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27th Annual BSHI Conference, 13th –14th September 2016, Keble College, Oxford
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - August 22, 2016 Category: Genetics & Stem Cells Tags: BSHI 2016 Conference Abstracts Source Type: research

Nomenclature for factors of the HLA system, update May 2016
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - August 10, 2016 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

Nomenclature for factors of the HLA system, update April 2016
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - August 10, 2016 Category: Genetics & Stem Cells Authors: Steven G. E. Marsh Tags: Nomenclature Source Type: research

Tumour necrosis factor ‐alpha (‐308G/A) promoter polymorphism is associated with ulcerative colitis in Brazilian patients
This study aimed to analyse the gene polymorphisms in Brazilian patients with inflammatory bowel disease. A total of 101 patients diagnosed with inflammatory bowel disease were analysed for the tumour necrosis factor‐alpha (‐308 G/A; rs1800629) and interleukin‐10 (‐1082 G/A; rs1800896) gene polymorphisms. Genotyping was performed through polymerase chain reaction–sequence‐specific primer, then fractionated on 2% agarose gel and visualized after staining by ethidium bromide. The anatomic–clinical form of Crohn's disease (CD) predominant was the inflammatory (32.75%), followed by fistulizing (29.31%) and 27.5...
Source: International Journal of Immunogenetics - July 31, 2016 Category: Genetics & Stem Cells Authors: M. Tavares, C. Lima, W. Fernandes, V. Martinelli, M. Lucena, F. Lima, A. Telles, L. Brand ão, M. Melo Júnior Tags: Original Article Source Type: research

TNFSF4 polymorphisms are associated with systemic lupus erythematosus in the Malaysian population
Summary Tumour necrosis factor superfamily 4 (TNFSF4) gene has been reported to be associated with systemic lupus erythematosus (SLE) susceptibility due to its encoding for OX40L protein that can increase autoantibody production and cause imbalance of T‐cell proliferation. The purpose of this study was to investigate the association of TNFSF4 rs2205960, rs1234315, rs8446748 and rs704840 with SLE in the Malaysian population. A total of 476 patients with SLE and 509 healthy controls were recruited. Real‐time polymerase chain reaction (PCR) was applied to genotype the selected single nucleotide polymorphisms (SNPs). Allel...
Source: International Journal of Immunogenetics - July 31, 2016 Category: Genetics & Stem Cells Authors: K. H. Chua, Y. Y. Ooh, H. C. Chai Tags: Original Article Source Type: research

HLA ‐A, HLA‐B and HLA‐DRB1 allele and haplotype frequencies of 10 918 Koreans from bone marrow donor registry in Korea
Summary The human leucocyte antigen (HLA) system is the most polymorphic genetic system in humans, and HLA matching is crucial in organ transplantation, especially in hematopoietic stem cell transplantation. We investigated HLA‐A, HLA‐B and HLA‐DRB1 allele and haplotype frequencies at allelic level in 10 918 Koreans from bone marrow donor registry in Korea. Intermediate resolution HLA typing was performed using Luminex technology (Wakunaga, Japan), and additional allelic level typing was performed using PCR–single‐strand conformation polymorphism method and/or sequence‐based typing (Abbott Molecular, USA). All...
Source: International Journal of Immunogenetics - July 31, 2016 Category: Genetics & Stem Cells Authors: H. Park, Y. ‐j. Lee, E. Y. Song, M. H. Park Tags: Original Article Source Type: research

Nomenclature for factors of the HLA system, update June 2016
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - July 31, 2016 Category: Genetics & Stem Cells Authors: Steven G. E. Marsh Tags: Nomenclature Source Type: research

BSHI Guideline: HLA matching and donor selection for haematopoietic progenitor cell transplantation
Summary A review of the British Society for Histocompatibility and Immunogenetics (BSHI) “Guideline for selection and HLA matching of related, adult unrelated donors and umbilical cord units for haematopoietic progenitor cell transplantation” was undertaken by a BSHI appointed writing committee. Literature searches were performed, and the data extracted were presented as recommendations according to the GRADE nomenclature. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - July 31, 2016 Category: Genetics & Stem Cells Authors: A ‐M. Little, A. Green, J. Harvey, S. Hemmatpour, K. Latham, S. G. E. Marsh, K. Poulton, D. Sage Tags: Review Source Type: research

Association of interleukin ‐16 polymorphisms with disease progression and susceptibility in endometriosis
Summary Interleukin‐16 (IL‐16) is a multifunctional pro‐inflammatory cytokine that was previously found in association with complex disorders, and it is now cleared that this cytokine plays a critical role in regulation of cellular functions such as homoeostasis. Due to the complexity of endometriosis and its resemblance to cancer, we designed present case–control study to determine the effects of genetic polymorphisms of the human IL‐16 gene on Iranian women's susceptibility to endometriosis. A total of 126 patients with endometriosis (stages I–IV) and 144 healthy women as control group were recruited to the s...
Source: International Journal of Immunogenetics - July 31, 2016 Category: Genetics & Stem Cells Authors: P. Azimzadeh, H. R. Khorram Khorshid, M. M. Akhondi, A. Shirazi Tags: Original Article Source Type: research

Association of the HLA ‐G gene polymorphism with multiple sclerosis in a Polish population
In this study, three polymorphic sites in the HLA‐G gene: −725C>G>T, −716T>G and 14bpindel were genotyped. Significant differences were found between patients and controls in the alleles and genotypes for −725C>G>T and in three‐point haplotypes. We observed also a significant difference in the age of disease onset between patients positive and negative for 14bpins. The results suggest that single nucleotide polymorphisms in the promoter of the HLA‐G gene (mainly −725C>G>T), and 14bpindel, or some genetic marker in tight linkage disequilibrium with them are associated with multiple scleros...
Source: International Journal of Immunogenetics - July 22, 2016 Category: Genetics & Stem Cells Authors: A. Wi śniewski, M. Bilińska, A. Klimczak, M. Wagner, E. Majorczyk, I. Nowak, A. Pokryszko‐Dragan, P. Kuśnierczyk Tags: Short Communication Source Type: research

A novel HLA ‐B*14 allele – B*14:53 – genetics and serology
Summary HLA‐B*14:53 was found in a UK European normal blood donor prior to registration on the Welsh Bone Marrow Donor Registry. It differs from B*14:13 by one base (103G>T) in exon 2 resulting in a substitution of alanine (A) in B*14:13 to serine (S) in B*14:53. Unique among current HLA‐B*14 alleles, B*14:53 and B*14:13 share a motif of 59 bases between positions 361 and 419 in exon 3. This motif is present in numerous HLA‐B alleles the commonest overall being B*08:01, suggesting that both B*14:53 and B*14:13 arose from intralocus gene conversion events with B*08:01. Thus, B*14:53 probably arose from B*14:01:01 (...
Source: International Journal of Immunogenetics - June 15, 2016 Category: Genetics & Stem Cells Authors: J. Street, E. Davies, C. Darke Tags: Original Article Source Type: research

Detection of newly antibody ‐defined epitopes on HLA class I alleles reacting with antibodies induced during pregnancy
This report describes a HLAMatchmaker‐based analysis of 16 postpregnancy sera tested in single HLA‐ABC allele binding assays. Most sera reacted with alleles carrying epitopes that have been antibody‐verified, and this study focused on the reactivity of additional alleles that share other epitopes corresponding to eplets and other amino acid residue configurations. This analysis led in the identification of 16 newly antibody‐defined epitopes, seven are equivalent to eplets and nine correspond to combinations of eplets in combination with other nearby residue configurations. These epitopes will be added to the repert...
Source: International Journal of Immunogenetics - June 15, 2016 Category: Genetics & Stem Cells Authors: R. J. Duquesnoy, G. H önger, I. Hösli, M. Marrari, S. Schaub Tags: Original Article Source Type: research

Detection of newly antibody‐defined epitopes on HLA class I alleles reacting with antibodies induced during pregnancy
This report describes a HLAMatchmaker‐based analysis of 16 postpregnancy sera tested in single HLA‐ABC allele binding assays. Most sera reacted with alleles carrying epitopes that have been antibody‐verified, and this study focused on the reactivity of additional alleles that share other epitopes corresponding to eplets and other amino acid residue configurations. This analysis led in the identification of 16 newly antibody‐defined epitopes, seven are equivalent to eplets and nine correspond to combinations of eplets in combination with other nearby residue configurations. These epitopes will be added to the repert...
Source: International Journal of Immunogenetics - June 15, 2016 Category: Genetics & Stem Cells Authors: R. J. Duquesnoy, G. Hönger, I. Hösli, M. Marrari, S. Schaub Tags: Original Article Source Type: research

A novel HLA ‐B*40 allele, B*40:01:40, identified in a Chinese individual
Summary A new allele, officially named B*40:01:40, was detected in a Chinese individual by sequence‐based typing (SBT). The new allele differs from B*40:01:01 by a single nucleotide exchange at position 99 in codon 9, which results in synonymous substitution and seems not to compromise the HLA complex and T‐cell receptor interaction. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - June 14, 2016 Category: Genetics & Stem Cells Authors: Y. F. Pei, H. N. Huang, H. C. Li, W. D. Shen Tags: Short Communication Source Type: research

The common gamma chain cytokine interleukin ‐21 is expressed by activated lymphocytes from two macropod marsupials, Macropus eugenii and Onychogalea fraenata
Summary In mammals, interleukin‐21 is a member of the common gamma chain cytokine family that also includes IL‐2, IL‐4, IL‐7, IL‐9 and IL‐15. IL‐21 has pleiotropic effects on both myeloid and lymphoid immune cells and as a consequence, the biological actions of IL‐21 are broad: regulating both innate and adaptive immune responses and playing a pivotal role in antiviral, inflammatory and antitumour cellular responses. While IL‐21 genes have been characterized in mammals, birds, fish and amphibians, there are no reports for any marsupial species to date. We characterized the expressed IL‐21 gene from immu...
Source: International Journal of Immunogenetics - June 14, 2016 Category: Genetics & Stem Cells Authors: A. N. Suthers, J. M. Old, L. J. Young Tags: Original Article Source Type: research