The absence of the leukotriene B 4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury

Conclusions:
Our data suggest that LTB4-BLT1 axis contributes not only to the peripheral inflammation but also to the neuronal activation in the spinal cord induced by intraplantar formalin injections. Thus, LTB4-BLT1 signaling is a potential target for therapeutic intervention of acute and persistent pain induced by tissue injury.

Source: Molecular Pain - March 12, 2015 Category: Molecular Biology Authors: Miho AsaharaNobuko ItoTakehiko YokomizoMotonao NakamuraTakao ShimizuYoshitsugu Yamada Source Type: research