International Journal of Immunogenetics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Genetic association of interleukin‐2, interleukin‐4, interleukin‐6, transforming growth factor‐β, tumour necrosis factor‐α and blood concentrations of calcineurin inhibitors in Turkish renal transplant patients
Summary Cytokines are essential for the control of the immune response as most of the immunosuppressive drugs target cytokine production or their action. The calcineurin inhibitors (CNIs) cyclosporine (CsA) and tacrolimus are immunosuppressive drugs widely used after renal transplantation to prevent allograft rejection. They are characterized by large interindividual variability in their pharmacokinetics; therefore, monitoring their blood concentrations is important to predict their optimal dosage following transplantation. Calcineurin inhibitors inhibit the phosphatase activity of calcineurin, thereby suppressing the prod...
Source: International Journal of Immunogenetics - March 26, 2015 Category: Genetics & Stem Cells Authors: Y. Seyhun, H. S. Ciftci, C. Kekik, M. S. Karadeniz, T. Tefik, I. Nane, A. Turkmen, F. S. Oguz, F. Aydin Tags: Original Article Source Type: research

Wild boars from Sweden, Austria, the Czech Republic and Japan possess intact mannose‐binding lectin 2 (MBL2) genes
Summary The two‐nucleotide deletion recently detected in the mannose‐binding lectin 2 gene in purebred and crossbred domestic pigs was not found among 68 wild boars representing 4 populations from Europe and Asia. This suggests that the deletion is a result of breeding and/or genetic drift/bottle necks. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - March 25, 2015 Category: Genetics & Stem Cells Authors: I. M. Bergman, N. Okumura, H. Uenishi, S. E. Hammer, A. Knoll, I. Edfors, H. R. Juul‐Madsen Tags: Short Communication Source Type: research

Imputation of class I and II HLA loci using high‐density SNPs from ImmunoChip and their associations with Kawasaki disease in family‐based study
Summary Kawasaki disease (KD) is the leading cause of acquired heart disease in children in most developed countries including the United States. The etiology of KD is not known; however, epidemiological and immunological data suggest infectious or immune‐related factors in the manifestation of the disease. Further, KD has several hereditary features that strongly suggest a genetic component to disease pathogenesis. Human leucocyte antigen (HLA) loci have also been reported to be associated with KD, but results have been inconsistent, in part, because of small study samples and varying linkage disequilibrium (LD) pattern...
Source: International Journal of Immunogenetics - March 24, 2015 Category: Genetics & Stem Cells Authors: S. Shrestha, H. W. Wiener, B. Aissani, A. Shendre, J. Tang, M. A. Portman Tags: Original Article Source Type: research

Distribution of cytokine gene polymorphisms in five Malay subethnic groups in Peninsular Malaysia
Summary In this survey, we have successfully genotyped 22 single nucleotide polymorphisms in the 13 cytokine genes for five Malay subethnic groups (Kelantan, Acheh, Mandailing, Minangkabau and Patani Malays) using polymerase chain reaction–sequence‐specific primer cytokine genotyping kit (Invitrogen, Carlsbad, CA, USA). Most of the cytokine genes showed similar pattern of allelic spectra with wild‐type alleles (e.g. ILIa−889/C, ILIB+3962/C and IL6 nt565/G) that represent more than 80% in the studied Malay subethnic groups. These newly observed cytokine alleles and subsequent analyses clearly indicate genetic contri...
Source: International Journal of Immunogenetics - March 22, 2015 Category: Genetics & Stem Cells Authors: H. K. Norhalifah, Z. Zafarina, P. Sundararajulu, M. N. Norazmi, H. A. Edinur Tags: Short Communication Source Type: research

Corrigendum
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - March 10, 2015 Category: Genetics & Stem Cells Tags: Corrigendum Source Type: research

Meeting report: 3rd international transplant conference: how much risk can you take?
Summary The 3rd International Transplant Conference took place on 31st October and 1st November 2014 at the University of Warwick, Coventry, UK. Key focal points of the meeting were the exploration of the molecular basis of antibody–antigen interactions and their relation to clinical practice and to share experiences and knowledge regarding strategies to transplant the ‘high‐risk’ patient. In addition, lively debate sessions were hosted where controversial clinical and immunological themes were discussed by leading experts in the field. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - February 12, 2015 Category: Genetics & Stem Cells Authors: D. Lowe, S. Daga, D. Briggs, N. Khovanova, D. Mitchell, R. Higgins, N. Krishnan Tags: Meeting Report Source Type: research

Association of TNFAIP3 and TNFRSF1A variation with multiple sclerosis in a German case–control cohort
In conclusion, evidence is accumulating that polymorphisms in both TNFAIP3 and TNFRSF1A genes play a role in MS pathogenesis. Additional studies are warranted to further elucidate the role of TNF pathway variation for MS development. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - February 12, 2015 Category: Genetics & Stem Cells Authors: S. Hoffjan, A. Okur, J. T. Epplen, S. Wieczorek, A. Chan, D. A. Akkad Tags: Original Article Source Type: research

Nomenclature for factors of the HLA system, update October 2014
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - February 5, 2015 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

Nomenclature for factors of the HLA system, update December 2014
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - February 5, 2015 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

Relationship between programmed cell death‐1 polymorphisms and clearance of hepatitis B virus
This study investigated the relationship between the polymorphisms of PD‐1 gene and the susceptibility to HBV infection. Single nucleotide polymorphisms (SNPs) in PD‐1 gene at positions +7146 G>A (guanine to adenine substitution) and +7209 C>T (cytosine to thymine substitution) were analysed using a polymerase chain reaction–restriction fragment length polymorphism (PCR‐RFLP) method in 220 subjects with chronic hepatitis B infection and 165 spontaneous clearance of HBV subjects. However, no statistically significant differences were found in the genotype distributions of the PD‐1 +7146 G>A and PD‐1 +72...
Source: International Journal of Immunogenetics - February 1, 2015 Category: Genetics & Stem Cells Authors: Y. Ülger, S. Bayram, M. Ü. Sandıkçı, E. Akgöllü, A. Bekar Tags: Original Article Source Type: research

Association between polymorphisms of the swine MHC‐DQA gene and diarrhoea in three Chinese native piglets
Summary Swine leucocyte antigen (SLA) is a highly polymorphic multigene family that plays a crucial role in swine immune response and disease resistance. Here, we identified polymorphisms and gene variations of SLA‐DQA exon 2 using polymerase chain reaction–single‐strand conformation polymorphism (PCR‐SSCP) and DNA sequencing analysis, and further investigated the correlation between the polymorphisms and piglet diarrhoea in three Chinese native pig breeds (Bamei, Juema and Gansu Black pigs). Consequently, 12 genotypes and 8 alleles including two novel alleles were detected. Nucleotide polymorphism was compared wit...
Source: International Journal of Immunogenetics - February 1, 2015 Category: Genetics & Stem Cells Authors: L. X. Liu, S. G. Zhao, H. N. Lu, Q. L. Yang, X. Y. Huang, S. B. Gun Tags: Original Article Source Type: research

Frequency of P2RX7 A1513C and TLR2 −196 to −174 ins/del in healthy Polish individuals
Summary Polymorphisms within genes coding innate immune response proteins are involved in genetic susceptibility to various conditions. We investigated the frequency of P2RX7 A1513C and TLR2 −196 to −174 ins/del polymorphisms in healthy Polish population. Frequency of minor alleles was relatively similar to the pattern presented by Caucasian populations while it differed significantly when compared to non‐European populations, which could be a result of variable selection pressure put upon studied alleles or hindered gene flow between populations. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - February 1, 2015 Category: Genetics & Stem Cells Authors: M. Lewandowska, P. Garczyńska, K. Jędrychowska‐Dańska, P. Kopczyńska, A. Masłowska, H. Witas Tags: Short Communication Source Type: research

The association of CTLA‐4 A49G polymorphism with colorectal cancer risk in a Chinese Han population
In conclusion, we demonstrated that the CTLA‐4 A49G polymorphism increased the susceptibility of colorectal cancer in Asian population. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - February 1, 2015 Category: Genetics & Stem Cells Authors: Y. Wang, X. Wang, R. Zhao Tags: Original Article Source Type: research

Role of the functional MNS16A VNTR‐243 variant of the human telomerase reverse transcriptase gene in progression and response to therapy of patients with non‐Hodgkin's B‐cell lymphomas
Summary MNS16A is a functional polymorphic tandem repeat within the human telomerase reverse transcriptase (hTERT) gene. To investigate whether any of the MNS16A repeats represents a genetic risk factor for NHL susceptibility, progression of or response to therapy in 75 patients with non‐Hodgkin's lymphomas (NHLs) and 126 healthy individuals were genotyped using the PCR‐VNTR technique. A slightly higher frequency of the MNS16A VNTR‐243 variant was detected among patients who did not respond to treatment (NR) as compared to patients with complete or partial remission (0.83 vs. 0.51, P = 0.055). NR patients more freq...
Source: International Journal of Immunogenetics - February 1, 2015 Category: Genetics & Stem Cells Authors: B. Wysoczanska, T. Wrobel, O. Dobrzynska, G. Mazur, K. Bogunia‐Kubik Tags: Original Article Source Type: research

Nomenclature for factors of the HLA system, update November 2014
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - February 1, 2015 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research