MeCP2 plays an analgesic role in pain transmission through regulating CREB / miR-132 pathway
Conclusions:
Our study shows that MeCP2 plays an analgesic role in both acute pain transduction and chronic pain formation through regulating CREB-miR-132 pathway. This work provides a potential therapeutic target for neural pathologic pain, and also sheds new lights on the abnormal sensory mechanisms associated with autism spectrum orders.
Source: Molecular Pain - Category: Molecular Biology Authors: Ran ZhangMin HuangZhijuan CaoJieyu QiZilong QiuLi-Yang Chiang Source Type: research
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