Downregulation of miR-219 enhances brain-derived neurotrophic factor production in mouse dorsal root ganglia to mediate morphine analgesic tolerance by upregulating CaMKII{gamma}

Conclusions
These results demonstrate that miR-219 contributes to the development of chronic tolerance to morphine analgesia in mouse dorsal root ganglia by targeting CaMKII and enhancing CaMKII-dependent brain-derived neurotrophic factor expression.

Source: Molecular Pain - September 4, 2016 Category: Molecular Biology Authors: Hu, X.-M., Cao, S.-B., Zhang, H.-L., Lyu, D.-M., Chen, L.-P., Xu, H., Pan, Z.-Q., Shen, W. Tags: Research Article Source Type: research