International Journal of Immunogenetics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Nomenclature for factors of the HLA system, update July 2015
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - November 6, 2015 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

Nomenclature for factors of the HLA system, update September 2015
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - October 1, 2015 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

The dichotomy between disease phenotype databases and the implications for understanding complex diseases involving the major histocompatibility complex
Summary Many genes related to innate and adaptive immunity reside within the major histocompatibility complex (MHC) and have been associated with a multitude of complex, immune‐related disorders. Despite years of genetic study, this region has seen few causative determinants discovered for immune‐mediated diseases. Reported associations have been curated in various databases including the Genetic Association Database, NCBI database of clinically relevant variants (ClinVar) and the Human Gene Mutation Database and together capture genetic associations and annotated pathogenic loci within the MHC and across the genome fo...
Source: International Journal of Immunogenetics - October 1, 2015 Category: Genetics & Stem Cells Authors: P. M. Clark, M. Kunkel, D. S. Monos Tags: Review Source Type: research

Molecular characterization of T‐cell immunoglobulin mucin domain‐3 and Galectin‐9 genes of swamp‐ and riverine‐type water buffaloes
Summary Molecular characterization of T‐cell immunoglobulin mucin domain‐3 (TIM‐3) and Galectin‐9 (GAL‐9) genes of swamp‐ and riverine‐type water buffaloes was conducted to compare these genes with other species; determine the unique characteristic specific in water buffalo; and provide baseline information for the assessment of disease progression in buffalo species. TIM‐3 and GAL‐9 genes were amplified, purified, sequenced and characterized. The sequence result of TIM‐3 in both types of water buffaloes contained 843 nucleotides encoding to 280 amino acids while GAL‐9 of swamp‐type and riverine‐t...
Source: International Journal of Immunogenetics - October 1, 2015 Category: Genetics & Stem Cells Authors: P. L. H. Duran, R. B. C. Padiernos, E. A. Abella, S. Konnai, C. N. Mingala Tags: Original Article Source Type: research

IL‐1A rs1800587, IL‐1B rs1143634 and IL‐1R1 rs2234650 polymorphisms in Iranian patients with systemic sclerosis
In this study, we investigated SNPs of the IL‐1 gene cluster in Iranian SSc patients. We obtained blood samples from 170 SSc patients and 213 healthy individuals. Cytokine genotyping results were obtained by polymerase chain reaction with sequence‐specific primers (PCR‐SSP). IL‐1A rs1800587, IL‐1B rs1143634 and IL‐1R1 rs2234650 were evaluated for SNP study. The frequency of the IL‐1B rs1143634 CT genotype was significantly lower in SSc patients compared to the controls (OR = 0.584; 95% CI = 0.385–0.886; P‐value = 0.023), so we propose that CT genotype of this allele might be protective. According to...
Source: International Journal of Immunogenetics - September 29, 2015 Category: Genetics & Stem Cells Authors: S. Abtahi, A. Farazmand, M. Mahmoudi, A. Ashraf‐Ganjouei, A. Javinani, B. Nazari, H. Kavosi, A. A. Amirzargar, A. R. Jamshidi, F. Gharibdoost Tags: Original Article Source Type: research

HLA‐A locus allelic dropout in Sanger sequence‐based typing due to the single nucleotide polymorphism of exon 1
Summary The DNA‐based method is used widely for HLA genotyping in routine work, but some allele may be dropout in the genotyping procedure. Here, we reported a case with HLA‐A allele dropout in the Sanger PCR‐SBT test. The initial PCR‐SBT method with a commercial agent kit was not characterized, and the result of Luminex technology indicated the dropout as a HLA‐A*02 allele. Subsequently, the sequences of exons 2–4 were fully matched with the A*02:07 and A*11:01:01 by allele group‐specific primer amplification PCR‐SBT. On further analysis, a novel allele A*02:07:07 was identified, which has one nucleotide d...
Source: International Journal of Immunogenetics - September 20, 2015 Category: Genetics & Stem Cells Authors: W. Zhang, Y. He, W. Wang, Z. Han, J. He, N. Chen, L. Dong, S. Tao, J. He, F. Zhu, H. Lv Tags: Original Article Source Type: research

CTLA4+49G allele associates with early onset of type 1 diabetes in North Indians
In this study, we investigated +49A/G SNP (rs 231775) in exon 1 of cytotoxic T‐lymphocyte‐associated antigen 4 (CTLA4) by PCR‐RFLP and its influence as a risk factor for the disease in the North Indian population. This polymorphism at codon 17 results in an amino acid substitution (Thr/Ala) in the leader peptide of the molecule. The study included 232 patients with T1D (age at onset of disease (AOD): 0.5–37 years) and 305 ethnically matched healthy controls. The DNA obtained from these 537 individuals was amplified using a set of specific primers followed by restriction enzyme digestion with Fnu4HI. The +49G allel...
Source: International Journal of Immunogenetics - September 19, 2015 Category: Genetics & Stem Cells Authors: N. Kumar, G. Kaur, U. Kanga, N. K. Mehra, S. C. Neolia, N. Tandon, S. C. Zucman Tags: Original Article Source Type: research

Adaptive evolution of the MHC class III‐encoded receptor RAGE in primates and murine rodents
Summary The receptor for advanced glycation end products is associated with a series of physiological and pathological processes. Here, we studied the evolution of this multiligand receptor in primates and murine rodents. The evolutionary analyses reveal that adaptive selection had contributed to the variation at a number of amino acid sites in both taxa. Further, the major adaptively selected sites of both taxa are located on the extracellular ligand‐ and intracellular adaptor‐binding regions and receptor oligomerization‐related surfaces. The co‐occurrence of adaptive evolution on the homologue domains suggests th...
Source: International Journal of Immunogenetics - September 19, 2015 Category: Genetics & Stem Cells Authors: X. Wu, J. Wu, C. W. Thompson, Y. Li Tags: Original Article Source Type: research

Profile of killer cell immunoglobulin‐like receptor and its human leucocyte antigen ligands in dengue‐infected patients from Western India
In this study, 114 hospitalized cases of dengue [82 dengue fever (DF) and 32 dengue haemorrhagic fever (DHF) cases] and 104 healthy controls (HC) without no known history of hospitalization for dengue‐like illness were investigated for their KIR gene profile to find out the association of KIR genes with dengue disease severity. KIR gene profile was investigated using duplex sequence‐specific priming polymerase chain reaction‐based typing system. The results revealed a higher frequency of KIR3DL1 gene [P = 0.0225; odds ratio (OR) 4.1 95% confidence interval (CI) 1.1–14.8] and lower frequency of KIR3DS1/3DS1 genoty...
Source: International Journal of Immunogenetics - September 19, 2015 Category: Genetics & Stem Cells Authors: K. Alagarasu, R. V. Bachal, P. S. Shah, D. Cecilia Tags: Original Article Source Type: research

Association of complement factor B allotypes and serum biomarkers in rheumatoid arthritis patients and their relatives
Summary The aim of the study was to investigate the allotypic variability of complement factor B (BF) in patients and relatives with rheumatoid arthritis (RA) and its association with serological biomarkers and clinical features of the disease. BF allotypes were determined by high‐voltage agarose gel electrophoresis in serum samples of 180 patients with RA, 198 relatives and 98 controls from Southern Brazil. Anticyclic citrullinated peptide (anti‐CCP), antimutated citrullinated vimentin (anti‐MCV) and IgA‐rheumatoid factor (RF) were determined by ELISA and IgM‐RF by latex agglutination in all samples. No signific...
Source: International Journal of Immunogenetics - September 19, 2015 Category: Genetics & Stem Cells Authors: F. R. Nass, T. L. Skare, I. Goeldner, R. Nisihara, I. J. Messias‐Reason, S. R. R. Utiyama Tags: Original Article Source Type: research

Association study of interleukin‐1 family and interleukin‐6 gene single nucleotide polymorphisms in recurrent aphthous stomatitis
Summary Recurrent aphthous stomatitis (RAS) is a common painful, ulcerative oral inflammatory disorder with unknown aetiology. Immune system and aberrant cytokine cascade deemed to be critical in outbreaks of RAS ulcers. Interleukin‐1 (IL‐1) and IL‐6 are the most potent pro‐inflammatory cytokines. Single nucleotide polymorphisms (SNPs) of IL‐1 and IL‐6 genes can affect the secretion of these cytokines. The aim of this study was to investigate the association between RAS and IL‐6 and IL‐1 in Iranian subjects with minor RAS. Genomic DNA was obtained from 64 Iranian patients with RAS. IL‐1α C −889 T, IL�...
Source: International Journal of Immunogenetics - September 18, 2015 Category: Genetics & Stem Cells Authors: S. Najafi, H. Yousefi, M. Mohammadzadeh, A. Z. Bidoki, I. Firouze Moqadam, E. Farhadi, A. A. Amirzargar, N. Rezaei Tags: Original Article Source Type: research

Can ficolin‐2 (L‐ficolin) insufficiency be established by a single serum protein measurement?
Summary Serum ficolin‐2 was measured in multiple (2‐27) samples from 68 paediatric sepsis patients. Fourteen individuals (21%) gave values that included a change in status from ‘normal’ to ‘insufficient’ or vice versa. Therefore, if possible, ficolin‐2 concentration should be determined in samples obtained when a disease is inactive. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - September 18, 2015 Category: Genetics & Stem Cells Authors: D. C. Kilpatrick, A. S. Świerzko, M. Sobociński, W. Krajewski, K. Chojnacka, J. Szczapa, M. Cedzyński Tags: Short Communication Source Type: research

26th British Society for Histocompatibility and Immunogenetics Conference
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - August 25, 2015 Category: Genetics & Stem Cells Tags: BSHI Conference Abstracts Source Type: research

Analysis of the association between IL‐23R rs11209026 polymorphism and incidence of atherosclerosis
Summary Th17/IL‐23 axis is an important pro‐inflammatory pathway in atherosclerosis. IL‐23 receptor (IL‐23R) pathway has an important role in T‐helper cells 17 (Th17) differentiation and survival. We compared normal subjects and patients with atherosclerosis in terms of the R381Q variant of the IL‐23R gene as a functional single‐nucleotide polymorphism (SNP). This case–control study recruited 200 patients who presented with cardiovascular symptoms to Afshar Hospital, Yazd, Iran. The participants were allocated to five groups based on angiographic results. The severity of the disease was determined according...
Source: International Journal of Immunogenetics - August 11, 2015 Category: Genetics & Stem Cells Authors: M. Kave, M. Shadman, A. Alizadeh, M. Samadi Tags: Original Article Source Type: research

HLA B51 is associated with faster AIDS progression among newly diagnosed HIV‐infected individuals in Manitoba, Canada
We report, for the first time, faster CD4 decline among individuals with HLA B51 allele. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - August 1, 2015 Category: Genetics & Stem Cells Authors: Y. Keynan, Z. V. Rueda, K. Bresler, M. Becker, K. Kasper Tags: Original Article Source Type: research