Prediction and preliminary screening of HLA‐A*0201‐restricted epitope peptides of human GPC3

In this study, potential HLA‐A*0201 GPC3 peptides were screened with three epitope prediction software, the binding affinity of 13 predicted epitopes with high scores was determined by T2 cells binding assay and four optimal epitopes were identified. This is the first study in which the optimal HLA‐A*0201 GPC3 epitopes were screened from a large number of candidates predicted by three software. The optimized HLA‐A*0201 GPC3 peptides will provide new epitope candidates for HCC immunotherapy.
Source: International Journal of Immunogenetics - Category: Genetics & Stem Cells Authors: Tags: Original Article Source Type: research