International Journal of Immunogenetics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Nomenclature for factors of the HLA system, update September 2017
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - November 23, 2017 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: NOMENCLATURE Source Type: research

Associative role of HLA ‐DRB1 SNP genotypes as risk factors for susceptibility and severity of rheumatoid arthritis: A North‐east Indian population‐based study
This study aimed to evaluate the association of HLA‐DRB1 gene SNPs (rs13192471, rs660895 and rs6457617) with susceptibility and severity of RA in an ethnically distinct North‐east Indian population. Whole blood was collected from clinically characterized RA cases (satisfying the American College of Rheumatology 1987 criteria) (n = 123) and community‐based age and sex‐matched healthy controls (n = 156) with informed consent. The HLA‐DRB1 SNP analysis was performed for all the RA and control cases using ARMS‐PCR using case and control genomic DNA as template. Statistical analysis was performed by SPSSv13.0 so...
Source: International Journal of Immunogenetics - November 23, 2017 Category: Genetics & Stem Cells Authors: S. Das, C. Baruah, A. K. Saikia, S. Bose Tags: ORIGINAL ARTICLE Source Type: research

Nomenclature for factors of the HLA system, update July 2017
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - November 23, 2017 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: NOMENCLATURE Source Type: research

Jon Van Rood
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - November 15, 2017 Category: Genetics & Stem Cells Tags: OBITUARY Source Type: research

The maternal 14  bp Ins/Del polymorphism in HLA‐G is not associated with preeclampsia risk
Summary The effect of HLA‐G 14 bp Ins/Del polymorphism (rs371194629) on the risk of preeclampsia has been assessed in several populations, yet the results are still conflicting. Lack of power due to small sample sizes is a common cause of inconsistencies in genetic association studies. We aimed to test whether the maternal polymorphism is associated with preeclampsia, eclampsia or HELLP syndrome (acronym for Hemolysis, Elevation of Liver enzymes, Low Platelets). To achieve a statistical power greater than 0.90, a total of 741 women (332 controls, 246 preeclampsia, 57 eclampsia and 106 HELLP) were genotyped for the 14‐...
Source: International Journal of Immunogenetics - November 3, 2017 Category: Genetics & Stem Cells Authors: L. C. Ferreira, T. P. B. Lopes, T. B. Guimar ães, C. E. M. Gomes, S. M. B. Jeronimo Tags: ORIGINAL ARTICLE Source Type: research

Detection of monoclonal B cells in general population from two different regions of Mexico
Summary To estimate the frequency of monoclonal B cells in Mexican general population from two different regions of Mexico. Monoclonal B cells were detected by rearrangements of the immunoglobulin heavy chains (IGH) in 288 individuals: 188 from a metropolitan area and 100 from a rural area. After DNA extraction from peripheral blood by the CTAB/DTAB method, multiplex PCR was used to amplify the IGH rearrangements, followed by capillary electrophoresis. In together, 9.4% of the studied individuals showed monoclonal B cells. This prevalence is significantly higher to those previously described for other populations, but simi...
Source: International Journal of Immunogenetics - October 22, 2017 Category: Genetics & Stem Cells Authors: Sergio Yair Rodr íguez‐Preciado, María Teresa Magaña‐Torres, Ana Rebeca Jaloma Cruz, Patricio Barros‐Núñez Tags: ORIGINAL ARTICLE Source Type: research

Current immunogenetic predisposition to tuberculosis in the Moroccan population
Summary Tuberculosis (TB) is a serious infectious disease that kills approximately two million people per year, particularly in low‐ and middle‐income countries. Numerous genetic epidemiology studies have been conducted of many ethnic groups worldwide and have highlighted the critical impact of the genetic environment on TB distribution. Many candidate genes associated with resistance or susceptibility to TB have been identified. In Morocco, where TB is still a major public health problem, various observations of clinical, microbiological and incidence distribution are heavily affected by genetic background and externa...
Source: International Journal of Immunogenetics - October 22, 2017 Category: Genetics & Stem Cells Authors: M. Qrafli, M. Najimi, R. Elaouad, K. Sadki Tags: REVIEW Source Type: research

Association between killer cell immunoglobulin ‐like receptor 2DS5 gene with essential hypertension in the Chinese Han patients
Summary Hypertension has been suggested to be mediated by immunity and inflammation. As immune system genes, killer cell immunoglobulin‐like receptors (KIRs) genes play an important role in the pathogenesis of autoimmune diseases. We conducted a community population‐based case–control study to analyse associations between KIR genes and hypertension. KIR genes were genotyped using sequence‐specific primer polymerase chain reaction in 380 unrelated essential hypertensives and 527 normotensives. The frequencies of KIR2DS5 gene were significantly decreased in participants with high high‐sensitivity C‐reactive prote...
Source: International Journal of Immunogenetics - October 1, 2017 Category: Genetics & Stem Cells Authors: A. L. Wang, B. Jiang, X. Y. Qian, Q. Zhang, H. Peng, Y. H. Zhang Tags: ORIGINAL ARTICLE Source Type: research

Characterization of a novel HLA ‐B*39:01:01‐related allele, HLA‐B*39:130, by cloning and phasing
Summary A novel HLA‐B*39:01:01‐related variant, HLA‐B*39:130, has been identified in a normal individual of Han ethnicity in Hunan province, southern China. Following Sanger polymerase chain reaction–sequence‐based typing (PCR‐SBT), this new allele was further confirmed by cloning, phasing and sequencing. Aligned with HLA‐B*39:01:01, HLA‐B*39:130 has a nonsynonymous thymine substitution at nucleotide position 94 in exon 4, resulting in amino acid change from threonine to isoleucine at codon 214 (ACA→ATA) of the mature HLA‐BmRNA molecule. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - October 1, 2017 Category: Genetics & Stem Cells Authors: L. X. Li, W. Tian, F. M. Zhu, W. Y. Wang, J. H. Cai Tags: SHORT COMMUNICATION Source Type: research

Genotype frequencies of human neutrophil antigen ‐3 in the Chinese Zhuang and Dong populations
This study showed Chinese Zhuang and Dong populations possessed a higher frequency of HNA‐3b/3b genotype, suggesting that they may be at greater risk for developing anti‐HNA‐3a alloantibodies that may cause severe cases of TRALI. A molecular‐based identification of the HNA‐3b/3b genotype in all multiparous female blood donors was suggested to reduce the risk of TRALI following plasma and whole blood allogeneic transfusions. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - October 1, 2017 Category: Genetics & Stem Cells Authors: X. Liao, H. Li, W. Jiao, C. Zhu, W. Wang, Z. Mo, Z. Yang, Z. Zhu Tags: ORIGINAL ARTICLE Source Type: research

Three novel mutations in CYBA among 22 Iranians with Chronic granulomatous disease
In this study, new genetic changes of CYBA gene in 22 Iranian patients with autosomal recessive‐CGD (AR‐CGD) were identified. Twenty‐two patients with CGD were referred to Immunology, Asthma and Allergy Research Institute (IAARI) and enrolled in this study based on defect in NADPH oxidase activity, demographic data and clinical histories. All patients had p22‐phox deficiency based on Western blotting. Genomic DNA was extracted from peripheral blood mononuclear cells (PBMCs), and PCR followed by direct sequencing was performed to find p22‐phox mutations. Mutation analysis of CYBA revealed 12 different mutations, i...
Source: International Journal of Immunogenetics - September 20, 2017 Category: Genetics & Stem Cells Authors: M. Badalzadeh, S. Tajik, M. R. Fazlollahi, M. Houshmand, F. Fattahi, Z. Alizadeh, M. Movahedi, Z. Adab, G. T. Khotaei, A. A. Hamidieh, H. Heidarnazhad, Z. Pourpak Tags: ORIGINAL ARTICLE Source Type: research

HLA ‐G gene 14‐bp deletion variant protects Iranian subjects against chronic hepatitis B infection
This study was performed on a total of 396 individuals including 199 CHB patients and 197 healthy subjects from a south‐east Iranian population. We genotyped 14‐bp Ins/Del polymorphism in the HLA‐G gene using polymerase chain reaction method. The results of our study revealed that the HLA‐G 14‐bp deletion polymorphism was associated with a reduced risk of CHB at both allele and genotypic levels. The 14‐bp Del allele and Ins/Del genotype were more frequent in control group than in CHB patients (37% vs 28% for Del allele with OR = 0.68 and p‐value = .015; 73% vs 52% for Ins/Del genotype with OR = 0.43 and...
Source: International Journal of Immunogenetics - September 20, 2017 Category: Genetics & Stem Cells Authors: E. Eskandari, T. Dahmardeh, V. Safdari, S. Khosravi, E. Pahlevani Tags: ORIGINAL ARTICLE Source Type: research

Association of human platelet antigens polymorphisms with susceptibility to hepatitis C virus infection in Chinese population
Summary Hepatitis C virus (HCV) is a major cause of chronic hepatitis. Previous studies have identified a number of single nucleotide polymorphisms that are associated with HCV infection. Human platelet antigens (HPAs) polymorphisms play an important role in several diseases. Here, we demonstrated the association of the HPA‐2, HPA‐3, HPA‐5 and HPA‐15 polymorphisms with susceptibility to HCV infection in Chinese population. Overall, 118 patients with HCV and 167 controls were genotyped for HPAs. There were no significant differences in the allele and genotype frequency distribution for the HPA‐3, HPA‐5 and HPA�...
Source: International Journal of Immunogenetics - September 20, 2017 Category: Genetics & Stem Cells Authors: S. ‐h. Zhou, X.‐h. Liang, L.‐n. Shao, W.‐j. Yu, C. Zhao, M. Liu Tags: ORIGINAL ARTICLE Source Type: research

The association between MICA/MICB polymorphism and respiratory syncytial virus infection in children
In conclusion, allele MICA*002:01/A9 and haplotype MICA*002:01‐MICB*005:02 were negatively associated with RSV respiratory tract infections. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - September 19, 2017 Category: Genetics & Stem Cells Authors: Q. Luo, X. Guo, S. Peng, W. Luo, F. Tian, P. Yu, Y. Zou Tags: ORIGINAL ARTICLE Source Type: research

Abstracts for the 28th Annual BSHI Conference, Leamington Spa, UK, 3rd –4th October 2017
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - September 6, 2017 Category: Genetics & Stem Cells Tags: ABSTRACTS Source Type: research