International Journal of Immunogenetics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Human leucocyte antigen –adverse drug reaction associations: from a perspective of ethnicity
Summary Whilst immune‐mediated adverse drug reactions (ADRs) are rare, they are potentially life‐threatening and present a major problem for clinicians. The underlying mechanisms that cause ADRs are not fully understood although genomewide association studies (GWAS) and case–control investigations have associated human leucocyte antigen (HLA) alleles as risk factors. There is evidence that a patient's ethnic background can have an impact on their risk of developing an ADR. This review summarizes the evidence related to HLA alleles and ADRs with particular focus on patient ethnicity. Our analysis indicated that many o...
Source: International Journal of Immunogenetics - January 15, 2017 Category: Genetics & Stem Cells Authors: G. S. Ghattaoraya, D. Middleton, E. J. M. Santos, R. Dickson, A. R. Jones, A. Alfirevic Tags: Review Source Type: research

Identification and characterization a novel HLA ‐A allele, A*02:355, by sequence‐based typing in a Chinese potential donor
Summary The new allele A*02:355 differs from A* 02:03:01 at positions 98 (T→A) and 102(A→C) resulting in an amino acid exchange F9→T. Interallelic sequence exchange is more likely the mechanism of its origination. The amino acid replacement influences the HLA peptide binding cleft and might have significant functional effects. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - January 1, 2017 Category: Genetics & Stem Cells Authors: X ‐M. Nie, Y. Zhang, W‐B. Qiao, C‐F. Zhu, Y‐R. Zhao Tags: Short Communication Source Type: research

Exon 2 sequencing of the new HLA ‐DRB1 allele, DRB1*13:216
Summary A novel HLA‐DRB1*13:216 allele was characterized in a Spanish bone marrow donor. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - November 30, 2016 Category: Genetics & Stem Cells Authors: D. Planelles, A. Balas, R. Alenda, J. L. Vicario Tags: Short Communication Source Type: research

Modulation of alloimmune response by commensal gut microbiota and potential new avenues to influence the outcome of allogeneic transplantation by modification of the ‘gut culture’
Summary Host defence response against microbial infections was the foundation for the Science of Immunology. Now, we know the mechanisms of such host defence which include innate immune responses that is generally nonspecific but effective in many cases and lead to more specific responses called adaptive immune response. The gene loci of class I, II and III of the major histocompatibility complex (MHC) play a major role in directing the adaptive immune responses by presenting processed antigens to T and B cells to induce appropriate antigen‐specific cellular and or humoral immune responses. In humans, these are commonly ...
Source: International Journal of Immunogenetics - November 30, 2016 Category: Genetics & Stem Cells Authors: S. Kanangat Tags: Review Source Type: research

HLA ‐DQA1 and HLA‐DQB1 allele diversity and its extended haplotypes in Madeira Island (Portugal)
This study shows, for the first time, high‐resolution allele frequencies of HLA‐DQA1 loci in Madeira Island (Portugal) and allows us to better understand and refine present knowledge on DQB1 variation, with the identification of several alleles not previously reported in this population. Estimates on haplotype profile, involving HLA‐A, HLA‐B, HLA‐DRB1, HLA‐DQA1 and HLA‐DQB1, are also reported. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - November 30, 2016 Category: Genetics & Stem Cells Authors: H. Sp ínola, A. Lemos, A. R. Couto, B. Parreira, M. Soares, I. Dutra, J. Bruges‐Armas, A. Brehm Tags: Short Communication Source Type: research

Confirmation and next ‐generation sequencing of allele HLA‐B*35:279 found in a family of a leukaemia patient with Western Asia origin
Summary The confirmation of novel allele HLA‐B*35:279 in a family of a leukaemia patient with Western Asia origin is reported. Moreover, next‐generation sequencing (NGS) resulted in whole‐gene sequence data and revealed the inheritance of HLA‐B*35:279 on the paternal haplotype. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - November 30, 2016 Category: Genetics & Stem Cells Authors: F. Gr ünebach, A.‐L. Huster, W. Vogel, R. Klein Tags: Short Communication Source Type: research

Clinical and immunological relevance of antibodies in solid organ transplantation
Summary The two important issues affecting recipients of solid organ transplants and of importance to immunologists are (i) sensitization of the recipient to HLA antigens and the resultant humoral immune response leading to the development of anti‐HLA antibodies; and ii) development of robust assays for early detection of humoral rejection post‐transplant. Evidence from several studies clearly indicates that presence of circulating anti‐HLA antibodies especially donor specific leads to early graft loss and high titres of DSA may even lead to hyperacute or accelerated acute rejection. Long‐term graft survival too is...
Source: International Journal of Immunogenetics - November 15, 2016 Category: Genetics & Stem Cells Authors: N. K. Mehra, A. K. Baranwal Tags: Review Source Type: research

Nomenclature for factors of the HLA system, update July 2016
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - November 8, 2016 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

Impact of genomic risk factors on survival after haematopoietic stem cell transplantation for patients with acute leukaemia
This study is novel as it focuses only on patients having acute leukaemia (N = 458) and attempts to demonstrate how non‐HLA gene polymorphisms can be added to the EBMT risk score in a Cox regression model to improve prognostic ability for overall survival. The results of the study found that three genetic factors improved EBMT risk score. The presence of MAL (rs8177374) allele T in the patient, absence of glucocorticoid receptor haplotype (consisting of rs6198, rs33389 and rs33388) ACT in the patient and absence of heat‐shock protein 70‐hom (+2437) (rs2227956) allele C in the patient were associated with decreased ...
Source: International Journal of Immunogenetics - November 8, 2016 Category: Genetics & Stem Cells Authors: K. F. Pearce, Y. Balavarca, J. Norden, G. Jackson, E. Holler, R. Dressel, H. Greinix, A. Toubert, E. Gluckman, I. Hromadnikova, P. Sedlacek, D. Wolff, U. Holtick, H. Bickeb öller, A. M. Dickinson Tags: Original Article Source Type: research

IL ‐12B and IL‐10 gene polymorphisms in the development of Hashimoto's thyroiditis
This study was designed to compare −1082A/GIL‐10 and +1188A/C3′UTRIL‐12B genotype distribution in 130 patients with HT to a group of 157 healthy controls in attempts to determine an association with HT development. Genotyping for the 3′UTRA/C IL‐12B polymorphism was performed using RFLP‐PCR and genotyping for −1082A/G IL‐10 by ARMS‐PCR assay. Patients with HT were divided into euthyroid and hypothyroid stages. There were no significant differences in the genotype and allele frequencies of the IL‐12B polymorphism between patients with HT and controls. We observed higher euthyroid HT risk for individual...
Source: International Journal of Immunogenetics - October 23, 2016 Category: Genetics & Stem Cells Authors: J. Gerenova, S. Stanilova Tags: Original Article Source Type: research

Nomenclature for factors of the HLA system, update September 2016
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - September 30, 2016 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

Nomenclature for factors of the HLA system, update August 2016
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - September 30, 2016 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

Human leucocyte antigen class I and II imputation in a multiracial population
Summary Human leucocyte antigen (HLA) genes play a central role in response to pathogens and in autoimmunity. Research to understand the effects of HLA genes on health has been limited because HLA genotyping protocols are labour intensive and expensive. Recently, algorithms to impute HLA genotype data using genome‐wide association study (GWAS) data have been published. However, imputation accuracy for most of these algorithms was based primarily on training data sets of European ancestry individuals. We considered performance of two HLA‐dedicated imputation algorithms – SNP2HLA and HIBAG – in a multiracial populati...
Source: International Journal of Immunogenetics - September 30, 2016 Category: Genetics & Stem Cells Authors: M. H. Kuniholm, X. Xie, K. Anastos, X. Xue, L. Reimers, A. L. French, S. J. Gange, S.  G. Kassaye, A. Kovacs, T. Wang, B. E. Aouizerat, H. D. Strickler Tags: Original Article Source Type: research

Association of tumour necrosis factor ‐alpha G/A ‐238 and G/A ‐308 single nucleotide polymorphisms with juvenile idiopathic arthritis
Summary Juvenile idiopathic arthritis (JIA) is a heterogeneous autoimmune disorder of unknown origin. As proinflammatory cytokines are known to contribute towards the pathogenesis of JIA, this case–control study was performed to examine the associations of certain single nucleotide polymorphisms (SNPs) of tumour necrosis factor‐α (TNF‐α) gene. Fifty‐three patients with JIA participated in this study as patients group and compared with 137 healthy unrelated controls. Genotyping was performed for TNF‐α gene at positions ‐308 and ‐238, using polymerase chain reaction with sequence‐specific primers method. R...
Source: International Journal of Immunogenetics - September 30, 2016 Category: Genetics & Stem Cells Authors: M. Maddah, S. Harsini, V. Ziaee, M. H. Moradinejad, A. Rezaei, S. Zoghi, M. Sadr, Y. Aghighi, N. Rezaei Tags: Original Article Source Type: research

Polymorphisms in Toll ‐like receptor 3 are associated with asthma‐related phenotypes in the Chinese Han patients
This study aimed to evaluate the effects of polymorphisms within TLR3 on asthma risk and asthma‐related phenotypes in the Chinese Han population. A total number of 462 unrelated adult patients with asthma and 398 healthy volunteers were enrolled in this study. The genotypes of tagging single nucleotide polymorphisms (SNPs) in TLR3 gene were determined using multiplex SNaPshot SNP genotyping assays. Case–control and case‐only studies were used to assess any links with asthma and asthma‐related phenotypes. The results showed that the genetic variants in TLR3 were associated with asthma‐related phenotypes, including...
Source: International Journal of Immunogenetics - September 29, 2016 Category: Genetics & Stem Cells Authors: Q. Zhang, X. L. Fu, F. H. Qian, Q. Cao, Z. D. Mao, J. L. Bai, Q. Du, Y. Shi Tags: Original Article Source Type: research