International Journal of Immunogenetics International Journal of Immunogenetics RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Identification of a new HLA ‐G allele, HLA‐G*01:19, by cloning and phasing
Summary A new HLA‐G allelic variant, HLA‐G*01:19, was identified in a southern Chinese Han population by polymerase chain reaction–sequence‐based typing (PCR‐SBT), cloning and phasing. HLA‐G*01:19 differs from HLA‐G*01:04:01 by a nonsynonymous cytosine at position 99 in exon 2, resulting in amino acid change from valine to leucine at codon 34 of the mature HLA‐G molecule. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - June 8, 2016 Category: Genetics & Stem Cells Authors: W. Y. Wang, W. Tian Tags: Short Communication Source Type: research

Killer ‐cell immunoglobulin‐like receptors and cytomegalovirus reactivation during late pregnancy
In this study, we set out to determine whether a protective effect of KIR genes over CMV infection is seen in Mexican pregnant women. Cytomegalovirus infection was assessed through nucleic acid testing in 200 pregnant women and 600 healthy blood donors comprising the Mexican mestizo reference population. Killer‐cell immunoglobulin‐like receptors and HLA‐C genotypes were obtained from 200 pregnant women and 300 reference samples using a comprehensive PCR‐SSP approach. We observed statistically lower carrier frequencies of cB03|tA01 gene‐content haplotype, of cB03 haplotype motif, of the KIR2DL5 + 2DS3/2DS5 gene ...
Source: International Journal of Immunogenetics - June 8, 2016 Category: Genetics & Stem Cells Authors: D. L. Alvarado ‐Hernández, A. Benítez‐Sánchez, J. S. Rodríguez‐Cuevas, T. Rosales‐Saavedra, S. E. Guerra‐Palomares, A. Comas‐García, D. E. Noyola, C. A. García‐Sepúlveda Tags: Original Article Source Type: research

Identification of a new HLA‐G allele, HLA‐G*01:19, by cloning and phasing
Summary A new HLA‐G allelic variant, HLA‐G*01:19, was identified in a southern Chinese Han population by polymerase chain reaction–sequence‐based typing (PCR‐SBT), cloning and phasing. HLA‐G*01:19 differs from HLA‐G*01:04:01 by a nonsynonymous cytosine at position 99 in exon 2, resulting in amino acid change from valine to leucine at codon 34 of the mature HLA‐G molecule. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - June 8, 2016 Category: Genetics & Stem Cells Authors: W. Y. Wang, W. Tian Tags: Short Communication Source Type: research

A novel HLA ‐B allele, HLA‐B*35:279, identified by sequencing‐based typing in a Czech patient
Summary The identification of a novel HLA‐B*35:279 allele in a Czech patient is described. This allele is identical to the B*35:03:01 variant except the G/A nucleotide exchange at position 652 of the HLA‐B gene that corresponds to the amino acid substitution from valine to isoleucine in alpha 3 domain of the HLA‐B antigen. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - June 7, 2016 Category: Genetics & Stem Cells Authors: F. Mrazek, J. Onderkova, N. K önigova, V. Siffnerova, M. Vrana, Z. Ambruzova, I. Skoumalova, M. Petrek, L. Raida Tags: Short Communication Source Type: research

Characterization of a novel HLA ‐B*40 allele, HLA‐B*40:186:02, by cloning and sequencing
Summary A novel HLA‐B*40 variant, HLA‐B*40:186:02, has been identified by cloning and sequencing in a southern Chinese Han population. Aligned with HLA‐B*40:01:01, HLA‐B*40:186:02 has a nonsynonymous cytosine mutation at nucleotide position 165 in exon 2, leading to amino acid change from glycine to arginine at codon 56. It differs from HLA‐B*40:186:01 by a synonymous change (adenine to cytosine) at position 165 in exon 2. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - June 7, 2016 Category: Genetics & Stem Cells Authors: W. Y. Wang, W. Zhang, J. H. Cai, F. M. Zhu, W. Tian Tags: Short Communication Source Type: research

Characterization of a novel MICA allele, MICA*012:05, by cloning and sequencing
Summary A new MICA allelic variant, MICA*012:05, has been identified in a Chinese Mongolian population. Following polymerase chain reaction–sequence‐based typing (PCR‐SBT), this new allele was further confirmed by cloning and sequencing. MICA*012:05 was linked to an HLA‐A*24‐C*01‐B*55:02‐DRB1*09 haplotype. MICA*012:05 differs from MICA*012:01 by a single synonymous C to T substitution at nucleotide position 269 in exon 3. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - June 7, 2016 Category: Genetics & Stem Cells Authors: W. Y. Wang, W. Tian, F. Wang, F. M. Zhu, L. X. Li Tags: Short Communication Source Type: research

Characterization of a novel HLA‐B*40 allele, HLA‐B*40:186:02, by cloning and sequencing
Summary A novel HLA‐B*40 variant, HLA‐B*40:186:02, has been identified by cloning and sequencing in a southern Chinese Han population. Aligned with HLA‐B*40:01:01, HLA‐B*40:186:02 has a nonsynonymous cytosine mutation at nucleotide position 165 in exon 2, leading to amino acid change from glycine to arginine at codon 56. It differs from HLA‐B*40:186:01 by a synonymous change (adenine to cytosine) at position 165 in exon 2. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - June 7, 2016 Category: Genetics & Stem Cells Authors: W. Y. Wang, W. Zhang, J. H. Cai, F. M. Zhu, W. Tian Tags: Short Communication Source Type: research

Frequencies of red blood cell major blood group antigens and phenotypes in the Chinese Han population from Mainland China
This study systematically describes the frequencies of 24 blood group antigens in the Chinese Han population from Mainland China. The data can be helpful in creating a donor database for preparation of indigenous cell panels and providing antigen‐negative blood to patients with multiple alloantibodies. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - May 31, 2016 Category: Genetics & Stem Cells Authors: Y. Yu, C. Ma, X. Sun, X. Guan, X. Zhang, J. Saldanha, L. Chen, D. Wang Tags: Original Article Source Type: research

Polymorphism in the chemokine receptor 7 gene (CCR7) is associated with previous myocardial infarction in patients undergoing elective coronary angiography
Summary Coronary artery disease (CAD) remains a major cause of death in developed countries. Both environmental and, less known, genetic factors contribute to progression of CAD to myocardial infarction (MI). Immune system is activated in patients with CAD through dendritic cells (DCs), which present plaque antigens to T lymphocytes. Production of proinflammatory cytokines by activated T cells contributes to plaque rupture in MI. Chemokine receptor 7 (CCR7) on DCs is required for their chemotaxis from plaque to lymph nodes. This makes possible an interaction of DCs with T lymphocytes and initiation of specific immune respo...
Source: International Journal of Immunogenetics - May 31, 2016 Category: Genetics & Stem Cells Authors: P. P. Wołkow, L. Drabik, J. Totoń‐Żurańska, K. Kuś, J. Foryś, A. Słowik, J. Pera, J. Godlewski, M. Tomala, K. Żmudka, R. Olszanecki, J. Jawień, R. Korbut Tags: Original Article Source Type: research

A novel HLA‐B*14 allele – B*14:53 – genetics and serology
Summary HLA‐B*14:53 was found in a UK European normal blood donor prior to registration on the Welsh Bone Marrow Donor Registry. It differs from B*14:13 by one base (103G>T) in exon 2 resulting in a substitution of alanine (A) in B*14:13 to serine (S) in B*14:53. Unique among current HLA‐B*14 alleles, B*14:53 and B*14:13 share a motif of 59 bases between positions 361 and 419 in exon 3. This motif is present in numerous HLA‐B alleles the commonest overall being B*08:01, suggesting that both B*14:53 and B*14:13 arose from intralocus gene conversion events with B*08:01. Thus, B*14:53 probably arose from B*14:01:01 (...
Source: International Journal of Immunogenetics - May 31, 2016 Category: Genetics & Stem Cells Authors: J. Street, E. Davies, C. Darke Tags: Original Article Source Type: research

The common gamma chain cytokine interleukin‐21 is expressed by activated lymphocytes from two macropod marsupials, Macropus eugenii and Onychogalea fraenata
Summary In mammals, interleukin‐21 is a member of the common gamma chain cytokine family that also includes IL‐2, IL‐4, IL‐7, IL‐9 and IL‐15. IL‐21 has pleiotropic effects on both myeloid and lymphoid immune cells and as a consequence, the biological actions of IL‐21 are broad: regulating both innate and adaptive immune responses and playing a pivotal role in antiviral, inflammatory and antitumour cellular responses. While IL‐21 genes have been characterized in mammals, birds, fish and amphibians, there are no reports for any marsupial species to date. We characterized the expressed IL‐21 gene from immu...
Source: International Journal of Immunogenetics - May 31, 2016 Category: Genetics & Stem Cells Authors: A. N. Suthers, J. M. Old, L. J. Young Tags: Original Article Source Type: research

A novel HLA‐B*40 allele, B*40:01:40, identified in a Chinese individual
Summary A new allele, officially named B*40:01:40, was detected in a Chinese individual by sequence‐based typing (SBT). The new allele differs from B*40:01:01 by a single nucleotide exchange at position 99 in codon 9, which results in synonymous substitution and seems not to compromise the HLA complex and T‐cell receptor interaction. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - May 31, 2016 Category: Genetics & Stem Cells Authors: Y. F. Pei, H. N. Huang, H. C. Li, W. D. Shen Tags: Short Communication Source Type: research

Killer‐cell immunoglobulin‐like receptors and cytomegalovirus reactivation during late pregnancy
In this study, we set out to determine whether a protective effect of KIR genes over CMV infection is seen in Mexican pregnant women. Cytomegalovirus infection was assessed through nucleic acid testing in 200 pregnant women and 600 healthy blood donors comprising the Mexican mestizo reference population. Killer‐cell immunoglobulin‐like receptors and HLA‐C genotypes were obtained from 200 pregnant women and 300 reference samples using a comprehensive PCR‐SSP approach. We observed statistically lower carrier frequencies of cB03|tA01 gene‐content haplotype, of cB03 haplotype motif, of the KIR2DL5 + 2DS3/2DS5 gene ...
Source: International Journal of Immunogenetics - May 31, 2016 Category: Genetics & Stem Cells Authors: D. L. Alvarado‐Hernández, A. Benítez‐Sánchez, J. S. Rodríguez‐Cuevas, T. Rosales‐Saavedra, S. E. Guerra‐Palomares, A. Comas‐García, D. E. Noyola, C. A. García‐Sepúlveda Tags: Original Article Source Type: research

A novel HLA‐B allele, HLA‐B*35:279, identified by sequencing‐based typing in a Czech patient
Summary The identification of a novel HLA‐B*35:279 allele in a Czech patient is described. This allele is identical to the B*35:03:01 variant except the G/A nucleotide exchange at position 652 of the HLA‐B gene that corresponds to the amino acid substitution from valine to isoleucine in alpha 3 domain of the HLA‐B antigen. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - May 31, 2016 Category: Genetics & Stem Cells Authors: F. Mrazek, J. Onderkova, N. Königova, V. Siffnerova, M. Vrana, Z. Ambruzova, I. Skoumalova, M. Petrek, L. Raida Tags: Short Communication Source Type: research

Nomenclature for factors of the HLA system, update March 2016
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - May 3, 2016 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research