Characterization of a novel HLA ‐B*40 allele, HLA‐B*40:186:02, by cloning and sequencing

Summary
A novel HLA‐B*40 variant, HLA‐B*40:186:02, has been identified by cloning and sequencing in a southern Chinese Han population. Aligned with HLA‐B*40:01:01, HLA‐B*40:186:02 has a nonsynonymous cytosine mutation at nucleotide position 165 in exon 2, leading to amino acid change from glycine to arginine at codon 56. It differs from HLA‐B*40:186:01 by a synonymous change (adenine to cytosine) at position 165 in exon 2.

Source: International Journal of Immunogenetics - June 7, 2016 Category: Genetics & Stem Cells Authors: W. Y. Wang, W. Zhang, J. H. Cai, F. M. Zhu, W. Tian Tags: Short Communication Source Type: research