MeCP2 plays an analgesic role in pain transmission through regulating CREB / miR-132 pathway

Conclusions: Our study shows that MeCP2 plays an analgesic role in both acute pain transduction and chronic pain formation through regulating CREB-miR-132 pathway. This work provides a potential therapeutic target for neural pathologic pain, and also sheds new lights on the abnormal sensory mechanisms associated with autism spectrum orders.
Source: Molecular Pain - Category: Molecular Biology Authors: Source Type: research