Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain

Conclusions We provide evidence for modulation of nociceptive processing in a chronic knee osteoarthritis pain model with stronger brain activation and alteration of brain networks induced by the pro-nociceptive stimulus. We also report a shift to a medial pain activation pattern following stimulation of the hyperalgesic hindpaw. Taken together, our data support altered neural pain processing as a result of peripheral and central pain sensitization in this model.
Source: Molecular Pain - Category: Molecular Biology Authors: Tags: Research Article Source Type: research