International Journal of Immunogenetics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Nomenclature for factors of the HLA system, update February 2016
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - May 3, 2016 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

Prediction and preliminary screening of HLA‐A*0201‐restricted epitope peptides of human GPC3
In this study, potential HLA‐A*0201 GPC3 peptides were screened with three epitope prediction software, the binding affinity of 13 predicted epitopes with high scores was determined by T2 cells binding assay and four optimal epitopes were identified. This is the first study in which the optimal HLA‐A*0201 GPC3 epitopes were screened from a large number of candidates predicted by three software. The optimized HLA‐A*0201 GPC3 peptides will provide new epitope candidates for HCC immunotherapy. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - April 21, 2016 Category: Genetics & Stem Cells Authors: P. Hu, Z. Wei, R. Li, D. Wu, Z. Meng Tags: Original Article Source Type: research

Molecular comparison of Slc11a1 and Slc11a2 genes of swamp‐ and riverine‐type water buffaloes
This study analysed the genetic characteristic of Slc 11a and 11a2 in swamp‐type and riverine‐type water buffaloes to understand their immunological distinction. Characterization of Slc11a1 and Slc11a2 genes from swamp‐ and riverine‐type water buffaloes was carried out by molecular cloning, sequencing and phylogenetic analysis. The cloned cDNA of Slc11a1 and Slc11a2 contained an open reading frame of 1647 and 1723 nucleotides, encoding 549 and 574 amino acids, respectively. Nucleotide sequence homology of both Slc11a1 and Slc11a2 had 99% in swamp and riverine type, which gives almost identical polypeptide. However,...
Source: International Journal of Immunogenetics - April 18, 2016 Category: Genetics & Stem Cells Authors: R. B. C. Padiernos, C. N. Mingala Tags: Original Article Source Type: research

HLA‐G 14‐bp polymorphism affects the age of onset in Type I Diabetes Mellitus
This study investigates the involvement of a 14‐bp deletion polymorphism (rs371194629) at the 3′ untranslated region of HLA‐G in the context of T1DM and age of onset. The frequency of the polymorphism was determined in unrelated T1DM Cypriot patients and findings that emerge from this study show a strong association between the HLA‐G 14‐bp polymorphism and T1DM with respect to the age of onset. Specifically, the deletion/deletion (DEL/DEL) genotype was found to be associated with an early age of onset (P = 0.001), while the presence of the insertion allele (INS) was associated to a later age of onset (P = 0.0...
Source: International Journal of Immunogenetics - April 14, 2016 Category: Genetics & Stem Cells Authors: P. Gerasimou, N. Skordis, M. Picolos, A. Spyridonidis, P. Costeas Tags: Original Article Source Type: research

Nomenclature for factors of the HLA system, update January 2016
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - March 31, 2016 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

Association between interleukin‐21 gene polymorphisms (rs12508721) and HBV‐related hepatocellular carcinoma
Summary Interleukin‐21 (IL‐21), as a multifunctional cytokine, plays an important role in many diseases, such as cancer, inflammatory and autoimmune diseases. We aimed to investigate the relationship between polymorphisms of IL‐21 gene and susceptibility of hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC) in a Chinese population. Studied subjects were divided into three groups: 100 patients with HBV‐related HCC, 115 patients with chronic HBV infection and 127 healthy controls. Genomic DNA was isolated from peripheral blood, and the polymerase chain reaction–ligase detection reaction (PCR‐LDR) me...
Source: International Journal of Immunogenetics - March 31, 2016 Category: Genetics & Stem Cells Authors: Q. X. Zhang, S. L. Li, Y. Q. Yao, T. J. Li Tags: Original Article Source Type: research

Susceptible and protective associations of HLA DRB1*/DQB1* alleles and haplotypes with ischaemic stroke
Summary Stroke has emerged as the second commonest cause of mortality worldwide and is a major public health problem. For the first time, we present here the association of human leucocyte antigen (HLA)‐DRB1*/DQB1* alleles and haplotypes with ischaemic stroke in South Indian patients. Ischaemic stroke (IS) cases and controls were genotyped for HLA‐DRB1*/DQB1* alleles by polymerase chain reaction sequence‐specific primers (PCR‐SSP) method. The frequencies of HLA class II alleles such as DRB1*04, DRB1*07, DRB1*11, DRB1*12, DRB1*13, DQB1*02 and DQB1*07 were high in IS patients than in the age‐ and gender‐matched c...
Source: International Journal of Immunogenetics - March 31, 2016 Category: Genetics & Stem Cells Authors: V. Murali, C. Rathika, S. Ramgopal, R. Padma Malini, M. J. Arun Kumar, V. Neethi Arasu, K. Jeyaram Illiayaraja, K. Balakrishnan Tags: Original Article Source Type: research

The possible role of the tumour necrosis factor polymorphisms and human leucocyte antigens in the development of prostate cancer
Summary The cause of prostate cancer (PC), one of the most common cancers found among ageing men, remains unclear, but genetic predisposition is believed to play a major role in its aetiology. The aim of the study was to examine HLA genes polymorphism and TNF polymorphisms in PC development. Patients diagnosed with PC (N = 113) and 150 healthy individuals were tested for HLA‐A, HLA‐B and HLA‐DRB1 genes and for TNFa, TNFb and TNFd microsatellites. The comparison of patients and controls revealed a positive association of HLA‐DRB1*12, TNFa2 and TNFb5, and a negative association of HLA‐DRB1*13 and TNFb4 with PC. A...
Source: International Journal of Immunogenetics - March 31, 2016 Category: Genetics & Stem Cells Authors: K. Stingl Jankovic, T. Hudolin, Z. Kastelan, R. Zunec, Z. Grubic Tags: Original Article Source Type: research

Association of TIM‐1 5383‐5397ins/del and TIM‐3 ‐1541C>T polymorphisms with multiple sclerosis in Isfahan population
In this study, for the first time, the association of TIM‐1 5383‐5397ins/del and TIM‐3 ‐1541C>T polymorphisms with MS in an Iranian population was considered. The results of our study showed that there is no significant association between TIM‐1 5383‐5397ins/del and MS (P = 0.38); however, the frequency of CT genotype of TIM‐3 ‐1541C>T in patient group was significantly higher than the control group, and there was a significant association between CT genotype and MS (P = 0.009, OR = 4.08). (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - March 31, 2016 Category: Genetics & Stem Cells Authors: F. Mazrouei, M. Ganjalikhani‐Hakemi, R. Salehi, F. Alesahebfosoul, M. Etemadifar, M. Pouladian, R. Meshkat, Sh. Nekoueian, H. Zarkesh‐Esfahani, M. Ziyaee‐Ghahnaviyeh Tags: Original Article Source Type: research

Genomic full‐length sequence of a novel HLA‐A*11:01:01:02 allele was identified in a Chinese bone marrow donor
Summary Here, we report genomic full‐length sequence of a novel HLA‐A*11:01:01:02 allele identified in a Chinese individual. HLA‐A*11:01:01:02 has three nucleotide differences from HLA‐A*11:01:01:01, including 99 C>G of intron 1, 655 C>T and G deletion in position 656 of intron 2. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - March 31, 2016 Category: Genetics & Stem Cells Authors: J. He, Y. He, W. Wang, Z. Han, J. He, N. Chen, L. Dong, S. Tao, W. Zhang, F. Zhu Tags: Short Communication Source Type: research

HLA‐B allele dropout in PCR sequence‐specific oligonucleotide probe typing due to intronic polymorphism in the novel B*58:01:01:02 allele
Summary Currently, Luminex technology based on the PCR sequence‐specific oligonucleotide (SSO) probe method has been widely used for HLA genotyping in the immunogenetics laboratories. Here, we reported a case with HLA‐B allele dropout by Luminex technology. The initial HLA‐B result of the Luminex method with a commercial agent kit was inconclusive, and then, the result of PCR‐SBT technology indicated the dropout as a HLA‐B*58 allele. Subsequently, the full‐length sequence of HLA‐B allele was determined by TOPO‐TA cloning, and a novel allele B*58:01:01:02 was identified in the individual. Compared with HLA�...
Source: International Journal of Immunogenetics - March 26, 2016 Category: Genetics & Stem Cells Authors: Y. He, W. Wang, Z. Han, J. He, N. Chen, L. Dong, S. Tao, W. Zhang, J. He, F. Zhu, H. Lv Tags: Original Article Source Type: research

Interactions between maternal killer cell immunoglobulin receptor genes and foetal HLA ligand genes contribute to type 1 diabetes susceptibility in Han Chinese
In this study, we aimed to test the hypothesis that KIR haplotypes (that interact with HLA class I molecules) are associated with susceptibility in patients with T1DM in utero through maternal–foetal interaction of KIR and their HLA class I ligands in Han Chinese population. We determined the KIR genes and KIR/ligand gene combination frequencies in 59 Han Chinese children with T1D and their mothers and compared it with 159 healthy control children and their mothers. The absence of KIR‐2DS1 in the mother and the presence of HLA‐C2 ligand in the child were negatively associated with type 1 diabetes in the child. Our re...
Source: International Journal of Immunogenetics - March 17, 2016 Category: Genetics & Stem Cells Authors: C. Sun, S. Sanjeevi, F. Luo, D. Zhi, C. B Sanjeevi Tags: Original Article Source Type: research

Variations in genes involved in regulation of the nuclear factor – κB pathway and the risk of acute myeloid leukaemia
In conclusion, polymorphisms within the TLR9 and TRAF3 genes are associated with predisposition to AML and may affect the progression of the disease in the Polish population. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - February 25, 2016 Category: Genetics & Stem Cells Authors: J. Rybka, K. Gębura, T. Wróbel, B. Wysoczańska, E. Stefanko, K. Kuliczkowski, K. Bogunia‐Kubik Tags: Original Article Source Type: research

Nomenclature for factors of the HLA system, update November 2015
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - February 12, 2016 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

Nomenclature for factors of the HLA system, update December 2015
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - February 12, 2016 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research