International Journal of Immunogenetics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Three new HLA‐C alleles (HLA‐C*14:02:13, HLA‐C*15:72 and HLA‐C*15:74) in Saudi bone marrow donors
Summary Three new HLA‐C alleles were identified by sequence‐based typing method (SBT) in donors for the Saudi Bone Marrow Donor Registry (SBMDR). HLA‐C*14:02:13 differs from HLA‐C*14:02:01 by a silent G to A substitution at nucleotide position 400 in exon 2, where lysine at position 66 remains unchanged. HLA‐C*15:72 differs from HLA‐C*15:22 by a nonsynonymous C to A substitution at nucleotide position 796 in exon 3, resulting in an amino acid change from phenylalanine to leucine at position 116. HLA‐C*15:74 differs from HLA‐C*15:08 by a nonsynonymous C to T substitution at nucleotide position 914 in exon 3,...
Source: International Journal of Immunogenetics - August 1, 2015 Category: Genetics & Stem Cells Authors: H. A. Fakhoury, D. Jawdat, A. S. Alaskar, M. Al Jumah, N. Cereb, A. H. Hajeer Tags: Short Communication Source Type: research

Nomenclature for factors of the HLA system, update June 2015
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - August 1, 2015 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

Nomenclature for factors of the HLA system, update May 2015
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - August 1, 2015 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

Allele and haplotype frequencies of HLA‐A, B, C, DRB1 and DQB1 genes in polytransfused patients in ethnically diverse populations from Brazil
In conclusion, the HLA typing for polytransfused patients in each region has a great importance, as seen in this study; individuals from different regions from Brazil have HLA distribution not completely homogeneous. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - July 31, 2015 Category: Genetics & Stem Cells Authors: C. Rodrigues, L. C. Macedo, A. V. Bruder, F. d. C. Quintero, J. B. Alencar, A. M. Sell, J. E. L. Visentainer Tags: Population Study Source Type: research

Nomenclature for factors of the HLA system, update April 2015
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - July 31, 2015 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

Survey of genetic diversity of IgG in wild and domestic rabbits
Summary We sequenced IgG from genomic DNA of 30 wild European rabbits of O. c. algirus and O. c. cuniculus subspecies from three regions and 15 domestic O. c. cuniculus. Genetic diversity was highest within Iberian wild populations. Only two new amino acid polymorphisms were found, both in O. c. algirus. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - July 30, 2015 Category: Genetics & Stem Cells Authors: A. Pinheiro, T. Almeida, P. J. Esteves Tags: Short Communication Source Type: research

Computer‐aided design of T‐cell epitope‐based vaccines: addressing population coverage
This article reviews state‐of‐the‐art algorithms and computational tools to guide EV design through all the stages of the process: epitope prediction, epitope selection and vaccine assembly, while optimizing vaccine immunogenicity and coping with genetic variation in humans and pathogens. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - July 24, 2015 Category: Genetics & Stem Cells Authors: P. Oyarzun, B. Kobe Tags: Review Source Type: research

Human platelet antigen genotyping of platelet donors in southern Brazil
This study sought to determine the allele and genotype frequencies of HPA‐1, HPA‐2, HPA‐3, HPA‐4, HPA‐5 and HPA‐15 in platelet donors from the state of Rio Grande do Sul (RS), Brazil, and compare their allele frequencies to those observed in other populations. HPA genotyping was performed by PCR‐SSP method. The study sample comprised 201 platelet donors (167 Caucasians and 34 non‐Caucasians). Allele ‘a’ was that most commonly found for HPA‐1 to 5 in both groups. The HPA‐15ab genotype predominated over homozygous genotypes of this system. Fisher's exact test revealed statistically significant differe...
Source: International Journal of Immunogenetics - July 24, 2015 Category: Genetics & Stem Cells Authors: J. Merzoni, I. S. Fagundes, L. W. Lunardi, J. D.‐R. Lindenau, B. C. Gil, M. Jobim, V. G. Dias, L. Merzoni, L. Sekine, T. G. H. Onsten, L. F. Jobim Tags: Original Article Source Type: research

Identification of seven novel HLA class I alleles in New Zealand
Summary Seven new HLA class I alleles have been identified in the New Zealand population in the process of routine HLA typing and they are described here. Unusual bead positivity in Luminex typing identified potential new alleles in a bone marrow registry donor (B*40:285) and two HIV patients prior to abacavir prescription (B*14:02:09, B*41:29). In addition, four new class I alleles were identified through class I sequencing‐based typing (SBT) outside of exons 2 and 3. One mutation was identified in exon 4 (new allele C*12:125) and three have been found in exon 5, an exon rarely sequenced. Two stem cell transplant recipi...
Source: International Journal of Immunogenetics - July 24, 2015 Category: Genetics & Stem Cells Authors: G. Lamb, K.‐L. Choi, C. Selwyn, A. Wheeler, L. Hammond, J. Morgan, P. P. J. Dunn Tags: Short Communication Source Type: research

Corrigendum
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - July 7, 2015 Category: Genetics & Stem Cells Tags: Corrigendum Source Type: research

HLA class II susceptibility pattern for type 1 diabetes (T1D) in an Iranian population
This study aimed to determine the HLA‐DRB1/HLA‐DQB1 susceptibility and protection pattern for type 1 diabetes (T1D) in a population from Hamadan, north‐west of Iran. A total of 133 patients with T1D were tested for HLA‐DRB1 and HLA‐DQB1 alleles using PCR‐SSP compared to 100 ethnic‐matched healthy controls. Alleles and haplotypes frequencies were compared between both groups. The most susceptible alleles for disease were HLA‐DRB1*03:01, DRB1*04:02, DQB1*02:01 and DQB1*03:02, and protective alleles were HLA‐DRB1*07:01, *11:01, *13:01, *14:01 and DRB1*15 and HLA‐DQB1*06:01, *06:02 and *06:03. Haplotype ana...
Source: International Journal of Immunogenetics - June 18, 2015 Category: Genetics & Stem Cells Authors: J. Kiani, M. Hajilooi, D. Furst, H. Rezaei, S. Shahryari‐Hesami, S. Kowsarifard, A. Zamani, G. Solgi Tags: Original Article Source Type: research

Towards allele‐level human leucocyte antigens genotyping – assessing two next‐generation sequencing platforms: Ion Torrent Personal Genome Machine and Illumina MiSeq
Summary Human leucocyte antigens (HLA) typing has been a challenge due to extreme polymorphism of the HLA genes and limitations of the current technologies and protocols used for their characterization. Recently, next‐generation sequencing techniques have been shown to be a well‐suited technology for the complete characterization of the HLA genes. However, a comprehensive assessment of the different platforms for HLA typing, describing the limitations and advantages of each of them, has not been presented. We have compared the Ion Torrent Personal Genome Machine (PGM) and Illumina MiSeq, currently the two most frequent...
Source: International Journal of Immunogenetics - June 1, 2015 Category: Genetics & Stem Cells Authors: J. L. Duke, C. Lind, K. Mackiewicz, D. Ferriola, A. Papazoglou, O. Derbeneva, D. Wallace, D. S. Monos Tags: Original Article Source Type: research

Analysis of CCR5 and SDF‐1 genetic variants and HIV infection in Indian population
In this study, the SDF1‐3′A polymorphism, CCR5∆32 polymorphism and CCR5 promoter polymorphism at positions 58934 G/T, 59029 G/A, 59353 T/C, 59356 C/T, 59402 A/G and 59653 C/T were analysed in Indian population. The polymorphisms in HIV‐1 patients and healthy individuals were evaluated by conventional PCR, RFLP‐PCR and direct sequencing techniques. The CCR5∆32 mutant allele was found to be almost absent in Indian population. The analysis of the CCR5‐59356C/T polymorphism revealed a trend towards an association of the C allele with an increased risk of HIV‐1 infection. The frequency of allele CCR5‐59356C wa...
Source: International Journal of Immunogenetics - June 1, 2015 Category: Genetics & Stem Cells Authors: A. Gupta, Harish Padh Tags: Original Article Source Type: research

Genetics of common variable immunodeficiency: role of transmembrane activator and calcium modulator and cyclophilin ligand interactor
Summary Common variable immunodeficiency (CVID) is the most common clinically manifested primary immunodeficiency, which represents a heterogeneous group of hypogammaglobulinemias of largely unknown molecular defects. The hallmark of the disease is the elevated susceptibility to recurrent infections of respiratory and gastrointestinal tract, mainly due to encapsulated bacteria while a significant proportion of patients with CVID develop autoimmune and lymphoproliferative complications. The primary cause of CVID is still not known. However, a number of distinct genetic defects including in inducible co‐stimulator (ICOS), ...
Source: International Journal of Immunogenetics - June 1, 2015 Category: Genetics & Stem Cells Authors: H. D. Sathkumara, N. R. De Silva, S. Handunnetti, A. D. De Silva Tags: Review Source Type: research

Increased CD1D polymorphism: identification of two novel alleles, CD1D*03 and *04, in individuals from Morocco
Summary Two novel CD1D alleles were identified in unrelated individuals from Morocco. They differ each from the common CD1D*01 allele by one nucleotide substitution in exon 2 resulting in one amino acid change in the G‐ALPHA1‐LIKE domain. According to the IMGT unique numbering for G domain, CD1D*03 has one nucleotide transition c136 > t in codon 46, with an arginine‐to‐cysteine amino acid change (R46 > C) in the D‐STRAND, whereas CD1D*04 has one transition c98 > t in codon 33, with a threonine‐to‐methionine amino acid change (T33 > M) in the C‐STRAND. This suggests that CD1D is more polymorphic ...
Source: International Journal of Immunogenetics - June 1, 2015 Category: Genetics & Stem Cells Authors: A. Aureli, K. Oumhani, T. Del Beato, M. Di Rocco, A. Tessitore, R. El Aouad, D. Piancatelli Tags: Short Communication Source Type: research