N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans

Conclusions:
Our findings show for the first time that NAC inhibits nociceptive transmission in humans, and does the same in mice by activating mGlu2/3 receptors. These data lay the groundwork for investigating the therapeutic potential of NAC in patients with chronic pain.

Source: Molecular Pain - March 20, 2015 Category: Molecular Biology Authors: Andrea TruiniSerena PirosoErica PasqualeSerena NotartomasoGiulia Di StefanoRoberta LattanziGiuseppe BattagliaFerdinando NicolettiGiorgio Cruccu Source Type: research