Identification and characterization a novel HLA ‐A allele, A*02:355, by sequence‐based typing in a Chinese potential donor

Summary
The new allele A*02:355 differs from A* 02:03:01 at positions 98 (T→A) and 102(A→C) resulting in an amino acid exchange F9→T. Interallelic sequence exchange is more likely the mechanism of its origination. The amino acid replacement influences the HLA peptide binding cleft and might have significant functional effects.

Source: International Journal of Immunogenetics - January 1, 2017 Category: Genetics & Stem Cells Authors: X ‐M. Nie, Y. Zhang, W‐B. Qiao, C‐F. Zhu, Y‐R. Zhao Tags: Short Communication Source Type: research