Three new HLA‐C alleles (HLA‐C*14:02:13, HLA‐C*15:72 and HLA‐C*15:74) in Saudi bone marrow donors
Summary
Three new HLA‐C alleles were identified by sequence‐based typing method (SBT) in donors for the Saudi Bone Marrow Donor Registry (SBMDR). HLA‐C*14:02:13 differs from HLA‐C*14:02:01 by a silent G to A substitution at nucleotide position 400 in exon 2, where lysine at position 66 remains unchanged. HLA‐C*15:72 differs from HLA‐C*15:22 by a nonsynonymous C to A substitution at nucleotide position 796 in exon 3, resulting in an amino acid change from phenylalanine to leucine at position 116. HLA‐C*15:74 differs from HLA‐C*15:08 by a nonsynonymous C to T substitution at nucleotide position 914 in exon 3, resulting in an amino acid change from arginine to tryptophan at position 156.
Source: International Journal of Immunogenetics - Category: Genetics & Stem Cells Authors: H. A. Fakhoury, D. Jawdat, A. S. Alaskar, M. Al Jumah, N. Cereb, A. H. Hajeer Tags: Short Communication Source Type: research
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