Synthesis and characterization of a disubstituted piperazine derivative with T-type channel blocking action and analgesic properties

Conclusions
Altogether, our data identify a novel T-type calcium channel blocker with tight structure activity relationship (SAR) and relevant in vivo efficacy in inflammatory pain conditions.

Source: Molecular Pain - April 5, 2016 Category: Molecular Biology Authors: Pudukulatham, Z., Zhang, F.-X., Gadotti, V. M., MDahoma, S., Swami, P., Tamboli, Y., Zamponi, G. W. Tags: Research Article Source Type: research