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Nomenclature for factors of the HLA system, update March 2017
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - May 15, 2017 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: NOMENCLATURE Source Type: research

Polymorphisms in the promoter region of iNOS predispose to rheumatoid arthritis in south Indian Tamils
Summary Nitric oxide synthase (NOS) catalyses the production of nitric oxide (NO) from L‐Arginine, which participates in diverse biological processes including inflammation and apoptosis. Macrophages, chondrocytes, osteoblasts and osteoclasts express inducible NOS (iNOS) at the site of synovial inflammation. NO produced at the inflamed joint may contribute to peri‐articular bone loss, mediate apoptosis and regulate Th1/Th2 balance in rheumatoid arthritis (RA). Variations in the promoter region of NOS gene regulate the nitric oxide synthase expression and iNOS (NOS2) polymorphisms have been associated with susceptibilit...
Source: International Journal of Immunogenetics - April 4, 2017 Category: Genetics & Stem Cells Authors: V. S. Negi, C. M. Mariaselvam, D. P. Misra, N. Muralidharan, C. Fortier, D. Charron, R. Krishnamoorthy, R. Tamouza Tags: ORIGINAL ARTICLE Source Type: research

Vitamin D receptor gene polymorphisms association with the risk of sepsis and mortality
Summary Association of vitamin D receptor (VDR) gene polymorphisms with sepsis risk and mortality was studied. VDR FokI CC genotype was associated with increased sepsis risk (OR = 13.396, p = .000009) compared to the TT genotype. Results suggest possible role of VDR FokI (rs2228570) as a molecular biomarker of increased sepsis risk. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - April 1, 2017 Category: Genetics & Stem Cells Authors: K. Zeljic, A. Elkilany, G. Supic, M. Surbatovic, D. Djordjevic, Z. Magic, B. Bozic Tags: SHORT COMMUNICATION Source Type: research

Characterization of three new HLA Class I Alleles in Spanish Caucasians, HLA ‐A*02:620, HLA‐B*27:150 and HLA‐B*07:05:01:02
Summary Three new HLA class I alleles, HLA‐A*02:620, HLA‐B*27:150 and HLA‐B*07:05:01:02, were described in the Spanish Caucasoid population. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - April 1, 2017 Category: Genetics & Stem Cells Authors: A. Balas, D. Planelles, P. Montesinos, C. Solano, J. L. Vicario Tags: SHORT COMMUNICATION Source Type: research

Immunogenetic profiling of 23 SNPs of cytokine and chemokine receptor genes through a minisequencing technique: Design, development and validation
Summary The minisequencing technique offers accuracy and robustness to genotyping of polymorphic DNA variants, being an excellent option for the identification and analyses of prognostic/susceptibility markers in human diseases. Two multiplex minisequencing assays were designed and standardized to screen 23 candidate SNPs in cytokine, chemokine receptor and ligand genes previously associated with susceptibility to cancer and autoimmune disorders as well as to infectious diseases outcome. The SNPs were displayed in two separate panels (panel 1—IL2 rs2069762, TNFα rs1800629, rs361525; IL4 rs2243250; IL6 rs1800795; IL10 rs...
Source: International Journal of Immunogenetics - April 1, 2017 Category: Genetics & Stem Cells Authors: J. M. Valverde ‐Villegas, R. M. Medeiros, S. E. M. Almeida, J. A. B. Chies Tags: ORIGINAL ARTICLE Source Type: research

New genes associated with rheumatoid arthritis identified by gene expression profiling
In this study, we aimed to find new genes associated with rheumatoid arthritis (RA) so that more comprehensive genes would be used for monitoring and/or diagnosing patients. Illumina digital gene expression profiling was applied in two sample types – peripheral blood mononuclear cells (PBMCs) and synovial cells to compare the gene expression pattern between 17 patients with RA and three control groups (six osteoarthritis patients, three ankylosing spondylitis patients and 17 healthy controls). Bioinformatics was performed on pathway analysis and protein–protein interaction networks. Four novel genes from PBMCs – DHRS...
Source: International Journal of Immunogenetics - April 1, 2017 Category: Genetics & Stem Cells Authors: H. Wang, J. Guo, J. Jiang, W. Wu, X. Chang, H. Zhou, Z. Li, J. Zhao Tags: ORIGINAL ARTICLE Source Type: research

Promoter polymorphisms of the TIM ‐4 gene are correlated with disease activity in patients with systemic lupus erythematosus
This study aimed to investigate the association of two TIM‐4 single nucleotide polymorphisms (SNPs) rs6874202 (−1419G>A) and rs62382402 (−1609G>A) with SLE susceptibility in a Chinese Han population. The results showed no significant differences between patients with SLE and control group for rs6874202 and rs62382402 (p = .72, .53 respectively). However, the anti‐dsDNA levels in serum from SLE patients with GG genotype of TIM‐4 gene at ‐1419 site were significantly higher than those with GA and AA genotype (p = .0335), and C3 levels of SLE patients with GG and GA genotype were much lower than those wi...
Source: International Journal of Immunogenetics - April 1, 2017 Category: Genetics & Stem Cells Authors: B. Liu, W. Liu, R. Wang, Q. Shu, X. Zhang, X. Fan, Q. Zhang, X. Liang, C. Ma, L. Gao Tags: ORIGINAL ARTICLE Source Type: research

Genetic susceptibility to severe asthma with fungal sensitization
Summary Severe asthma is problematic and its pathogenesis poorly understood. Fungal sensitization is common, and many patients with severe asthma with fungal sensitization (SAFS), used to denote this subgroup of asthma, respond to antifungal therapy. We have investigated 325 haplotype‐tagging SNPs in 22 candidate genes previously associated with aspergillosis in patients with SAFS, with comparisons in atopic asthmatics and healthy control patients, of whom 47 SAFS, 279 healthy and 152 atopic asthmatic subjects were genotyped successfully. Significant associations with SAFS compared with atopic asthma included Toll‐like...
Source: International Journal of Immunogenetics - March 31, 2017 Category: Genetics & Stem Cells Authors: N. L. Overton, A. Simpson, P. Bowyer, D. W. Denning Tags: ORIGINAL ARTICLE Source Type: research

A new MICA allele, MICA*007:07, characterized by cloning and sequencing
Summary A new MICA allelic variant, MICA*007:07, was identified in an individual of Mongol ethnicity in the Inner Mongolia Autonomous Region, northern China. Following polymerase chain reaction‐sequence‐based typing (PCR‐SBT), this new allele was further confirmed by cloning and sequencing. MICA*007:07 differs from MICA*007:01 by a synonymous mutation from G to A at the 2nd nucleotide position in exon 2. MICA*007:07 was linked to HLA‐B*27:05. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - March 29, 2017 Category: Genetics & Stem Cells Authors: W. Y. Wang, W. Tian, F. Wang, F. M. Zhu, P. X. Wang, L. F. Xing Tags: SHORT COMMUNICATION Source Type: research

IL33 and IL1RL1 variants are associated with asthma and atopy in a Brazilian population
Summary Atopic asthma is a chronic inflammatory disease in airways resulting from genetic and environmental factors, characterized by production of the Th2 cytokines interleukin‐4 (IL‐4), interleukin‐5 (IL‐5) and interleukin‐13 (IL‐13). Interleukin‐33 (IL‐33) appears to be a potent inducer of Th2 immune response. This occurs when IL‐33 binds and activates its receptor, the membrane ST2 (ST2L) in mast cells, dendritic cells, basophils, eosinophils, innate lymphoids and Th2 cells, leading to the release of these cytokines and intensifying allergic inflammation. Polymorphisms in the IL33 and IL1RL1 can act a...
Source: International Journal of Immunogenetics - March 6, 2017 Category: Genetics & Stem Cells Authors: G. A. Queiroz, R. S. Costa, N. M. Alcantara ‐Neves, G. Nunes de Oliveira Costa, M. L. Barreto, V. L. Carneiro, C. A. Figueiredo Tags: Original Article Source Type: research

Nomenclature for factors of the HLA system, update October 2016
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - February 7, 2017 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

Nomenclature for factors of the HLA system, update November 2016
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - January 31, 2017 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

A functional variant of miRNA ‐149 confers risk for allergic rhinitis and comorbid asthma in Chinese children
Summary The prevalence of allergic rhinitis (AR) and asthma has been increasing, and the comorbidity rates of these diseases are very high. Here, 176 AR patients, 124 patients with comorbid AR and asthma (AR‐A) and 206 healthy Chinese children as controls were included in a case–control study. Six single‐nucleotide polymorphisms (SNPs), miR‐146a (rs2910164, rs57095329 and rs6864584), miR‐196a2 (rs11614913), miR‐499 (rs3746444) and miR‐149 (rs2292832), were genotyped. The prevalence of homozygous miR‐149 (rs2292832) CC genotype and C allele were considerably increased in AR and AR‐A patients, compared wi...
Source: International Journal of Immunogenetics - January 31, 2017 Category: Genetics & Stem Cells Authors: D. Hu, Z. Zhang, X. Ke, H. Kang, S. Hong Tags: Original Article Source Type: research

Nomenclature for factors of the HLA system, update December 2016
(Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - January 31, 2017 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

The IL15 +96522 A > T functional polymorphism is related to the differentiation of Th17 cells and the severity of Hashimoto's disease
Summary To clarify the association between the genetic producibility of IL‐15, a pro‐inflammatory cytokine, and the pathogenesis of autoimmune thyroid diseases (AITDs), we genotyped +96522 A>T and +82889 A>G polymorphisms in the IL15 gene using 127 patients with Hashimoto's disease (HD), including 55 patients with severe HD and 48 patients with mild HD; 130 patients with Graves’ disease (GD), including 52 patients with intractable GD and 44 patients with GD in remission; and 79 healthy volunteers. Both the IL15 +96522 A allele and AA genotype were more frequent in patients with severe HD than in those with mild...
Source: International Journal of Immunogenetics - January 31, 2017 Category: Genetics & Stem Cells Authors: Y. Arakawa, M. Watanabe, K. Takemura, N. Inoue, Y. Hidaka, Y. Iwatani Tags: Original Article Source Type: research