achilles tendon, which can help explain the tissue changes and increased pain signalling seen in tendinopathies. These findings also show that in-vitro studies of the effects of these receptors are plausible and that PARs are a possible therapeutic target in the future treatment strategies of tendinopathy.
Source: Molecular Pain - Category: Molecular Biology Authors: Source Type: research