Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population
Summary Psoriasis is a chronic inflammatory skin disease occurred under the interaction of genetic and environmental factors. The genes HLA complex P5 (HCP5), spermatogenesis associated 2 (SPATA2), tumour necrosis factor alpha‐induced protein 3 (TNFAIP3), TNFAIP3‐interacting protein 1 (TNIP1) and the component of oligomeric Golgi complex 6 (COG6) were reported to be associated with psoriasis in western populations by genome‐wide association studies. The aim of this study was to investigate whether the HCP5, TNIP1, TNFAIP3, SPATA2 and COG6 genes were genetic risk factors for psoriasis in Chinese population. One single...
Source: International Journal of Immunogenetics - September 27, 2014 Category: Genetics & Stem Cells Authors: X.‐L. Li, H. Yu, G.‐S. Wu Tags: Original Article Source Type: research

Association study of MICA gene polymorphisms with rheumatoid arthritis susceptibility in south Tunisian population
This study indicates the involvement of the MICA‐250 polymorphism in the genetic susceptibility and severity to RA and suggests that variations in MICA‐TM and MICA met129 val may have an effect on RA severity in our south Tunisian sample. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - September 26, 2014 Category: Genetics & Stem Cells Authors: Y. Achour, A. Kammoun, M. Ben Hamad, N. Mahfoudh, S. Chaabane, S. Marzouk, L. Keskes, L. Gaddour, Z. Bahloul, A. Maalej Tags: Original Article Source Type: research

Association of the tumor necrosis factor ‐308 A/G promoter polymorphism with Tourette syndrome
Summary Several lines of evidence suggest that certain subtypes of obsessive‐compulsive and tic disorders might be paediatric manifestations of post‐streptococcal autoimmunity caused by cross‐reactive autoantibodies. As tumor necrosis factor (TNF) is known to play a seminal role in coordinating the humoral immune response, TNF gene polymorphisms have been proposed as genetic risk factors both in obsessive‐compulsive disorder (OCD) and Tourette syndrome (TS). The aim of this study was to investigate two TNF promoter polymorphisms (‐238 A/G: rs361525 and ‐308 A/G: rs1800629) on the genetic susceptibility to OCD a...
Source: International Journal of Immunogenetics - September 26, 2014 Category: Genetics & Stem Cells Authors: G. Keszler, E. Kruk, E. Kenezloi, Z. Tarnok, M. Sasvari‐Szekely, Z. Nemoda Tags: Original Article Source Type: research

Panacea or Pandora?
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - August 31, 2014 Category: Genetics & Stem Cells Authors: B. Clark Tags: Commentary Source Type: research

25th British Society for Histocompatibility and Immunogenetics Conference, Manchester, UK, 3rd and 4th September 2014
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - August 1, 2014 Category: Genetics & Stem Cells Tags: Abstract Source Type: research