Interferon-gamma potentiates NMDA receptor signaling in spinal dorsal horn neurons via microglia-neuron interaction

Conclusion
Our findings suggest that IFN enhance the amplitude of NMDA-induced inward currents in substantia gelatinosa neurons via microglial IFN receptors and CCL2/CCR2 signaling. This mechanism might be partially responsible for the development of persistent neuropathic pain.

Source: Molecular Pain - April 17, 2016 Category: Molecular Biology Authors: Sonekatsu, M., Taniguchi, W., Yamanaka, M., Nishio, N., Tsutsui, S., Yamada, H., Yoshida, M., Nakatsuka, T. Tags: Research Article Source Type: research