Increased CD1D polymorphism: identification of two novel alleles, CD1D*03 and *04, in individuals from Morocco

Summary Two novel CD1D alleles were identified in unrelated individuals from Morocco. They differ each from the common CD1D*01 allele by one nucleotide substitution in exon 2 resulting in one amino acid change in the G‐ALPHA1‐LIKE domain. According to the IMGT unique numbering for G domain, CD1D*03 has one nucleotide transition c136 > t in codon 46, with an arginine‐to‐cysteine amino acid change (R46 > C) in the D‐STRAND, whereas CD1D*04 has one transition c98 > t in codon 33, with a threonine‐to‐methionine amino acid change (T33 > M) in the C‐STRAND. This suggests that CD1D is more polymorphic than previously assumed.
Source: International Journal of Immunogenetics - Category: Genetics & Stem Cells Authors: Tags: Short Communication Source Type: research