Association of the HLA ‐G gene polymorphism with multiple sclerosis in a Polish population

In this study, three polymorphic sites in the HLA‐G gene: −725C>G>T, −716T>G and 14bpindel were genotyped. Significant differences were found between patients and controls in the alleles and genotypes for −725C>G>T and in three‐point haplotypes. We observed also a significant difference in the age of disease onset between patients positive and negative for 14bpins. The results suggest that single nucleotide polymorphisms in the promoter of the HLA‐G gene (mainly −725C>G>T), and 14bpindel, or some genetic marker in tight linkage disequilibrium with them are associated with multiple sclerosis.
Source: International Journal of Immunogenetics - Category: Genetics & Stem Cells Authors: Tags: Short Communication Source Type: research