Genotype frequencies of human neutrophil antigen ‐3 in the Chinese Zhuang and Dong populations

This study showed Chinese Zhuang and Dong populations possessed a higher frequency of HNA‐3b/3b genotype, suggesting that they may be at greater risk for developing anti‐HNA‐3a alloantibodies that may cause severe cases of TRALI. A molecular‐based identification of the HNA‐3b/3b genotype in all multiparous female blood donors was suggested to reduce the risk of TRALI following plasma and whole blood allogeneic transfusions.

Source: International Journal of Immunogenetics - October 1, 2017 Category: Genetics & Stem Cells Authors: X. Liao, H. Li, W. Jiao, C. Zhu, W. Wang, Z. Mo, Z. Yang, Z. Zhu Tags: ORIGINAL ARTICLE Source Type: research