HLA‐G 14‐bp polymorphism affects the age of onset in Type I Diabetes Mellitus

This study investigates the involvement of a 14‐bp deletion polymorphism (rs371194629) at the 3′ untranslated region of HLA‐G in the context of T1DM and age of onset. The frequency of the polymorphism was determined in unrelated T1DM Cypriot patients and findings that emerge from this study show a strong association between the HLA‐G 14‐bp polymorphism and T1DM with respect to the age of onset. Specifically, the deletion/deletion (DEL/DEL) genotype was found to be associated with an early age of onset (P = 0.001), while the presence of the insertion allele (INS) was associated to a later age of onset (P = 0.0001), portraying a possible dominant effect over the deletion allele, a role in delaying disease onset and an overall involvement of HLA‐G in the pathogenesis of type I diabetes mellitus.
Source: International Journal of Immunogenetics - Category: Genetics & Stem Cells Authors: Tags: Original Article Source Type: research