The antiallodynic action of pregabalin in neuropathic pain is independent from the opioid system

Conclusions We demonstrate that neither acute nor long-term antiallodynic effect of pregabalin in a context of neuropathic pain is mediated by the endogenous opioid system, which differs from opioid treatment of pain and antidepressant treatment of neuropathic pain. Our data are also supportive of an impact of gabapentinoid treatment on the neuroimmune aspect of neuropathic pain.
Source: Molecular Pain - Category: Molecular Biology Authors: Tags: Research Article Source Type: research