Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain
Conclusions
We provide evidence for modulation of nociceptive processing in a chronic knee osteoarthritis pain model with stronger brain activation and alteration of brain networks induced by the pro-nociceptive stimulus. We also report a shift to a medial pain activation pattern following stimulation of the hyperalgesic hindpaw. Taken together, our data support altered neural pain processing as a result of peripheral and central pain sensitization in this model.
Source: Molecular Pain - Category: Molecular Biology Authors: Abaei, M., Sagar, D. R., Stockley, E. G., Spicer, C. H., Prior, M., Chapman, V., Auer, D. P. Tags: Research Article Source Type: research
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